Navigation Links
May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
Date:12/29/2008

While older large series of patients with hepatic granulomas have found sarcoidosis and tuberculosis to be the most common causes of hepatic granulomas, recent works have noted some patients with chronic hepatic C and hepatic granulomas and no other obvious associations. Today, patients that undergo liver biopsy often have chronic hepatitis C that is being staged prior to possible anti viral therapy. The age of HIV and immunosuppression for organ transplants has also made opportunistic infections associated with hepatic granulomas more likely.

A research article to be published on November 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Ned Snyder from the University of Texas medical branch report a retrospective study of over 4 000 liver biopsies as well as a prospective study of 240 patients with chronic hepatitis C undergoing routine liver biopsies. They found that the most common association for hepatic granulomas was chronic hepatitis C. In the prospective study of patients with stable hepatitis C, almost 1% had hepatic granulomas.

In this paper, no reason for the association between granulomas and hepatitis C was found unless granuloma formation is part of the immune response to chronic hepatitis C. Hepatic granulomas have been associated with interferon therapy for hepatitis C and other disorders, but only one patient in the study had received interferon. Granulomas sometimes can develop in intravenous drug users from talc in the injection solution, but examination of the biopsies with polarized light revealed only one patient with crystalloid particles.

The authors concluded that granulomas are an uncommon part of the histologic spectrum of chronic hepatitis C. When granulomas are found in the liver of a patient with chronic hepatitis C, the clinician should be comfortable with the association after other pertinent diseases are excluded.

A reviewer felt this paper is a very good retrospective examination of characteristics associated with hepatogranulomas, with the added strength of the prospective surveillance.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Stem cells from umbilical cord used in the treatment of hepatic diseases
2. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy
3. Attention: Extra-hepatic manifestation of hepatitis C virus infection
4. Cell Therapeutics and Spectrum Pharmaceuticals Close Transaction Forming Joint Venture to Market Zevalin in the US
5. Aimed at Medical Device Makers, FDA Software Development Company Full Spectrum Releases Free Technical Report on Software Protection Technology
6. UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
7. Spectrum Control Receives $1.2 Million Order for Microwave Integrated Assemblies
8. Mayo Clinics new imaging technology accurately identifies a broad spectrum of liver disease
9. Sikorsky Aircraft Recognizes Aero Med Spectrum Health Hospitals
10. Diabetes Spectrum Reports a Study Assessing the i-port(R) Injection Port for Administration of Insulin
11. Marteks lifesDHA(TM) Featured in Four New Products from Spectrum Organics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... Twenty years ago it was revolutionary: ... trying to silence the voices they hear. But this approach has proven transformative, both ... method has steadily gained credibility and now is used around the world, but it ...
(Date:5/31/2016)... Eden Prairie, MN (PRWEB) , ... May 31, 2016 , ... ... accreditation from the American Association for Laboratory Accreditation (A2LA) to include ISO 594-1 and ... the most common means of achieving a leak-free connection between two medical devices (e.g. ...
(Date:5/31/2016)... ... May 31, 2016 , ... Effective leaders not only drive service ... as a whole. On June 2, Northbound CEO Mike Neatherton and COO Paul Alexander ... presenting the opening plenary on “Leadership: The Journey to Authenticity” with Onsite Workshops CEO ...
(Date:5/31/2016)... ... ... The Global Wellness Summit (GWS), an annual conference for international leaders ... spa and beauty in Europe. The organization asked its partner experts in Europe - ... - to forecast where wellness is headed in Europe. Predictions range from European nations ...
(Date:5/31/2016)... Montana (PRWEB) , ... May 31, 2016 , ... Spectrum ... Lift. This new lift has been designed and built with the user in mind. ... of aquatic consultants have informed us that an ADA 400 lbs lift is a ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... , May 31, 2016 The ... is progressing at a CAGR of 10.6% within a ... valued at US$0.46 bn in 2013. Owing to favorable ... to reach US$0.88 bn by the end of this ... from the market,s holistic representation in a research report ...
(Date:5/31/2016)... ZIONA, Israel , May 31, ... medicine company utilizing its proprietary plant-based rhCollagen technology for ... authorization from the Chief Scientist of Israel,s ... of its NIS 12 million development project for 2016. The ... higher than last year,s authorized grant, which totaled NIS ...
(Date:5/30/2016)... India , May 30, 2016 /PRNewswire/ ... market research report "Healthcare Biometrics Market by ... (Signature, Voice)), Multifactor, Multimodal), Application (Workforce Management), ... Forecast to 2021", published by MarketsandMarkets, the ... Million by 2021 from USD 1,182.6 Million ...
Breaking Medicine Technology: