Navigation Links
Maternal obesity can program fetal brain to induce adult-onset obesity
Date:11/4/2008

have long-term consequences on adult-onset diseases."

Patel and colleagues are pioneers in the investigation of metabolic programming effects when the composition of the diet is manipulated -- changing the percentages of carbohydrates and fat, while keeping calories constant.

Patel reported evidence of metabolic programming in 2002, when his laboratory showed that in rats, consumption of a milk formula high in carbohydrates during the critical early weeks of postnatal life caused permanent changes in pancreatic islets, leading to overproduction of insulin and development of obesity in adulthood.

"Metabolic signals are reset in response to a high carbohydrate milk formula given to newborn rats during the suckling period, which induces permanent changes at the molecular level in our rat model," Patel said. "The HC (high carbohydrate) phenotype is maintained for life and is spontaneously transmitted to succeeding generations."

Unlike many models investigating the role of maternal obesity on their offspring, the mother rats used in this study consumed normal laboratory chow during pregnancy, Patel noted.

"Our findings that malprogramming effects induced during fetal development in the altered intrauterine environment in obese mother rats predispose the offspring for adult-onset obesity underscore the importance of women maintaining optimal conditions during their pregnancies," said Patel.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A childs IQ could be affected by maternal epilepsy
2. Maternal depression and controlling behavior associated with increased stress response in infants
3. Lynn Clark Callister, National Leader in Maternal-Child Health Nursing, Joins March of Dimes Advisory Council
4. Maternal Mortality Declining in Middle-income Countries; Women Still Die in Pregnancy and Childbirth in Low-income Countries
5. MacArthur commits $11 million to further UCSF work in maternal safety
6. A maternal link to Alzheimers disease
7. November issue of Reproductive Health Matters focuses on maternal mortality
8. Maternal Distress Raises Risk of Childhood Asthma
9. Prenatal exposure to maternal antibodies linked to autistic behaviors in offspring
10. Maternal love: How a mothers brain responds to her infant
11. Few Countries on Track to Curb Maternal, Child Mortality Rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... ... like Toppik , Eau Thermale Avene and Bliss are now available on ... required to qualify for free standard shipping,” said Jennifer Ramirez, the public relations manager. ... the item’s selling price.” , With competitive pricing in the e-commerce market for beauty ...
(Date:8/29/2015)... ... ... popular television program VOICES IN AMERICA, hosted by legendary star of the stage and ... segment to the subject of diabetes. Diabetes is a debilitating health condition that is ... advancements in medical science may prove to be a significant breakthrough that sufferers have ...
(Date:8/28/2015)... ... August 28, 2015 , ... Approximately 2,000 ... Zoo to celebrate children helping children, a thank you to the many creative ... have contributed to the United Methodist initiative to end malaria deaths. , The ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... the FDA’s Position and Best Practices for Compliance, **Presented by FDAnews and ... workshop, chaired by internationally renowned expert Fubin Wu, has been specifically designed ...
(Date:8/28/2015)... ... 28, 2015 , ... Saint Petersburg, FL —Pocket Protein™, a ... carbs, sugar, gluten, lactose or caffeine in a convenient 2 oz. pouch that ... Editor’s Choice Awards. , Five consumer packaged goods (CPG) products were selected by ...
Breaking Medicine News(10 mins):Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3
... of Leeds have found a mechanism to prevent a ... ,Dr Lezanne Ooi, a postdoctoral researcher in ... progression of cardiac hypertrophy can be halted by increasing ... a significant discovery because whilst the symptoms can be ...
... church of "consequences" if they vote in favour of overturning a ... the ruling Labor Party in the New South Wales state parliament ... how to vote from Sydney Catholic Archbishop George Pell. ... I'm going to do so by saving a lot of lives, ...
... study at Cincinnati Children's Hospital Medical Center, pediatricians now ... with chronic diseases like Crohn's, juvenile arthritis and ... are at increased risk for bone mass deficiencies, fracture ... is a huge demand for this information among clinicians ...
... GAINESVILLE, Fla. University of Florida researchers report the ... cutting the flow of blood .The talc stimulates ... magic bullet for treating metastatic lung cancer. The UF ... for a cancer largely considered incurable. ,Talcum ...
... they are moving closer to understanding why the most ... to drug treatment in the past three decades. They ... in yeast, a protozoan gene that contributes to such ... a two-year period is believed to be the largest ...
... Chinese President Hu Jintao and U.N. Secretary-General Ban Ki-moon ... (G-8) Summit on Thursday, besides giving India's viewpoint ... climate change. ,An External Affairs Ministry background ... of the world's population, it emits only four per ...
Cached Medicine News:Health News:Breakthrough for Treatment of Fatal Heart Condition 2Health News:Australian Catholics Rebel Over Stem Cell Vote Warning 2Health News:A Pratical Tool to Detect Bone Mass Deficiencies in Children With Chronic Diseases 2Health News:A Pratical Tool to Detect Bone Mass Deficiencies in Children With Chronic Diseases 3Health News:A Pratical Tool to Detect Bone Mass Deficiencies in Children With Chronic Diseases 4Health News:Talcum Powder Curbs Lung Tumor Risk 2Health News:Talcum Powder Curbs Lung Tumor Risk 3Health News:New Insights into Antimalarial Drug Resistance 2Health News:New Insights into Antimalarial Drug Resistance 3Health News:New Insights into Antimalarial Drug Resistance 4Health News:Manmohan Singh to Meet UN Chief, Discuss Climate Change 2
(Date:8/28/2015)... Calif. , Aug. 28, 2015  CytomX Therapeutics, ... treatment of cancer, today announced the filing of a ... and Exchange Commission (SEC) relating to a proposed initial ... shares to be offered and the price range for ... to list its common stock under the symbol "CTMX" ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... announced the addition of the "Investigation Report on ... Developed by Roche under the trade name ... in the world. In Feb.26, 2010, it was approved ... injections available in China all ...
(Date:8/28/2015)... 2015  Today, in final recognition of the Centers ... Week, 1-800 Contacts is sharing how to keep lens ... wearers who do not properly care for their lens ... Most contact lens wearers understand the ... lens case is sometimes overlooked.  When proper steps to ...
Breaking Medicine Technology:CytomX Files Registration Statement for Proposed Initial Public Offering 2Investigation Report on China's Bevacizumab Market 2015-2019 21-800 Contacts Shares Tips on How to Clean Lens Cases 2
... 11, 2012 PLC Systems Inc. (OTCBB: PLCSF), a ... it will demonstrate its innovative product, RenalGuard ® , ... of Percutaneous Cardiovascular Interventions (EAPCI).  More than 11,000 clinicians ... to attend this event in Paris, France from May ...
... SOUTH BEND, Ind., May 11, 2012  Heraeus Kulzer, ... announced that it has launched a new light ... Venus Pearl is indicated for adhesively bonded, tooth-colored ... to its remarkably soft consistency, this new universal ...
Cached Medicine Technology:PLC to Demonstrate RenalGuard® at EuroPCR 2012 2PLC to Demonstrate RenalGuard® at EuroPCR 2012 3Heraeus Launches Remarkably Smooth Venus® Pearl Composite 2Heraeus Launches Remarkably Smooth Venus® Pearl Composite 3
Indications For Usage: ,Bypass upper airway obstructions, provide long term ventilation, support and/or manage tracheal/bronchial secretions....
... The permanent flexible tube extension ... the neck flange helps keep ... chin, and stoma, enhancing patient ... ,Bivona® FlexTend™ tracheostomy tubes improve ...
... TTS™ tracheostomy tubes are available in both neonatal ... like an uncuffed tube, but it has a ... the shaft of the tube. , ,TTS™ ... tube with the insurance of a cuff, if ...
Portex® pediatric tracheostomy tubes offer a choice in both form and fit. , ,The anatomical shape of the tube shaft along with the caudal angle of the 15 mm connector provide comfort and security...
Medicine Products: