Navigation Links
Maternal obesity can program fetal brain to induce adult-onset obesity
Date:11/4/2008

have long-term consequences on adult-onset diseases."

Patel and colleagues are pioneers in the investigation of metabolic programming effects when the composition of the diet is manipulated -- changing the percentages of carbohydrates and fat, while keeping calories constant.

Patel reported evidence of metabolic programming in 2002, when his laboratory showed that in rats, consumption of a milk formula high in carbohydrates during the critical early weeks of postnatal life caused permanent changes in pancreatic islets, leading to overproduction of insulin and development of obesity in adulthood.

"Metabolic signals are reset in response to a high carbohydrate milk formula given to newborn rats during the suckling period, which induces permanent changes at the molecular level in our rat model," Patel said. "The HC (high carbohydrate) phenotype is maintained for life and is spontaneously transmitted to succeeding generations."

Unlike many models investigating the role of maternal obesity on their offspring, the mother rats used in this study consumed normal laboratory chow during pregnancy, Patel noted.

"Our findings that malprogramming effects induced during fetal development in the altered intrauterine environment in obese mother rats predispose the offspring for adult-onset obesity underscore the importance of women maintaining optimal conditions during their pregnancies," said Patel.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A childs IQ could be affected by maternal epilepsy
2. Maternal depression and controlling behavior associated with increased stress response in infants
3. Lynn Clark Callister, National Leader in Maternal-Child Health Nursing, Joins March of Dimes Advisory Council
4. Maternal Mortality Declining in Middle-income Countries; Women Still Die in Pregnancy and Childbirth in Low-income Countries
5. MacArthur commits $11 million to further UCSF work in maternal safety
6. A maternal link to Alzheimers disease
7. November issue of Reproductive Health Matters focuses on maternal mortality
8. Maternal Distress Raises Risk of Childhood Asthma
9. Prenatal exposure to maternal antibodies linked to autistic behaviors in offspring
10. Maternal love: How a mothers brain responds to her infant
11. Few Countries on Track to Curb Maternal, Child Mortality Rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... , ... July 28, 2015 , ... The National ... inductee into its VIP Woman of the Year Circle. She is recognized with this ... for professional women, boasting more than 700,000 members and over 200 operating Local Chapters. ...
(Date:7/27/2015)... ... July 27, 2015 , ... ... in wound center management. Earlier this year Wound Care Advantage beta ... training for WCA wound centers. Customized learning paths allow for clinicians, physicians, ...
(Date:7/27/2015)... ... 27, 2015 , ... The FSH Society , the ... facioscapulohumeral muscular dystrophy (FSHD), today announced the introduction of the first-ever care guideline ... is published today. , This new guideline condenses the results of nearly ...
(Date:7/27/2015)... ... ... Looking to brush up on all the things you should be doing to ... its Dental webpage with new materials, including user-friendly, educational videos, to help members better ... offering our 3.8 million members tools and resources to help them keep a healthy ...
(Date:7/27/2015)... ... July 27, 2015 , ... The Maricopa Community ... out of the foster care system to get into and complete college. , ... was introduced at an event today with partners from across the valley. , The ...
Breaking Medicine News(10 mins):Health News:NAPW Inducts Joanne Saniewski, Principal of the Frontier School District's Big Tree Elementary, Into its VIP Woman of the Year Circle 2Health News:Wound Care Advantage Launches Luvo University An Online Hub For Wound Care Education and Training 2Health News:Wound Care Advantage Launches Luvo University An Online Hub For Wound Care Education and Training 3Health News:First-Ever FSHD Evidence-based Care Guideline Published by the American Academy of Neurology 2Health News:Thinking about a Dental Check-up? Check out Horizon Blue Cross Blue Shield of New Jersey’s Enhanced Website for a Dental Download of Helpful Information 2Health News:Maricopa Community Colleges Launch Program To Help Youth In Foster Care Finish College 2Health News:Maricopa Community Colleges Launch Program To Help Youth In Foster Care Finish College 3
... , MONDAY, July 18 (HealthDay News) -- ... be found by patients themselves, but new research reveals ... by doctors. In the study, conducted by researchers ... the investigators found that in addition to higher rates ...
... Registration is now open for TCT 2011(Transcatheter Cardiovascular ... Foundation, which will return to San Francisco, California, ... advances in interventional cardiology presented at TCT change the ... in the United States, is viewed and treated. Researchers ...
... (HealthDay News) -- Influenza may be far from most Americans, ... but the U.S. Food and Drug Administration said Monday that ... The FDA said it has approved the vaccine formulation ... to produce and distribute the vaccines for the United States. ...
... CHICAGO- A new procedure is now available for the ... lives of more than 18 million Americans. The ... which uses electrical impulses to stimulate the sacral nerve ... the only effective long-term treatments for bowel incontinence available ...
... hospitals spend on environmental services, such as cleaning and ... satisfaction scores as the way the money is spent, ... improving the efficiency of operations, hospitals can contribute to ... the financial investments they make toward support services," said ...
... 18 (HealthDay News) --, Women fear Alzheimer,s disease more than ... on the front lines of providing care for loved ones ... pointing to the fact that more women are living with ... women are disproportionately affected by this disease," said Angela Geiger, ...
Cached Medicine News:Health News:Specialists More Likely to Spot Deadly Skin Cancer 2Health News:Innovations in cardiovascular therapies and treatments will be presented at TCT 2011 2Health News:FDA Unveils Flu Vaccines for 2011-12 Season 2Health News:New therapy provides hope for millions of people suffering from bowel incontinence 2Health News:Value of hospital environmental services linked to efficiency not expenses 2Health News:Value of hospital environmental services linked to efficiency not expenses 3Health News:Women Bear Greatest Burden of Alzheimer's 2
(Date:7/27/2015)... 2015  Cardica, Inc. (Nasdaq: CRDC ) today announced ... quarter ended June 30, 2015, on Thursday, August 6, 2015, ... call at 4:30 p.m. Eastern Time to discuss the financial ... Conference Call Details To access the live conference ... via phone, please dial 877-703-6106 from the United ...
(Date:7/27/2015)... 27, 2015 Syneron Medical Ltd. ... global market leader in the aesthetic medical device marketplace, ... Food and Drug Safety (MFDS) regulatory clearance for the ... can fulfill PicoWay orders from its Korean distribution partner, ... in the third quarter 2015. Amit Meridor, ...
(Date:7/27/2015)... 27, 2015  Relmada Therapeutics, Inc. (OTCQB: RLMD), ... treatment of chronic pain, today announced that it ... Heath Canada to conduct a multiple ... REL-1017), its novel, N-methyl-D-aspartate (NMDA) receptor antagonist being ... "We are very encouraged by the initial ...
Breaking Medicine Technology:Cardica To Announce Fiscal 2015 Fourth Quarter Financial Results On Thursday, August 6, 2015 2Syneron Receives Korean MFDS Regulatory Clearance for PicoWay Picosecond Laser 2Syneron Receives Korean MFDS Regulatory Clearance for PicoWay Picosecond Laser 3Syneron Receives Korean MFDS Regulatory Clearance for PicoWay Picosecond Laser 4Relmada Therapeutics Announces Filing of Clinical Trial Application in Canada for Multiple Ascending Dose Study with Promising NMDA Receptor Antagonist d-Methadone 2Relmada Therapeutics Announces Filing of Clinical Trial Application in Canada for Multiple Ascending Dose Study with Promising NMDA Receptor Antagonist d-Methadone 3
... Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ) ... September 30, 2011 and provided a business update.  The ... and 2010, as reported in accordance with accounting principles ... million and $0.6 million, respectively.  The net losses for ...
... 7, 2011 Planet Biopharmaceuticals, Inc. and its wholly ... company focused on providing products for allergy and asthma ... sale of ALLERGY CONTROL PRODUCTS, INC., a Delaware corporation("ACP") ... liability company. Theron E. Odlaug, Ph. D., ...
Cached Medicine Technology:Alexza Reports 2011 Third Quarter Financial Results and Provides Business Update 2Alexza Reports 2011 Third Quarter Financial Results and Provides Business Update 3Alexza Reports 2011 Third Quarter Financial Results and Provides Business Update 4Alexza Reports 2011 Third Quarter Financial Results and Provides Business Update 5Alexza Reports 2011 Third Quarter Financial Results and Provides Business Update 6Alexza Reports 2011 Third Quarter Financial Results and Provides Business Update 7
... preventative/thera-peutic device for wearing during sports ... vibration and shock often transmitted during ... relief from painful symptoms of tennis ... detachable from the brush lined encircling ...
... Bracing options for controlling range of ... Design is better known for its lower ... increasing number of patients have benefitted from ... , ,Townsends ROM Series post-operative elbow ...
Premium Tennis Elbow Support is 2" wide with loop-lock contact closure and is foam-lined for comfort....
... new "Innovation Joint Technology" elbow brace has ... specialists to help re-establish pain free range ... has been engineered to provide the clinician ... rotation forces. Treatment use includes Wrist and ...
Medicine Products: