Navigation Links
Mayo Clinic and Illinois researchers develop new sensor for methylated DNA
Date:3/14/2013

ROCHESTER, Minn. -- Collaborators from Mayo-Illinois Alliance for Technology Based Healthcare have developed a new, single molecule test for detecting methylated DNA. Methylation -- the addition of a methyl group of molecules to a DNA strand -- is one of the ways gene expression is regulated. The findings appear in the current issue of Scientific Reports (Nature Publishing Group).

"While nanopores have been studied for genomic sequencing and screening analysis, this new assay can potentially circumvent the need for some of the current processes in evaluating epigenetics-related diseases," says George Vasmatzis, Ph.D., co-leader of Mayo's Biomarker Discovery Program in the Center for Individualized Medicine and co-lead author on the article. He says the assay could eliminate the need for bisulfite conversion of DNA, fluorescent labeling, and polymerase chain reaction (PCR).

"Next steps include increasing the spatial resolution by incorporating thinner membranes and by integrating the same preparation steps," says Rashid Bashir, Ph.D., professor of bioengineering, director of the Micro and Nanotechnology Laboratory, and co-lead author of the study at the University of Illinois at Urbana-Champaign.

A nanopore, in this case, is a very small hole in an artificial membrane, that allows only a single molecule to be located and identified. Researchers say this is useful as methylation in promoter sequences can indicate tumor development in most major types of cancer and may be a better biomarker than many genetic markers. Scientists are now able to differentiate methylated from non-methylated DNA by attaching a protein on the methylated nucleotides measuring ionic electrical current via a solid-state nanopore.


'/>"/>
Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. TherapySites (Websites for Therapists) Announces Partnership with California Society for Clinical Social Work to Offer Website Marketing for Social Workers
2. Online Health Coach Training Announced by Leading Clinical Health Coach Organization
3. AMD Global Telemedicine Increases Data Sharing Capabilities for Clinicians and Physicians with AGNES 3.1.0
4. Womens College Hospital clinician-scientist to receive prestigious YWCA award
5. Paul Larson OB/GYN Clinic Earns Top Rankings in a Recent Quality Report
6. Combination therapy provides similar clinical benefit as single drug treatment in MS
7. Mayo Clinic study finds electric car does not interfere with implanted cardiac devices
8. Calm Clinic Reports: Anxiety Information Seeking at All Time High
9. Patients with post-ACS depression benefitted from active treatment in clinical trial
10. Thomas Eye Group Continues Growth in Metro Atlanta Area With Two Clinic Expansions
11. Money talks when it comes to losing weight, Mayo Clinic study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... October 20, 2014 ASCNYC (ascnyc.org) ... that helps New Yorkers living with HIV/AIDS and ... health, housing, recovery and self-sufficiency. Each year, ASCNYC ... local community through their tireless efforts. , ... Shapses , has been selected as this year’s ...
(Date:10/20/2014)... 20, 2014 JZ Fitness, an independently ... corporate wellness programming, authorship, international lecturing and community wellness, ... announce the release of the JZ Fitness nutrition app, ... of coaching thousands of individuals on nutrition, Jenn Zerling ... does not require calorie counting or cumbersome food logging. ...
(Date:10/20/2014)... 2014 Rockynol Retirement Community ... Oct. 14. The $11 million project will include the ... cooked-to-order kitchen with full-service restaurant style dining. , “We ... first class Assisted Living apartments,” said Kara Hanzie, Rockynol ... highest quality of care and this investment is proof ...
(Date:10/20/2014)... Unveiled at the Sept. 18 board meeting, ... estimates member hospital ROI on membership dues at 12.5. In ... provides $12.50 in value to member hospitals. The calculation used ... Dues)/Member Dues. , “This is the first time we’ve ... think the methodology is really sound,” said Bill Ryan ...
(Date:10/19/2014)... 20, 2014 Hastings and Hastings, a ... of service throughout the greater Phoenix area and across ... with regard to catastrophic automobile accidents. Statistics have indicated ... and throughout Arizona. As such, Hastings and Hastings has ... representation for those who have been injured through no ...
Breaking Medicine News(10 mins):Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3
... celebrating his one Year Anniversary as a Non-Smoker 60 Pounds Lighter. What ... quit smoking or lose 60 pounds but to do both within one year ... was able to turn his life around and improve his quality of life; ... , ...
... voice preference on two California reorganization plans , ... members began casting ballots this week in an advisory vote ... register their preferences on whether they want to be part ... a new statewide local representing a broader classification of healthcare ...
... County Health Director, Dr. Bob England Encourage all Families to ... One Middle School , , ... that Arizona has its first lab-confirmed case of influenza in ... Public Health, the Arizona Department of Health Services, the Arizona ...
... announced today the Company will hold an,investor conference call to discuss current business conditions ... is,(866) 901-2585. The international call in number is (404) 835-7099. , , ... & ... ctrego@minrad.com , ...
... Consulting Inc.,announces the addition of two new areas of ... engineering and technology,services. The company is also launching its ... The company has realigned its services into ... sustainability. , "We ...
... useful, studies find , , WEDNESDAY, Nov. 19 (HealthDay News) -- ... diabetes was no better at predicting a person,s risk for ... , The news is both encouraging and discouraging. , "The ... risk," said Dr. James Meigs, lead author of one of ...
Cached Medicine News:Health News:Former Smoker Celebrates One Year Anniversary of Being a Non-Smoker 60 Pounds Lighter 2Health News:Former Smoker Celebrates One Year Anniversary of Being a Non-Smoker 60 Pounds Lighter 3Health News:Advisory Vote Begins on California Long-Term Care Local 2Health News:American Lung Association of Arizona, Phoenix Fire and Maricopa County Public Health Urge Residents to Get Vaccinated Against the Flu 2Health News:American Lung Association of Arizona, Phoenix Fire and Maricopa County Public Health Urge Residents to Get Vaccinated Against the Flu 3Health News:American Lung Association of Arizona, Phoenix Fire and Maricopa County Public Health Urge Residents to Get Vaccinated Against the Flu 4Health News:Environmental and Technology Firm Integral Consulting Inc. Expands Services, Launches New Website 2Health News:Genetic Testing No Real Help in Predicting Type 2 Diabetes 2Health News:Genetic Testing No Real Help in Predicting Type 2 Diabetes 3
(Date:10/20/2014)...  AnaptysBio, Inc., a leader in the discovery ... appointment of Marco Londei , M.D. as ... preclinical and clinical development of AnaptysBio,s proprietary antibody ... welcome Dr. Londei to AnaptysBio,s executive leadership team," ... Executive Officer of AnaptysBio. "Dr. Londei,s extensive expertise ...
(Date:10/20/2014)... 20, 2014 Pharmaceutic Labs announces the opening ... Albany, NY for admixing, compounding, drug ... and/or exceeds the FDA standards for safety and quality, ... 211. The 10,000 square foot outsourcing ... quality assurance and quality control. The company will produce ...
(Date:10/20/2014)... and RALEIGH, N.C., Oct. 20, 2014 /PRNewswire/ ... Neuropathy Foundation (HNF), both philanthropies, announced today the ... candidates for the treatment of the rare disease ... BioPontis Alliance announced its alliance model earlier this ... first demonstration of a collaborative model where researchers ...
Breaking Medicine Technology:AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2The Hereditary Neuropathy Foundation and BioPontis Alliance for Rare Disease Partner to Develop Treatments for Charcot-Marie-Tooth 2The Hereditary Neuropathy Foundation and BioPontis Alliance for Rare Disease Partner to Develop Treatments for Charcot-Marie-Tooth 3
Cytomegalovirus IgG ELISA....
Cytomegalovirus IgM ELISA....
Blunt tipped forceps with tungsten carbide treated jaws for enhanced gripping and removal of large sized foreign bodies....
Microforceps: Diamond Dusted Micro Pic Forceps...
Medicine Products: