Data support proteomic test as a predictor of overall survival benefit with EGFRI treatment
BROOMFIELD, Colo., May 14 /PRNewswire/ -- Data on VeriStrat, a blood-based, proteomic test currently used for patients with advanced stage non-small-cell lung cancer (NSCLC), will be presented by Christine Chung, MD, Assistant Professor of Medicine at Vanderbilt University on Monday, June 1st at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO). Results from a 314 patient study indicate that VeriStrat is predictive of survival benefit in patients with squamous cell carcinoma of the head and neck (SCCHN) treated with epidermal growth factor inhibitors (EGFRIs). According to the data, VeriStrat provides information to help oncologists identify patients most likely to benefit from EGFRI therapy.
In the study, VeriStrat was used to classify outcomes in patients with SCCHN who were treated with gefitinib (G), erlotinib and bevacizumab (E/B), cetuximab (C), or palliative chemotherapy (PC). Gefitinib, erlotinib and cetuximab are EGFRIs with activity in SCCHN. Results from the study show that among patients treated with EGFRIs, VeriStrat predicted an overall survival benefit (G: p=0.007, HR 0.41; E/B: p=0.02, HR 0.20; C: p=0.06, HR-0.26). VeriStrat did not classify survival outcomes in patients treated with palliative chemotherapy (PC: p=0.76, HR 0.88).
"At present, there are no validated diagnostic tests to guide therapy selection for patients with SCCHN. Having a blood test that provides results which will help oncologists decide whether or not to treat head and neck cancer patients with anti-EGFR agents would be a major advancement in the treatment of this disease," stated Ezra Cohen, MD, Associate Professor of Medicine at the University of Chicago and a study investigator.
The data support previous study results in which VeriStrat effectively identifiedPage: 1 2 3 Related medicine news :1
. American Transplant Congress 2009: New Investigator Forum Presents Cutting Edge Research2
. ESA to Launch Corona(R) ultra(TM) at Pittcon 2009: Booth #10803
. Hospital Build Asia Exhibition and Congress 2009: Regions Most Comprehensive Healthcare Infrastructure Planning and Development Event to Debut in Singapore4
. National Heart Failure Awareness Week February 8-14, 2009: Visit www.abouthf.org to Learn More About Heart Failure5
. Lower Your Grocery Bill, Improve Health In 2009: Top Tips From Dr. Praegers Sensible Foods6
. Pharmacy Technician Certification Board (PTCB) Unveils New Testing Features for 2009: PTCB Exam to be Offered Daily; Test Results Given to Candidates Immediately in 20097
. 2009: The Year of Health Care Reform? Faith-Based Investors See Doubling of Related Shareholder Resolutions, Growing Public Support From Corporate America8
. Nutrition Software nutrinote 2009: Lose Weight With the Help of a Computer9
. NewCardio to Present at OneMedForum 2009: Disrupters and Drivers on January 13 in San Francisco10
. OneMedPlace announces panels for "OneMedForum 2009: Disrupters and Drivers in Eight Areas of Medical Technology" -- CEOs and investors to meet in unique format of focused sessions 11
. SAGE launching new sports medicine journal in 2009: Sports Health: A Multidisciplinary Approach