Navigation Links
Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
Date:1/8/2013

s multiply in time-lapse video under a microscope, researchers noted that the drug combination resulted in abnormal cell division and an increase in ATC cell death. Although pazopanib had not been known to specifically affect cell division, researchers speculated that the drug might have another unrecognized molecular target within cancer cells.

"We ended up learning that pazopanib also happens to inhibit a protein involved in cell division known as aurora A; this property seems to be involved in producing enhanced effects when pazopanib is combined with paclitaxel," Dr. Bible says. "This finding suggests that the combination may also be useful in treating other cancers, such as breast cancer, in which aurora A is sometimes found to be present in elevated amounts, as it is in ATC," Dr. Bible says.

The results also prompted an ongoing randomized multicenter clinical trial, led by Mayo Clinic and Memorial Sloan-Kettering Cancer Center and administered through the Radiation Therapy Oncology Group, testing the two-drug combination when added to radiation therapy in the initial treatment of patients with anaplastic thyroid cancer.

"This important next step is designed to determine whether the combination of drugs will improve ATC patient survival compared to paclitaxel alone," Dr. Bible says.


'/>"/>

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mayo Clinic: Obesity epidemic fueling rise in rheumatoid arthritis among women
2. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
3. Mayo Clinic: Standard heart disease risk tools underrate danger in rheumatoid arthritis
4. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
5. Mayo Clinic: Common blood pressure drug linked to severe GI problems
6. Mayo Clinic: Drug duo turns on cancer-fighting gene in kidney, breast cancers
7. Mayo Clinic: Diabetes can be controlled in patients after pancreas removal
8. Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
9. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
10. Moffitt researcher investigates 2-drug synergy to treat drug-resistant chronic myeloid leukemia
11. Immunotherapy for elderly cancer patients finds new promise in drug combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... Parents of teenaged and adolescent children might ... latest post discusses Teen Violence Related to Substance Abuse. ... Violence Awareness Month, the substance abuse treatment center has ... parents identify if there may be problems with their ... or alcohol. , “People learn how to establish healthy ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 South Florida’s ... Provisional Certificate of Authority (PCOA) approval from the State ... in the ongoing development of a retirement community that ... health, wellness and spiritual development. , America’s aging population ... meet the housing needs of seniors, according to a ...
(Date:4/1/2015)... Beach, FL (PRWEB) April 01, 2015 ... programs, continues the expansion of its executive team with ... as chief digital officer. , In his ... subscription strategy and user interface across the business and ... distribution partners and building the company’s online community. ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 Boys & ... a national leader in water safety education, today announced ... Deal and the Georgia Children’s Cabinet, that the organizations ... bring water safety skills and swim instruction to thousands ... ZAC Camp. The partnership provides swimming-safety instruction to ...
(Date:4/1/2015)... SkillSurvey, the leading provider of hiring solutions ... the premiere provider of on-line automated reference checking announced ... on “Using Big Data to Recruit Millennials.” The webinar ... of MorseLife, a nationally recognized provider of health care, ... in Palm Beach County. , “As the most tech ...
Breaking Medicine News(10 mins):Health News:Best Drug Rehabilitation Issues Toolkit for Teen Violence Related to Substance Abuse 2Health News:Casa Sant’Angelo Receives Approval for New Retirement Living 2Health News:Addressing The Growing Demand for Interactive, Internet Mindfulness Programs, eMindful Expands Leadership Team With Top Digital Marketing Executive 2Health News:Addressing The Growing Demand for Interactive, Internet Mindfulness Programs, eMindful Expands Leadership Team With Top Digital Marketing Executive 3Health News:Boys & Girls Clubs of America and The ZAC Foundation Announce Third Year of National Partnership to Bring Water Safety Education to 20 Cities Across the Country 2Health News:Boys & Girls Clubs of America and The ZAC Foundation Announce Third Year of National Partnership to Bring Water Safety Education to 20 Cities Across the Country 3Health News:Boys & Girls Clubs of America and The ZAC Foundation Announce Third Year of National Partnership to Bring Water Safety Education to 20 Cities Across the Country 4Health News:SkillSurvey Hiring Expert Series Continues with Webinar Featuring MorseLife 2Health News:SkillSurvey Hiring Expert Series Continues with Webinar Featuring MorseLife 3
... has decreased drastically over the last few decades, we still ... (ACP) President, J. Fred Ralston, Jr., MD, FACP, said as ... Tobacco Control and Prevention, ACP called for a comprehensive federal ... being taken by states currently. "A comprehensive tobacco control ...
... abuse of methamphetamine a powerful and highly addictive ... has reached epidemic proportions in many parts of the ... that more than 10 million Americans have tried methamphetamine, ... Long-term use of the drug can lead ...
... It,s no secret that UVB radiation from the sun ... American Journal of PhysiologyRegulatory, Integrative and Comparative Physiology ... the formation of wrinkles by lessening tissue damage done ... who were placed in an oxygen chamber after exposure ...
... Previous studies have found that the personality ... forethought regarding behaviors, is associated with alcohol use ... during emerging and young adulthood. Some, however, do ... Missouri researchers have found that individuals who exhibited ...
... ... Natural Food Stores and Mainstream Supermarkets Coast-to-Coast. Made from a Blend of Almonds and ... ... of MimicCreme®, announced today the release of its truly dairy-free, non-soy, gluten-free, cholesterol-free, shelf-stable ...
... 2010 -- The National Research Foundation (NRF) of Singapore ... join other leading world universities that have been selected ... CREATE (Campus for Research Excellence and Technological Enterprise) program. ... on cellular and molecular mechanisms of inflammation. The ...
Cached Medicine News:Health News:Internists outline comprehensive federal strategy to control tobacco use 2Health News:Dental school gets $1.86 million from NIH for study of methamphetamine's effect on oral health 2Health News:Hyperoxia may slow formation of wrinkles 2Health News:Large decline in impulsivity in early adulthood related to decrease in alcohol consumption 2Health News:MimicCreme Announces the Release of its Dairy-Free Whipping Cream - HealthyTop and Two New Flavored Coffee Creamers. 2Health News:Hebrew University added to Singapore research program 2
(Date:4/1/2015)... , April 1, 2015  Salix Pharmaceuticals, Ltd. ... International, Inc. (NYSE: VRX ) (TSX:VRX), today ... outstanding $750,000,000 aggregate principal amount of its 6.00% ... (the " Notes ") pursuant to two redemptions. ... aggregate principal amount of the Notes, and on ...
(Date:4/1/2015)... 2015  Daiichi Sankyo, Inc., the US subsidiary of ... merge with its US-based sister company, Asubio Pharmaceuticals, Inc.  ... integrated into the Daiichi Sankyo global development organization, led ... Asubio Pharmaceuticals, parent company, Asubio Pharma Co., Ltd, ... will continue to operate as a wholly owned subsidiary ...
(Date:4/1/2015)... , April 1, 2015 Valeant Pharmaceuticals International, ... today announced the expiration of the tender offer (the ... to purchase all of the outstanding shares of Salix ... price of $173.00 per share in cash, without interest, ... midnight, Eastern time, on April 1, 2015.  Valeant expects ...
Breaking Medicine Technology:Redemption of All of Salix's Outstanding 6.00% Senior Notes due 2021 2Redemption of All of Salix's Outstanding 6.00% Senior Notes due 2021 3Daiichi Sankyo, Inc. and Asubio Pharmaceuticals, Inc. Merge 2Valeant Pharmaceuticals International, Inc. Completes Tender Offer For Salix Pharmaceuticals, Ltd. 2Valeant Pharmaceuticals International, Inc. Completes Tender Offer For Salix Pharmaceuticals, Ltd. 3
Inquiry 4Fr, 5Fr and 6Fr diagnostic electrophysiology catheters offer simple, precise distal control with it's patented Easy-Hand steering mechanism....
... To aid clinicians in performing Ankle/Brachial ... a new, complete packet of information. It ... presentation that can be viewed on any ... the step-by-step procedure of performing an ABI ...
... Advanced engineering, rapid acquisition of ... make it the most accurate autorefractor ... inch High Quality Monitor allows for ... readings are taken as soon as ...
... for Urinary Tract Infection (UTI) ... A multi-center study was conducted ... UTIs. There were 1,887 urine ... and nitrite results of Multistix ...
Medicine Products: