Navigation Links
Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
Date:10/29/2012

BOSTON -- An oral rinse of the antidepressant doxepin significantly eased pain associated with oral mucositis in patients receiving radiation therapy for cancers of the head and neck, a study led by Mayo Clinic found. The findings were presented at the American Society for Radiation Oncology annual meeting in Boston.

MULTIMEDIA ALERT: A video interview with Dr. Miller is available for journalists to download on the Mayo Clinic News Network.

"Oral mucositis or mouth sores is a painful and debilitating side effect of radiation therapy," says principal investigator Robert Miller, M.D., a radiation oncologist at Mayo Clinic. "Our findings represent a new standard of care for treating this condition."

Doxepin rinse does not cause the side effects associated with narcotic pain medicines, Dr. Miller says.

The Phase III study assessed the effectiveness of doxepin oral rinse versus placebo in 155 patients receiving radiation therapy for head and neck cancer. Patients received a single blinded dose of doxepin on day one and crossed over to the opposite study arm on a subsequent day. Patients reported pain associated with oral mucositis on a pain questionnaire with a scale of 0 to 10 administered at baseline and then at five, 15, 30, 60, 120 and 240 minutes after rinsing with doxepin. Patients could continue doxepin after the study, and 64 percent did so. Doxepin was well tolerated, though stinging, burning, unpleasant taste and drowsiness were reported as side effects.


'/>"/>
Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Mayo Clinic: Obesity epidemic fueling rise in rheumatoid arthritis among women
2. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
3. Mayo Clinic: Standard heart disease risk tools underrate danger in rheumatoid arthritis
4. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
5. Mayo Clinic: Common blood pressure drug linked to severe GI problems
6. Mayo Clinic: Drug duo turns on cancer-fighting gene in kidney, breast cancers
7. Mayo Clinic: Diabetes can be controlled in patients after pancreas removal
8. Minorities, Medicare Recipients Less Likely to Get Antidepressants
9. Newer Antidepressants May Be Safe for Parkinsons Patients
10. Publication Bias Casts Doubt on Value of Antidepressants for Autism
11. Antidepressant use associated with increased mortality among critically ill patients?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... 22, 2015 A study recently ... flagship journal Medicine & Science in Sports & ... may help reduce gastrointestinal (GI) problems associated with ... Participants in the double-blind, placebo-controlled study took 10 ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
(Date:1/22/2015)... Colorado (PRWEB) January 22, 2015 Four years since ... Queen – which coincided with the marriage of Avasa & Matthew ... THE ROAD, which is scheduled for release through White Swan Records ... message that there is a sacred path available to all of ...
(Date:1/22/2015)... January 22, 2015 EBSCO Information Services ... are expanding their relationship in an effort to further promote ... world. While EBSCO has long made AMA journals available via ... agent for The JAMA Network. , Long known ...
Breaking Medicine News(10 mins):Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... conducted by Asher Chanan-Khan, MD, Department of Medicine, Roswell ... relapsed chronic lymphocytic leukemia (CLL) or diseases that no ... to the therapy. The results of this study were ... of Clinical Oncology. ,"Chronic lymphocytic leukemia ...
... by U.S firm Schwarz has found to be potential in ... other drugs - the company said on Monday following the ... of the 485-patient study were presented at the North American ... a 200-mg dose of the drug, lacosamide, had 14.4 percent ...
... A new study has challenged the ill-effects of obesity, as ... that being overweight// is a major risk factor for cancer, ... may help in protecting younger women from breast cancer. ... Mass Index results in reduced levels of female hormones, the ...
... the Insecticides Act, 1968 registers pesticides only after satisfying ... data generated under supervised trials is analyzed and used ... of Health & Family Welfare under the Prevention of ... inspection of fruits and vegetables for the presence of ...
... Denis Broun, UNAIDS India coordinator, explained how India’s legal stance ... against HIV/AIDS and is an// infringement of the human rights ... mainly to bring offenders to book, in cases dealing with ... the law is annulled, it may cause a setback to ...
... heart attack Sunday and was taken to a military hospital, ... Pinochet's condition as "serious but stable". ,It said ... were also affected. ,On Nov 25, Pinochet, who ... of supporters gathering outside his home here to congratulate him. ...
Cached Medicine News:
(Date:1/23/2015)... plc (NYSE: MNK ) announced today that ... program. The open-ended authorization permits the company to repurchase ... "Funding additional initiatives and seeking attractive ... to pursue a range of focused growth strategies," said ...
(Date:1/22/2015)... CLEVELAND , Jan. 22, 2015  ViewRay™, a privately ... entered into an exclusive distributor agreement with ITOCHU Corporation ... radiation therapy system for the treatment of cancer in ... (me-rid-i-an) system, is the world,s first and only MRI-guided ...
(Date:1/22/2015)... 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or ... Omega-3 therapies for cardiovascular disease and overall health is pleased ... in 2014 and its outlook for 2015 from the CEO, ... We would like to take this opportunity to ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... 2011 The New Jersey Patient Care and Access Coalition ... encourages men and their families to speak out to preserve ... Force (USPSTF) recommended healthy men should no longer receive prostate-specific ... This decision was made by a panel ...
... 2011 Masimo (NASDAQ: ... Japanese Ministry of Health Labor & Welfare (MHLW) ... rainbow® Acoustic Monitoring technology—providing noninvasive and continuous acoustic ... and enhance patient compliance.  Available for the first ...
Cached Medicine Technology:NJ Docs Say Cancer Detection Tool Saves Lives 2Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 2Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 3Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 4Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 5Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 6
Agility has delivered a RFID-enabled mobile asset management program....
... can provide RFID-enabled tracking and ... medical and surgical supplies. AgileTrac ... track tote deliveries to patient ... track and manage inventories of ...
... RoamAlert Integrity system builds on the ... door controllers in the system are ... a standard Windows® operating system, which ... of a personal computer, RoamAlert Integrity ...
... enterprise visibility solution that allows hospitals ... and increase patient satisfaction. Awarix ... and geospatial visual technologies with your ... real time patient care model that ...
Medicine Products: