Mayo Clinic breast cancer study finds new type o... ( JACKSONVILLE Fla. Their study p...)

Mayo Clinic breast cancer study finds new type of mutation

Date:4/15/2012

JACKSONVILLE, Fla. Mayo Clinic researchers have discovered a new class of molecular mutation in various forms of breast cancer, a finding that may shed new light on development and growth of different types of breast tumors. Called fusion transcripts, the mutated forms of RNA may also provide a way to identify tumor subtypes and offer new strategies to treat them, investigators say.

Their study, published in the April 15 issue of Cancer Research, is the first to systematically search for fusion genes and fusion transcripts linked to different types of breast tumors.

Oncologists currently recognize three basic types of breast tumors estrogen-receptor (ER)-positive, HER2-positive, and triple negative.

"But breast cancer is much more complex than indicated by these three subtypes, and one of the challenges of treating the disease is to identify gene markers that predict how a tumor will respond to a specific treatment," says senior investigator Edith Perez, M.D., deputy director of the Mayo Clinic Comprehensive Cancer Center in Florida and director of the Breast Cancer Translational Genomics Program, which involves researchers at all three Mayo Clinic campuses.

"The discovery of subtype-specific fusion transcripts in breast cancer represents a step in this direction," she says. "Our findings indicate that fusion transcripts are much more common in breast cancer than had been realized. They represent a new class of mutation whose role in breast cancer is not understood at all."

"Fusion transcripts have the power to produce proteins that are relevant to tumor development, growth, and sensitivity to treatment, so we may have a brand new set of genomic changes that may help us understand, and
'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

0

GOOD

Page: 1 2 3
Related medicine news :

1. NYU Langone experts present research, clinical advances at neurosurgeons meeting
2. Mayo Clinic offers newly approved treatment for acid reflux disease
3. Mayo Clinic launches whole genome breast cancer study
4. Clinical news alert from the American Academy of Orthopaedic Surgeons
5. Clinical insight improves treatment with new lung cancer drug
6. First targeted nanomedicine to enter human clinical studies
7. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
8. Early clinical data show galeterone safe, effective against prostate cancer
9. Cleveland Clinic study shows bariatric surgery improves, reverses diabetes
10. Stephanie R. Wilson, MD, to be presented with the Joseph H. Holmes Clinical Pioneer Award
11. Mayo Clinic researchers building melanoma vaccine to combat skin cancer

Post Your Comments:

(Date:5/22/2013)... (PRWEB) May 22, 2013 Hosted by ... Cares free dental clinic provided more than $1.6 million ... May 18-19 in San Jose. , The California ... the clinic to provide free dental services and oral ... This is the third clinic held by CDA and ...

(Date:5/22/2013)... Reporter , , WEDNESDAY, May 22 (HealthDay News) -- Anyone ... is something about feet that fungi seem to like. ... the fungal groups that live on your skin -- ... It,s no secret that the human body is ... fungi, both outside and inside. And it,s mainly a ...

(Date:5/22/2013)... 2013 Successful Therapy for Parents ... Psychotherapy in the Silver Lake community of Los ... as progression to existing Parents and Couples counseling ... parenting therapy has always been suggested, but now ... now specializes in all aspects of relationships ...

(Date:5/22/2013)... 22, 2013 According to a May 14, ... More Options for Breast Cancer Surgery,” modern medical technology has ... approach this disease in a whole new light. Since the ... now face breast cancer and mastectomies with greater ... “Before the introduction of plastic surgery to oncology, women had ...

(Date:5/22/2013)... Researchers in genomic health disparities from the University of ... School of Medicine have teamed up to hold the ... Health Disparities in Genomic Medicine." The theme of ... business and government to reduce these disparities. , Despite ... States, individuals within underserved groups continue to be more ...

Breaking Medicine News(10 mins):Health News:Two-day San Jose Dental Clinic Provides More Than $1.6 Million in Care 2 Health News:Scientists Map the Fungi on Your Feet 2 Health News:Scientists Map the Fungi on Your Feet 3 Health News:Patricia O’Laughlin Psychotherapy of Los Angeles Now Seeing Adults, Teens and Young Children 2 Health News:Breast Augmentation – New Option for Breast Cancer Surgeries 2 Health News:Why We Can't Wait: Conference to Eliminate Health Disparities in Genomic Medicine 2

[0] Two-day San Jose Dental Clinic Provides More Than $1.6 Million in Care [0] Scientists Map the Fungi on Your Feet [0] Patricia O’Laughlin Psychotherapy of Los Angeles Now Seeing Adults, Teens and Young Children [0] Breast Augmentation – New Option for Breast Cancer Surgeries [0] Why We Can't Wait: Conference to Eliminate Health Disparities in Genomic Medicine

... health system of southern Australian hospitals has been graded at ... surgery admissions //and waiting times. ,This rating has ... recorded the second highest number of beds per capita in ... for every 1000 in population. ,Health Minister Tony ...

... New South Wales in Australia have developed a "super ... diabetes//, heart disease, arthritis and cancer. The drug, Dz13, ... aging as well, the researchers claimed. ,Also diseases like ... in a paper published in the latest issue of ...

... Pharma today said it has recieved a tentative New ... product used for treating HIV-1 infection//. ... drug product containing Lamivudine, Zidovudine, Nevirapine tablets used in ... Bombay Stock Exchange., ,The three drugs would now ...

... have discovered a method to cease the blood supply to ... cancer//. This, if proved conclusively, will infuse a new lease ... a protein, discovered while conducting a research on fruits, is ... them naturally. , ,The researchers said “By blocking the ...

... members and villagers, a woman who lost her husband to AIDS ... Bihar home. ,Premila Devi, 40, from Tilaei village in ... just a few months after her husband Sunil Mahto died of ... members as well as villagers treated her after her husband's death," ...

... determination test kits to counter online threats to its skewed ... Home DNA gender testing kit' for $275 promising results within ... unborn girls in Punjab, Haryana and Delhi. ,"We ... Health Minister Ramesh Chander Dogra told a news channel Sunday. ...

Cached Medicine News:Health News:South Australian health System In The Bottom Of Rankings 2

South Australian health System In The Bottom Of Rankings "Super Drug" Targets Disease-Causing Gene Aurobindo Gets Tentative USFDA Approval For Its HIV-1 Drug Cessation of blood supply to cancer cells may curtail spread, novel research Ostracized AIDS Patient Commits Suicide in Bihar Punjab Plans of Banning Sex Determination Kit from US

(Date:5/22/2013)... 2013 Grifols, ein globales Unternehmen der ... , Spanien, präsentierte die Ergebnisse einer ... von PROLASTIN©-C (Alpha1-Proteinasehemmer [human]) den Spiegel des ... ein Niveau anhebt, das innerhalb des für ... ist eine lebensbedrohliche, genetische Erkrankung, bei der ...

(Date:5/22/2013)... Israel , May 22, 2013 /PRNewswire/ ... leading developer and provider of microRNA-based molecular diagnostics, announces ... and Chief Executive Officer of Rosetta Genomics, will deliver ... taking place from June 3-6, 2013 in New York ... June 4 th at 2:00 p.m. Eastern time. ...

(Date:5/22/2013)... , May 22, 2013 Medifocus, Inc. (OTCQX: MDFZF and ... , Chief Operating Officer, will present at the Second Annual ... New York City at the Grand ... to begin at 4:00 p.m. EDT and will be available ... http://wsw.com/webcast/marcum/mfs.v/ For more information and registration, ...

Breaking Medicine Technology:Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 2 Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 3 Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 4 Rosetta Genomics to Present at the Jefferies 2013 Healthcare Conference 2 Rosetta Genomics to Present at the Jefferies 2013 Healthcare Conference 3 Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 2 Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 3

[0] Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt [0] Rosetta Genomics to Present at the Jefferies 2013 Healthcare Conference [0] Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference

... June 21 Lexicon Pharmaceuticals, Inc. (Nasdaq: ... treatments for human disease, presented clinical data and analysis from ... patients with type 2 diabetes mellitus at ENDO 2010 today. ... of increased total GLP-1 in both LX4211 treatment arms relative ...

... 21 Reportlinker.com announces that a new market research report is available ... Global Coronary ... , , ... , , ...

Lexicon Presents Data Describing LX4211 Positive Phase 2 Clinical Results and Novel Mechanism of Action for Type 2 Diabetes Reportlinker Adds Global Coronary Stents Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016

... Quality EEG recording is assured even ... Neurofax has high performance, high sensitivity ... ECG rejection filter, shielded electrodes and a ... connection. Neurofax is a complete and ...

... MagPro is the high performance magnetic stimulator ... in medical research. , ,MagPro is able to ... precise studies of the field/nerve interface can be ... biphasic waveform and coil-current direction. , , , ...

... is a new top-line range of digital ... Atrial Fibrillation (AF). Because the T-series combines ... the treatment of AF is taken one ... the heart rhythm is monitored continuously and ...

... MAX Cooling Power, Deeper Lesions ... arrhythmias, including atrial flutter, Freezor MAX is ... catheter with an 8mm ablation tip was ... is connected to the same cryoconsole as ...

Medicine Products:

Neurofax EEG-9100 MagPro T-series (T70 DR, T60 DR, T20 SR )Freezor MAX