Navigation Links
May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
Date:12/29/2008

While older large series of patients with hepatic granulomas have found sarcoidosis and tuberculosis to be the most common causes of hepatic granulomas, recent works have noted some patients with chronic hepatic C and hepatic granulomas and no other obvious associations. Today, patients that undergo liver biopsy often have chronic hepatitis C that is being staged prior to possible anti viral therapy. The age of HIV and immunosuppression for organ transplants has also made opportunistic infections associated with hepatic granulomas more likely.

A research article to be published on November 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Ned Snyder from the University of Texas medical branch report a retrospective study of over 4 000 liver biopsies as well as a prospective study of 240 patients with chronic hepatitis C undergoing routine liver biopsies. They found that the most common association for hepatic granulomas was chronic hepatitis C. In the prospective study of patients with stable hepatitis C, almost 1% had hepatic granulomas.

In this paper, no reason for the association between granulomas and hepatitis C was found unless granuloma formation is part of the immune response to chronic hepatitis C. Hepatic granulomas have been associated with interferon therapy for hepatitis C and other disorders, but only one patient in the study had received interferon. Granulomas sometimes can develop in intravenous drug users from talc in the injection solution, but examination of the biopsies with polarized light revealed only one patient with crystalloid particles.

The authors concluded that granulomas are an uncommon part of the histologic spectrum of chronic hepatitis C. When granulomas are found in the liver of a patient with chronic hepatitis C, the clinician should be comfortable with the association after other pertinent diseases are excluded.

A reviewer felt this paper is a very good retrospective examination of characteristics associated with hepatogranulomas, with the added strength of the prospective surveillance.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Stem cells from umbilical cord used in the treatment of hepatic diseases
2. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy
3. Attention: Extra-hepatic manifestation of hepatitis C virus infection
4. Cell Therapeutics and Spectrum Pharmaceuticals Close Transaction Forming Joint Venture to Market Zevalin in the US
5. Aimed at Medical Device Makers, FDA Software Development Company Full Spectrum Releases Free Technical Report on Software Protection Technology
6. UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
7. Spectrum Control Receives $1.2 Million Order for Microwave Integrated Assemblies
8. Mayo Clinics new imaging technology accurately identifies a broad spectrum of liver disease
9. Sikorsky Aircraft Recognizes Aero Med Spectrum Health Hospitals
10. Diabetes Spectrum Reports a Study Assessing the i-port(R) Injection Port for Administration of Insulin
11. Marteks lifesDHA(TM) Featured in Four New Products from Spectrum Organics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Somnoware, a leading provider ... Online(TM), which enables sleep physicians to create and edit their interpretation reports. This ... provides a familiar interface that does not require additional training to use. It ...
(Date:4/28/2017)... NY (PRWEB) , ... April 28, 2017 , ... ... Laboratory to expanded distribution of the GlycoMark test throughout the Northeast U.S. ... hyperglycemia in patients with diabetes. The GlycoMark test provides a clinically proven one- ...
(Date:4/28/2017)... york (PRWEB) , ... April 28, 2017 , ... ... to announce that Aditya Patel M.D. has joined the revolutionary endoscopic practice under ... and board certification in Interventional Pain Medicine. The patented, revolutionary eDiscSculpt Technique created ...
(Date:4/28/2017)... ... April 28, 2017 , ... Early detection and ... drug safety and minimize the cost of development. In this webinar, sponsored by ... cell lines and for cardiac toxicity using induced pluripotent stem cells (iPSCs). , ...
(Date:4/28/2017)... ... April 28, 2017 , ... Researchers at ... ActiGraph’s CentrePoint Data Hub in a sample of participants enrolled in ... activity and sleep monitoring solutions for the global scientific community. The company’s new ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 19, 2017 Global Prostate Cancer Therapeutics ... the prostate cancer therapeutics market analyzes the current ... prevalence of prostate cancer, launch of promising emerging ... of new drugs & therapeutic biological products, and ... to lesser side effects are some of the ...
(Date:4/19/2017)... The Global Effective Microorganisms (EM) Market by Manufacturers, ... and analysed the potential of Global Effective Microorganisms (EM) Market ... growth factors. The report identifies and analyses the emerging trends ... market. ... and Figures, 6 Major Company Profiles, spread across 124 pages ...
(Date:4/19/2017)... Companion animal vaccines ... pets such as canine, avian and feline. ... such as Attenuated Live Vaccines, Conjugate Vaccines, Inactivated ... Recombinant Vaccines. Attenuated live vaccines are derived from ... have been weakend under laboratory conditions. Conjugate vaccines ...
Breaking Medicine Technology: