Navigation Links
Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
Date:6/20/2012

JACKSONVILLE, Fla. A molecule widely believed to fight many forms of cancer actually helps deadly thyroid tumors grow, and cancer therapies now being tested in humans might boost the activity of this newly revealed bad guy, researchers at Mayo Clinic in Florida say. Their findings are published online this month in the Journal of Cell Science.

The study found that in anaplastic thyroid cancer, the Forkhead transcription factor, FOXO3a, is not the helpful tumor suppressor everyone thought it was, but, instead, is a lethal promoter of tumor growth. When FOXO3a was silenced in laboratory models of human anaplastic thyroid cancer, the cells grew slowly, but when it was added, they grew much faster.

"This result is exactly the opposite of what we expected," says senior author John A. Copland, Ph.D., a Mayo cancer biologist. "We were more than surprised. We were concerned."

FOXO3a is known as a suppressor of tumor growth because it responds to all forms of cell stress, including that produced in cancer, by turning on genes inside the nucleus that trigger the cell's death. Cancer, in turn, is known to shut down FOXO3a by sending it out of the nucleus and into the cell's cytoplasm, where it is degraded. The molecule that ships FOXO3a out of the nucleus is Akt, which tries to keep cancer cells alive.

The research team used an Akt blocker similar to the ones now being used in human cancer clinical trials expecting to increase nuclear FOXO3a and suppress cancer growth in anaplastic thyroid cancer. They were trying to find a treatment for one of the deadliest known
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mayo Clinic: Obesity epidemic fueling rise in rheumatoid arthritis among women
2. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
3. Mayo Clinic: Standard heart disease risk tools underrate danger in rheumatoid arthritis
4. Molecule movements that make us think
5. Prions in the brain eliminated by homing molecules
6. Researchers identify a life-and-death molecule on chronic leukemia cells
7. Inhibitors of shuttle molecule show promise in acute leukemia
8. Killing in war linked with suicidal thoughts among Vietnam veterans, study finds
9. Wartime Killing May Raise Veterans Thoughts of Suicide
10. Multiple thought channels may help brain avoid traffic jams
11. Sleepwalking in Adults More Common Than Thought
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... It’s a pattern that won’t relent anytime ... on this planet, cyber scammers will immediately be thinking ... their own personal gain. And on April 30, ... issued an alert titled “Nepal Earthquake Disaster Email Scams,” ... earthquake in Nepal. The scam emails may contain links ...
(Date:5/2/2015)... “ Peachtree Audio ” was featured on NewsWatch ... the latest and coolest technology products available to consumers. ... NewsWatch, conducted the review and shared with viewers how ... is an important part of people’s lives – and ... royal treatment. Peachtree Audio does just that with high-end ...
(Date:5/2/2015)... 2015 Kare Visits LLC. launched in Chicago ... caregivers. Kare Visits offers relief for caregivers by visiting ... According to the Caregiver Action Network, eight in ... 20 hours a week caring for an elderly or disabled ... hire a nurse, a caregiver is now empowered to schedule ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 ZoomCare, the ... has submitted plans to offer its new healthcare insurance ... The ZOOM+ Personal Health Insurance System is the nation’s ... to enhance human performance. ZOOM+ Personal Health Insurance was ... delivery system that are subject to review and regulation ...
(Date:5/1/2015)... 2015 IDLife LLC, a health and ... announce the addition of its newest partner and fitness ... long athlete, growing up in gymnastics and competitive diving, ... becoming a personal trainer and helping others achieve their ... several TV shows highlighting her stunning physique and unique ...
Breaking Medicine News(10 mins):Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:ZoomCare Applies to be on Oregon Exchange 2Health News:IDLife LLC Announces New Partnership with Fitness Celebrity, Jen Widerstrom 2
... NEW YORK, Jan. 7 Crystal Research Associates, ... Informational Overview(R),(EIO(R)) on Unilife Medical Solutions Limited (UNI-ASX). ... www.crystalra.com and www.unilife.com . , ... or "the Company") develops,and supplies innovative safety medical ...
... can be healthy and hazardous for seniors, experts ... head south each winter to escape the cold often feel ... are adjustments to be made to make sure these "snowbirds" ... more time socializing, boosts mood and well being for 65-plus ...
... Jan. 7 AGA Medical Corporation ("AGA,Medical") announced ... Ministry,of Health, Labour and Welfare (MHLW) for its ... transcatheter occlusion device used for the,non-surgical closure of ... heart defect that occurs when a blood vessel ...
... Jan. 7 Pearson VUE, the computer-based testing ... signed an agreement with the National Association of ... test delivery provider of the computer-based Foreign Pharmacy ... these exams will be delivered throughout the secure ...
... FL, Jan. 7 /PRNewswire-FirstCall/ - Hard to Treat Diseases ... announce that it has identified a cosmetics company as ... in E Europe (Serbia) is engaged in online sales ... skin and lip balm. It has a wide variety ...
... REDWOOD CITY, Calif., Jan. 7 Ingenuity Systems, ... researchers, today,announced the release of IPA 7 with ... of a series of powerful biological filters and ... experimental results and fine-,tune scientific hypotheses in relation ...
Cached Medicine News:Health News:Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Unilife Medical Solutions Limited 2Health News:Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Unilife Medical Solutions Limited 3Health News:'Snowbirds' Beware the Climate Changes 2Health News:'Snowbirds' Beware the Climate Changes 3Health News:AGA Medical Receives Japanese Approval for AMPLATZER(R) Duct Occluder 2Health News:AGA Medical Receives Japanese Approval for AMPLATZER(R) Duct Occluder 3Health News:NABP Expanding Computer-Based Test Delivery to Include Foreign Pharmacy Graduate Equivalency Examination(R) 2Health News:Hard To Treat Diseases (HTDS) Set To Acquire Cosmetics Company 2Health News:IPA 7 Introduces Unique Contextual Search and Analysis Capabilities 2
(Date:5/1/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vzcw2v/americas_clinical ) has ... Market by Product, by End-Users - Forecast to 2019" ... Analyzers market is estimated to grow at a CAGR of ... Canada , Mexico , ... are covered in this report. The Americas is ...
(Date:5/1/2015)... -- Portal Instruments, Inc., an emerging leader in the development ... Robert Langer, Sc. D., MIT Institute Professor, and ... have joined the company,s Scientific Advisory Board. ... Professor Robert Langer and Professor Peter ... Anquetil , Chief Executive Officer of Portal Instruments. "We ...
(Date:5/1/2015)... May 1, 2015  CytRx Corporation (CYTR), a ... today reported financial results for the three months ... of recent accomplishments and upcoming milestones for its ... milestones in the early months of 2015, including ... trial of aldoxorubicin in patients with soft tissue ...
Breaking Medicine Technology:Americas Clinical Chemistry Analyzer (Semi-Automated Clinical Chemistry and Fully-Automated Clinical Chemistry) Market - Forecast to 2019 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 3Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 4CytRx Reports First Quarter 2015 Financial Results 2CytRx Reports First Quarter 2015 Financial Results 3CytRx Reports First Quarter 2015 Financial Results 4CytRx Reports First Quarter 2015 Financial Results 5CytRx Reports First Quarter 2015 Financial Results 6CytRx Reports First Quarter 2015 Financial Results 7CytRx Reports First Quarter 2015 Financial Results 8CytRx Reports First Quarter 2015 Financial Results 9CytRx Reports First Quarter 2015 Financial Results 10CytRx Reports First Quarter 2015 Financial Results 11
... 17, 2012  PLC Systems Inc. (OTC: PLCSF), a company ... an article summarizing the results from its U.S. pilot ... December 26, 2011 International Journal of Cardiology , ... Adult Congenital Heart Disease. The results from this ...
...  Palatin Technologies, Inc. (NYSE Amex: PTN ) ... $1.1 million of non-dilutive funding through the New Jersey ... sold both New Jersey net operating losses and research ... Last year, Palatin Technologies received approximately $637,000 under this ...
Cached Medicine Technology:Results From Pilot Trial of PLC's RenalGuard® Published in International Journal of Cardiology 2Results From Pilot Trial of PLC's RenalGuard® Published in International Journal of Cardiology 3
... Card, three HRR symbol cards and instructions. Kit ... subsequent HRR 4th Edition color testing. There are ... youngest patients, the parents can borrow the kit ... matching and become familiar with the HRR symbols. ...
Magnetic Farnsworth D15 kit. Magnets move the color disks. Protects disks from fingerprints. Keeps all the disks in one place. Clear glass insures accurate color perception. Makes color testing fun....
... pseudoisochromatic test from Richmond Products includes the four ... 14 diagnostic series for a total of 24 ... tab for easy and clean page selection. The ... English and a laminated copy of the score ...
Ishihara 14 plate color vision testing set. Suitable for screening purposes....
Medicine Products: