Navigation Links
Maternal obesity can program fetal brain to induce adult-onset obesity
Date:11/4/2008

BUFFALO, N.Y. -- Researchers at the University at Buffalo have found that fetuses of obese mother rats were programmed in utero to develop obesity in adulthood.

Moreover, they have shown for the first time that the metabolic programming occurs in the fetal hypothalamus, the area of the brain responsible for maintaining the body's energy homeostasis (body weight) throughout life.

Levels of the hormones insulin and leptin also were elevated in fetuses of these obese mother rats, abnormalities that have been correlated with increased appetite and insulin resistance (a prelude to diabetes), as well as obesity and hypertension.

"Our earlier studies looked at newborn rats of the obese mothers in the post-weaning period, so we didn't know how early this programming occurred," said Mulchand Patel, Ph.D., UB Distinguished Professor of Biochemistry and senior author on the study. "Now we know it occurs in utero and specifically in the hypothalamus.

"While these studies were done with rats, there is good reason to think the mechanism would be similar in humans," he said. " The fact that more than one-third of women of child-bearing age in the United States are expected to be overweight or obese during pregnancy, based on a 2003 study, does not portend well for good health of their offspring."

The new findings were published in the October 2008 issue of the American Journal of Physiology, Endocrinology and Metabolism. Malathi Srinivasan, Ph.D., research scientist in the UB Department of Biochemistry, is first author.

Metabolic programming, sometimes called dietary patterning, isn't a new phenomenon, Patel noted. "Epidemiologic studies of malnourished mothers showed that their babies often were underweight and at increased risk for several chronic diseases as adults. Animal studies on maternal protein malnourishment or caloric restriction have shown that pre- and immediate postnatal nutritional modifications have long-term consequences on adult-onset diseases."

Patel and colleagues are pioneers in the investigation of metabolic programming effects when the composition of the diet is manipulated -- changing the percentages of carbohydrates and fat, while keeping calories constant.

Patel reported evidence of metabolic programming in 2002, when his laboratory showed that in rats, consumption of a milk formula high in carbohydrates during the critical early weeks of postnatal life caused permanent changes in pancreatic islets, leading to overproduction of insulin and development of obesity in adulthood.

"Metabolic signals are reset in response to a high carbohydrate milk formula given to newborn rats during the suckling period, which induces permanent changes at the molecular level in our rat model," Patel said. "The HC (high carbohydrate) phenotype is maintained for life and is spontaneously transmitted to succeeding generations."

Unlike many models investigating the role of maternal obesity on their offspring, the mother rats used in this study consumed normal laboratory chow during pregnancy, Patel noted.

"Our findings that malprogramming effects induced during fetal development in the altered intrauterine environment in obese mother rats predispose the offspring for adult-onset obesity underscore the importance of women maintaining optimal conditions during their pregnancies," said Patel.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
Source:Eurekalert

Related medicine news :

1. A childs IQ could be affected by maternal epilepsy
2. Maternal depression and controlling behavior associated with increased stress response in infants
3. Lynn Clark Callister, National Leader in Maternal-Child Health Nursing, Joins March of Dimes Advisory Council
4. Maternal Mortality Declining in Middle-income Countries; Women Still Die in Pregnancy and Childbirth in Low-income Countries
5. MacArthur commits $11 million to further UCSF work in maternal safety
6. A maternal link to Alzheimers disease
7. November issue of Reproductive Health Matters focuses on maternal mortality
8. Maternal Distress Raises Risk of Childhood Asthma
9. Prenatal exposure to maternal antibodies linked to autistic behaviors in offspring
10. Maternal love: How a mothers brain responds to her infant
11. Few Countries on Track to Curb Maternal, Child Mortality Rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... ... Area in Alabama are expected to attend the UNCF Dothan-Wiregrass Mayor’s Luncheon Dec. ... scholarship funds for area students and operating support to UNCF-member institutions, including Miles ...
(Date:12/2/2016)... ... December 02, 2016 , ... Center for Autism and ... of those affected by autism spectrum disorder (ASD) and other developmental disabilities. The group, ... will give parents and other caregivers the opportunity to share stories and advice, seek ...
(Date:12/2/2016)... ... , ... With the number of pain management programs available for people suffering ... one that works for them. When an inventor from Suisun City, Calif., was unsuccessful ... to share it with others. , He developed a prototype for PRO GO MASSAGE ...
(Date:12/2/2016)... ... 02, 2016 , ... More than half of American teens report losing their ... speaking with their child about sex related topics, less than 60 percent spoke about ... to announce the launch of its second edition of the “Sexual Wellness” campaign, aiming ...
(Date:12/2/2016)... Honolulu, Hawaii (PRWEB) , ... December 02, 2016 ... ... 3, 2016 at the Hyatt Regency Waikiki Beach Resort and Spa in Honolulu, ... (CME) in the field of pain management. , The demand for supplemental ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... DUBLIN , Dec 2, 2016 Research ... Pipeline Database" newsletter to their offering. ... , , ... La Merie Publishing,s proprietary R&D Drug Pipeline Database provides 24/7 online ... therapeutic drugs on the market and on investigational drug candidates in ...
(Date:12/2/2016)... the largest share in the ECG Cables And ECG Leadwires ... remote monitoring ECG devices. On the other hand, the ... the highest growth rate during the forecast period. ... Company (U.S.), Medtronic plc ( Ireland ), Koninklijke ... Medical International Limited ( China ), held major ...
(Date:12/2/2016)... Quantum Radiology,s Mobile Breast Center (QR MBC) brings cutting-edge ... at the workplace, thereby maximizing convenience and compliance.  QR ... and SunTrust Bank, and community health groups to provide ... "I think it,s a great service for ... a mammogram without taking a large amount of time ...
Breaking Medicine Technology: