Navigation Links
Mayo Clinic: Scheduled imaging studies provide little help detecting relapse of aggressive lymphoma

ROCHESTER, Minn. -- Imaging scans following treatment for diffuse large B-cell lymphoma do little to help detect a relapse, a Mayo Clinic study has found. The overwhelming majority of patients with this aggressive lymphoma already have symptoms, an abnormal physical exam or an abnormal blood test at the time of relapse, the researchers say. The findings will be presented at the American Society of Clinical Oncology annual meeting May 31-June 4 in Chicago.

"Our results were surprising because the current standard-of-care is to include scans for the follow-up of this disease," says lead author Carrie Thompson, M.D., a Mayo Clinic hematologist. "We found that scans detected relapse in only a handful of patients who didn't have any of those other signs or symptoms. I think our study suggests that we are getting closer to understanding how to optimize follow-up in this patient population."

Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma, with nearly 20,000 new cases diagnosed in the United States each year. The aggressive lymphoma can be cured if treated in its early stages. The cancer will come back in 20 to 30 percent of cases, and the best strategy for catching that relapse is unclear. In this study, Dr. Thompson and her colleagues looked at patients in remission to identify how relapses were detected.

Researchers followed 537 patients treated with anthracycline-based immunochemotherapy and enrolled in the Mayo Clinic/University of Iowa Special Program of Research Excellence (SPORE) Molecular Epidemiology Resource. Of the 109 patients who relapsed, 62 percent went to the doctor earlier than a planned follow-up visit due to the re-emergence of symptoms such as enlarged lymph nodes, fever, night sweats, pain or weight loss. At the time of relapse, 68 percent had symptoms, 42 percent had an abnormal physical exam, and 55 percent had an abnormal blood test. Performing surveillance scans detected relapse in only eight patients whose symptoms had not yet started to reappear.

Dr. Thompson is now interested in surveying physicians and patients to assess their attitudes and beliefs surrounding the use of scans during remission. Her previous work suggested that patients experience a significant amount of anxiety waiting for a follow-up scan.

"Sometimes scans can provide reassurance, but, at the same time, the anticipation of a scan can provoke quite a bit of anxiety," Dr. Thompson says. "And we know from this data that scans detected relapses only in a minority of patients. So we need to think about how we can individualize care to particular patients, keeping in mind their disease, their experience and their fears. Further studies are necessary to determine the optimal follow-up strategy."


Contact: Joe Dangor
Mayo Clinic

Related medicine news :

1. Mayo Clinic: New multiple myeloma treatment guidelines personalize therapy for patients
2. Mayo Clinic: Skin problems, joint disorders top list of reasons people visit doctors
3. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
4. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
5. Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
6. Mayo Clinic: Diabetes can be controlled in patients after pancreas removal
7. Mayo Clinic: Drug duo turns on cancer-fighting gene in kidney, breast cancers
8. Mayo Clinic: Common blood pressure drug linked to severe GI problems
9. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
10. Mayo Clinic: Standard heart disease risk tools underrate danger in rheumatoid arthritis
11. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... Califia Farms , one ... its iconic bottle has won top honors in Beverage World Magazine’s Global Packaging Design ... announced that it has been selected as a 2015 U.S.A. Taste Champion in the ...
(Date:12/1/2015)... ... December 01, 2015 , ... December 1, 2015—Since the start ... scientific research and discoveries, leading us to better understand the disease’s behavior. Globally, ... affected by HIV/AIDS. Mediaplanet’s cross-platform edition of “World AIDS Day” provides insight on ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... optimization of adjunctive imaging is the focus of numerous abstracts accepted for presentation ... 29-December 4, 2015. Nine abstracts highlight the use of Volpara Solutions’ quantitative ...
(Date:12/1/2015)... WA (PRWEB) , ... December 01, 2015 , ... ... today that it has been selected as a finalist in this year’s Fierce ... and FierceMobileHealthcare. Next IT Healthcare was recognized as a finalist in the category ...
(Date:12/1/2015)... ... December 01, 2015 , ... XTC Semifinals 2016 - ... to head to Las Vegas for CES 2016, the world’s largest Consumer Electronic Show, ... Technology Association Gary Shapiro, Founding Partner of Pacific Investments Veronica Serra, and venture capitalist ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... BANGALORE, India and PITTSBURGH ... TASE: MYL) today announced that it expects to be ... developing country markets funded by international donors, TLE400 (Tenofovir ... Efavirenz 400 mg) for $99 per patient, per year. ... to develop TLE400. The significantly reduced price could generate ...
(Date:12/1/2015)... , Dec. 1, 2015 Breg, Inc ... services, announced today that it has been awarded three ... Members served by Novation will have access to improved ... bracing products and soft goods dedicated to advancing orthopedic ... The aging U.S. population, rising prevalence of chronic ...
(Date:12/1/2015)... N.J. , Dec. 1, 2015 ... against HIV/AIDS, Johnson & Johnson (NYSE: JNJ ... its Janssen Pharmaceutical Companies to significantly reduce the ... who make up 74 percent of new HIV ... Announced on World AIDS Day, these new initiatives ...
Breaking Medicine Technology: