Navigation Links
Mayo Clinic: How gold nanoparticles can help fight ovarian cancer
Date:5/21/2013

ROCHESTER, Minn. Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow manage to avoid nanoparticle toxicity. Mayo Clinic researchers found out why, and determined how to make the nanoparticles effective against ovarian cancer cells. The discovery is detailed in the current online issue of the Journal of Biological Chemistry.

"This study identifies a novel mechanism that protects ovarian cancer cells by preventing the cell death or apoptosis which should occur when they encounter positively charged nanoparticles," say the senior authors of this study, Priyabrata Mukherjee, Ph.D., a Mayo Clinic molecular biologist, and Y.S. Prakash, M.D., Ph.D., a Mayo Clinic anesthesiologist and physiologist.

Why Cancer Cells Survived

Gold nanoparticles can have many medical uses, from imaging and aiding diagnoses to delivering therapies. In this case, using a special preparation to put positive ionic charges on the surface, the nanoparticle is intended to act as a targeted destructor of tumor cells while leaving healthy cells alone. The nanoparticles are supposed to kill cells by causing cellular calcium ion levels to increase. But researchers discovered that a regulatory protein in the mitochondria essentially buffers the rising calcium by transporting it into the mitochondria, thus subverting cell death. Cancer cells have an abundance of this transporter and may thus be protected from nanoparticle toxicity.

The research team discovered that if they inhibit calcium uptake into the mitochondria, sufficient cellular stress builds up, making the gold nanoparticles more effective in destroying cancer cells.

The researchers say that understanding how mitochondrial transport mechanisms work will help in the design of targeted therapies against cancer. They called for nanoparticle developers to integrate this new mechanistic knowledge into their processes for designing nanoparticle properties to be used in therapy.


'/>"/>

Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Mayo Clinic: Inflammatory bowel disease raises risk of melanoma
2. Mayo Clinic: Scheduled imaging studies provide little help detecting relapse of aggressive lymphoma
3. Mayo Clinic: New multiple myeloma treatment guidelines personalize therapy for patients
4. Mayo Clinic: Skin problems, joint disorders top list of reasons people visit doctors
5. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
6. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
7. Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
8. Mayo Clinic: Diabetes can be controlled in patients after pancreas removal
9. Mayo Clinic: Drug duo turns on cancer-fighting gene in kidney, breast cancers
10. Mayo Clinic: Common blood pressure drug linked to severe GI problems
11. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... LINCOLN, R.I. (PRWEB) , ... May 26, 2016 , ... ... season. That’s why Amica Insurance is sharing tips to make sure your ... an estimate from the National Safety Council, there may be 439 deaths and an ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute has partnered with ... class starting June 6 at their clinic in downtown Tampa. The class is complimentary ... Lung Institute has created a free downloadable 4 Week Smoking Cessation Guide ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... of Mehling Orthopedics and chief medical officer of Blue Horizon International (BHI), Brian ... Regeneration. The conference was held during May 5-6, 2016 in Chicago, IL, USA. ...
(Date:5/26/2016)... ... May 26, 2016 , ... Power Systems, a leading developer ... Instructor Certification Course in Stoughton, Massachusetts. The course was led by Power Systems’ ... 8 hour interactive course to qualify participants as certified PowerWave trainers. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... On May 23rd during the National ... Science® and international water advocate, was honored by Ashram, Inc. as the world’s foremost ... who knelt on the banks of the Nile to fill their red clay pots ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... FDA 510(k) clearance covers ... for urological and surgical applications Mauna ... Cellvizio®, the multidisciplinary confocal laser endomicroscopy (CLE) platform, ... US with the 12 th 510(k) clearance ... This new FDA clearance covers Confocal Miniprobes indicated ...
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
(Date:5/25/2016)... 2016  Granger Diagnostics today announced immediate availability of ... infections. This test ensures discovery of ALL bacteria, ... test requires only a simple swab of the wound ... G. Bostwick , MD, Chief Medical Officer, described ... "We are excited to make available, for the ...
Breaking Medicine Technology: