Navigation Links
Mayo Clinic: How gold nanoparticles can help fight ovarian cancer
Date:5/21/2013

ROCHESTER, Minn. Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow manage to avoid nanoparticle toxicity. Mayo Clinic researchers found out why, and determined how to make the nanoparticles effective against ovarian cancer cells. The discovery is detailed in the current online issue of the Journal of Biological Chemistry.

"This study identifies a novel mechanism that protects ovarian cancer cells by preventing the cell death or apoptosis which should occur when they encounter positively charged nanoparticles," say the senior authors of this study, Priyabrata Mukherjee, Ph.D., a Mayo Clinic molecular biologist, and Y.S. Prakash, M.D., Ph.D., a Mayo Clinic anesthesiologist and physiologist.

Why Cancer Cells Survived

Gold nanoparticles can have many medical uses, from imaging and aiding diagnoses to delivering therapies. In this case, using a special preparation to put positive ionic charges on the surface, the nanoparticle is intended to act as a targeted destructor of tumor cells while leaving healthy cells alone. The nanoparticles are supposed to kill cells by causing cellular calcium ion levels to increase. But researchers discovered that a regulatory protein in the mitochondria essentially buffers the rising calcium by transporting it into the mitochondria, thus subverting cell death. Cancer cells have an abundance of this transporter and may thus be protected from nanoparticle toxicity.

The research team discovered that if they inhibit calcium uptake into the mitochondria, sufficient cellular stress builds up, making the gold nanoparticles more effective in destroying cancer cells.

The researchers say that understanding how mitochondrial transport mechanisms work will help in the design of targeted therapies against cancer. They called for nanoparticle developers to integrate this new mechanistic knowledge into their processes for designing nanoparticle properties to be used in the
'/>"/>

Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mayo Clinic: Inflammatory bowel disease raises risk of melanoma
2. Mayo Clinic: Scheduled imaging studies provide little help detecting relapse of aggressive lymphoma
3. Mayo Clinic: New multiple myeloma treatment guidelines personalize therapy for patients
4. Mayo Clinic: Skin problems, joint disorders top list of reasons people visit doctors
5. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
6. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
7. Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
8. Mayo Clinic: Diabetes can be controlled in patients after pancreas removal
9. Mayo Clinic: Drug duo turns on cancer-fighting gene in kidney, breast cancers
10. Mayo Clinic: Common blood pressure drug linked to severe GI problems
11. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... (PRWEB) December 17, 2014 Project Veritas ... recently brought videos of MIT economist and Obamacare architect ... author James O’Keefe conducted the interview, which is being ... that there was intentional mislabeling in the Affordable Care ... the bill: A two-hundred-and-fifty billion dollar per year tax ...
(Date:12/17/2014)... Dec. 16, 2014 (HealthDay News) -- Expectant parents should ... and Drug Administration recommends. Use of ultrasound imaging ... is not entirely risk-free, the agency warns. ... harm due to ultrasound imaging and heartbeat monitors, prudent ... is important," Shahram Vaezy, an FDA biomedical engineer, said ...
(Date:12/17/2014)... Alan Mozes HealthDay ... With the holiday party season fast approaching, a new study ... make DUI arrests have fewer drunk drivers on their roads. ... laws more vigilantly are better able to deter inebriated revelers ... "Hardly any new laws are being passed regarding drinking and ...
(Date:12/15/2014)... A recent survey found that the ... impacting skin health and beauty were: “Connections,” “climate,” “career” ... Water and health advocate and radio host Sharon Kleyne ... the survey and the Four C’s.* Kleyne notes, however, ... discussed would benefit from paying attention to one’s daily ...
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), Unionville’s first ... study providing evidence on the impact of 100% pure ... Sufficient enough evidence already exists showing a negative link ... with the onset of tooth decay. One question that ... 100% fruit juice, meaning it is completely natural with ...
Breaking Medicine News(10 mins):Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 3Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2
... By Steven Reinberg HealthDay Reporter , THURSDAY, ... who undergo surgery for epilepsy remain free of seizures 10 ... to treat patients with medication, and only when drugs can,t ... patient become a candidate for surgery. This study suggests that ...
... Pediatric patients, primarily those who are underinsured (either ... psychiatric care in hospital emergency departments (EDs), according ... the American Academy of Pediatrics (AAP) National Conference ... data, including patient age, sex, race, ethnicity, insurance ...
... use the Internet to learn about pediatric health problems, ... this information, and how they use it prior to ... Usage by Parents Prior to Seeking Care at a ... American Academy of Pediatrics (AAP) National Conference and Exhibition ...
... to die from cancer It is known that the ... married counterparts and there is some indication that the divide ... Central,s open access journal BMC Public Health looks ... years and show that the difference in mortality between the ...
... Gardner HealthDay Reporter , THURSDAY, Oct. 13 (HealthDay ... a heavy toll on the body, researchers say. The ... have more heart disease, diabetes and other age-related conditions, according ... of Behavioral Medicine . This study may be ...
... , THURSDAY, Oct. 13 (HealthDay News) -- Smoky, inefficient indoor ... in developing nations contribute to 2 million deaths a year, ... stoves affects about 3 billion people, or nearly half the ... wrote in a commentary published in the current issue of ...
Cached Medicine News:Health News:For Many, Epilepsy Surgery Effective Long-Term 2Health News:For Many, Epilepsy Surgery Effective Long-Term 3Health News:Parents who go online for pediatric health information are open to doctors' website recommendations 2Health News:Could Discrimination Help Trigger Illness in Blacks? 2Health News:Globally, 2 Million Deaths a Year Linked to Smoky Stoves 2
(Date:12/15/2014)... TARRYTOWN, N.Y. and BRIDGEWATER, N.J. ... Inc. (NASDAQ: REGN) and Sanofi US (EURONEXT: SAN and ... heart disease organizations to launch Cholesterol Counts , ... know about cholesterol, their numbers, and the risks associated ... to visit www. CholesterolCounts .com to take ...
(Date:12/15/2014)... --  DaVita HealthCare Partners Inc.  (NYSE: ... most innovative health care communities, today announced that ... Research  (DCR) and  HealthCare Partners Clinical Research , will ... research and data analytics services, specifically in patients ... disease (ESRD), as well as primary care and ...
(Date:12/13/2014)... , December 12, 2014 ... has announced the addition of the  "Global ... Size, Share, Global Trends, Company Profiles, Analysis, ...  report to their offering.       ... tubes made up of medical grade material ...
Breaking Medicine Technology:Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4Global Catheters Market (Product Types and Geography) - Forecast to 2020 2Global Catheters Market (Product Types and Geography) - Forecast to 2020 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: