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Mayo Clinic completes first genome-wide analysis of peripheral T-cell lymphomas
Date:8/1/2012

ave a relatively poor understanding of how peripheral T-cell lymphomas develop and proliferate.

"The most common type of T-cell lymphoma is called 'not otherwise specified.' It's basically a wastebasket diagnosis because we don't understand enough about the specific genetic abnormalities to be able to pinpoint subtypes of T-cell lymphomas that might trigger different treatments by the treating oncologist," says Dr. Feldman.

Dr. Feldman's study will be used to improve diagnostic tests and develop targeted treatments for peripheral T-cell lymphoma.

Among the key findings in the genomic abnormalities of peripheral T-cell lymphoma are:

  • Thirteen recurrent chromosomal rearrangements
  • Five of the 13 rearrangements involve p53-related genes, important for tumor-suppressor function
  • Novel rearrangements involving the TP53 homologue and TP63, which were associated with shortened survival times
  • Four interchromosomal abnormalities, including the previously known ALK and DUSP22-IRF4 translocations

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    Contact: Sam Smith
    newsbureau@mayo.edu
    507-284-5005
    Mayo Clinic
    Source:Eurekalert

    Page: 1 2

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