Navigation Links
Mayo Clinic completes first genome-wide analysis of peripheral T-cell lymphomas
Date:8/1/2012

ROCHESTER, Minn.-- Researchers at Mayo Clinic have completed the world's first genome-wide sequencing analysis of peripheral T-cell lymphomas, unlocking the genetic secrets of this poorly understood and highly aggressive cancer of the immune system.

Andrew Feldman, M.D., a Mayo Clinic pathologist and Damon Runyon Clinical Investigator, and a team of researchers affiliated with Mayo's Center for Individualized Medicine and Mayo Clinic Cancer Center, found 13 genomic abnormalities that were seen in multiple peripheral T-cell lymphomas. Of particular interest, five of these abnormalities relate to production and behavior of the p53 protein -- often called the "guardian of the genome" because of the central role it plays in regulating cell life cycles and, therefore, suppressing cancers.

The study, entitled "Genome-wide Analysis Reveals Recurrent Structural Abnormalities of TP63 and other p53-related Genes in Peripheral T-cell Lymphomas," is scheduled for early release in the online edition of the journal Blood at 9 a.m. on Wednesday, Aug. 1, 2012.

"Every time I diagnose a peripheral T-cell lymphoma, I know that two out of three patients will succumb to that lymphoma," says Dr. Feldman. "That's a very unsatisfying feeling, and I hope that our research can help change those statistics."

Peripheral T-cell lymphomas account for about 12 percent of non-Hodgkin's lymphomas and carry remarkably high mortality rates. Fewer than 35 percent of patients live five years beyond diagnosis.

New diagnostic biomarkers (chemical or genetic clues in the body's system) and treatments aimed at specific subgroups of peripheral T-cell lymphomas could lead to improved outcomes, says Dr. Feldman. Developing these, however, has been a challenge for several reasons. Lymphomas that look remarkably similar under a microscope may differ substantially in their overall prognoses and responses to treatment. Additionally, scientists and doctors have a relatively poor understanding of how peripheral T-cell lymphomas develop and proliferate.

"The most common type of T-cell lymphoma is called 'not otherwise specified.' It's basically a wastebasket diagnosis because we don't understand enough about the specific genetic abnormalities to be able to pinpoint subtypes of T-cell lymphomas that might trigger different treatments by the treating oncologist," says Dr. Feldman.

Dr. Feldman's study will be used to improve diagnostic tests and develop targeted treatments for peripheral T-cell lymphoma.

Among the key findings in the genomic abnormalities of peripheral T-cell lymphoma are:

  • Thirteen recurrent chromosomal rearrangements
  • Five of the 13 rearrangements involve p53-related genes, important for tumor-suppressor function
  • Novel rearrangements involving the TP53 homologue and TP63, which were associated with shortened survival times
  • Four interchromosomal abnormalities, including the previously known ALK and DUSP22-IRF4 translocations

  • '/>"/>

    Contact: Sam Smith
    newsbureau@mayo.edu
    507-284-5005
    Mayo Clinic
    Source:Eurekalert

    Related medicine news :

    1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
    2. First targeted nanomedicine to enter human clinical studies
    3. Clinical insight improves treatment with new lung cancer drug
    4. Clinical news alert from the American Academy of Orthopaedic Surgeons
    5. Mayo Clinic launches whole genome breast cancer study
    6. Mayo Clinic offers newly approved treatment for acid reflux disease
    7. NYU Langone experts present research, clinical advances at neurosurgeons meeting
    8. Mayo Clinic breast cancer study finds new type of mutation
    9. Kroenke honored for outstanding contributions in clinical research training
    10. Awards celebrate clinical research that can improve health and alleviate suffering
    11. Association for Psychological Science, SAGE launch Clinical Psychological Science
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:8/22/2017)... ... August 22, 2017 , ... “Without Love’s Beauty ... neglect, and the struggles faced while hoping for a better life. “Without Love’s ... Judy Von Bernewitz, who spent 13 years working with deprived/neglected adolescents and almost ...
    (Date:8/22/2017)... , ... August 22, 2017 , ... “Glimpses Of Light”: ... of the world. “Glimpses Of Light” is the creation of published author, J.M. Shepherd, ... in search of answers to life’s perplexing mysteries. , Shepherd shares, “Love is one ...
    (Date:8/22/2017)... ... ... TopConsumerReviews.com recently gave a best-in-class 5-star rating to Energy NADH, a leader ... modern life continually makes more demands on time and energy, people are finding it ... in vicious high/low cycles and can also cause long term health issues. More people ...
    (Date:8/22/2017)... , ... August 22, 2017 , ... Although Labor Day ... July, many communities have begun providing weekend displays, and numerous households celebrate the unofficial ... they can be downright terrifying for pets. , Kris Zambo, owner of ...
    (Date:8/21/2017)... ... August 22, 2017 , ... Nanoparticle research provides an exciting ... By learning and implementing best practices for containment using ventilated safety enclosures, many ... gain a better understanding of a method for safely testing nanotechnology hoods. They ...
    Breaking Medicine News(10 mins):
    (Date:8/14/2017)... TIKVAH, Israel , Aug. 15, 2017 ... developer of adult stem cell technologies for neurodegenerative diseases, ... 30, 2017. "We ... pivotal Phase 3 trial to investigate NurOwn ® ... Chief Executive Officer of BrainStorm. "We have agreements with ...
    (Date:8/10/2017)...  Physical Rehabilitation Network (PRN), acquired the long-standing outpatient rehabilitation ... . The reputable clinic will continue to be co-owned ... his staff of four clinicians. Lipkin received his doctorate in ... 10 years of experience with a strong background in manual ... the 10th PRN clinic in and around the Denver ...
    (Date:8/8/2017)... Second-quarter 2017 revenues of $876 million ... continuing operations Second-quarter 2017 ... million Second-quarter 2017 Sterile ... Second-quarter 2017 adjusted diluted earnings ... to $0.93 Second-quarter 2017 ...
    Breaking Medicine Technology: