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Mathematical innovation turns blood draw into information gold mine in Stanford study
Date:3/7/2010

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Analyzing patients' whole blood samples via microarrays without resorting to the new algorithm, the investigators couldn't distinguish any gene-expression pattern differences between the two patient groups. But when they used the new algorithm, they found hundreds of differences in gene expression. Those differences could be used to tell which patients were rejecting their transplants and which were not. Of equal importance, this method let the researchers see that these changes were largely confined to one particular cell type: the monocytes. Only the new virtual-separation technique made fingering this cellular culprit possible.

"It was like a giant arrow pointing to the biological source of the rejection problem," said Davis, the Burton and Marion Avery Family Professor of Immunology and a Howard Hughes Medical Institute investigator.


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Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

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