Navigation Links
Maternal obesity can program fetal brain to induce adult-onset obesity
Date:11/4/2008

BUFFALO, N.Y. -- Researchers at the University at Buffalo have found that fetuses of obese mother rats were programmed in utero to develop obesity in adulthood.

Moreover, they have shown for the first time that the metabolic programming occurs in the fetal hypothalamus, the area of the brain responsible for maintaining the body's energy homeostasis (body weight) throughout life.

Levels of the hormones insulin and leptin also were elevated in fetuses of these obese mother rats, abnormalities that have been correlated with increased appetite and insulin resistance (a prelude to diabetes), as well as obesity and hypertension.

"Our earlier studies looked at newborn rats of the obese mothers in the post-weaning period, so we didn't know how early this programming occurred," said Mulchand Patel, Ph.D., UB Distinguished Professor of Biochemistry and senior author on the study. "Now we know it occurs in utero and specifically in the hypothalamus.

"While these studies were done with rats, there is good reason to think the mechanism would be similar in humans," he said. " The fact that more than one-third of women of child-bearing age in the United States are expected to be overweight or obese during pregnancy, based on a 2003 study, does not portend well for good health of their offspring."

The new findings were published in the October 2008 issue of the American Journal of Physiology, Endocrinology and Metabolism. Malathi Srinivasan, Ph.D., research scientist in the UB Department of Biochemistry, is first author.

Metabolic programming, sometimes called dietary patterning, isn't a new phenomenon, Patel noted. "Epidemiologic studies of malnourished mothers showed that their babies often were underweight and at increased risk for several chronic diseases as adults. Animal studies on maternal protein malnourishment or caloric restriction have shown that pre- and immediate postnatal nutritional modifications
'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A childs IQ could be affected by maternal epilepsy
2. Maternal depression and controlling behavior associated with increased stress response in infants
3. Lynn Clark Callister, National Leader in Maternal-Child Health Nursing, Joins March of Dimes Advisory Council
4. Maternal Mortality Declining in Middle-income Countries; Women Still Die in Pregnancy and Childbirth in Low-income Countries
5. MacArthur commits $11 million to further UCSF work in maternal safety
6. A maternal link to Alzheimers disease
7. November issue of Reproductive Health Matters focuses on maternal mortality
8. Maternal Distress Raises Risk of Childhood Asthma
9. Prenatal exposure to maternal antibodies linked to autistic behaviors in offspring
10. Maternal love: How a mothers brain responds to her infant
11. Few Countries on Track to Curb Maternal, Child Mortality Rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 21, 2014 (HealthDay News) -- The United States ... from Ebola-affected nations of West Africa land at ... for infection with the virus. In a ... noted that 94 percent of air passengers from ... one of these five airports -- New York ...
(Date:10/22/2014)... During the Western United States’ worst ... dangerously low, Southern Oregon’s water is proving resistant to ... lowest mountain snow pack on record in 2014, remain ... autumn.* That was the observation of journalist-hikers Art Bernstein ... Southern Oregon,” during an interview with water advocate Sharon ...
(Date:10/22/2014)... Mission Viejo, CA (PRWEB) October 22, 2014 ... that Jay Cormier, Sr. Vice President of Sales, will ... at the upcoming Meetings Technology Expo on October 28, ... will also be hosting a booth as well as ... on how Lintelus Meeting can create a more engaging ...
(Date:10/22/2014)... Two sisters in high school have developed ways to ... Krishen use electronic stethoscopes, which electronically amplify body sounds, ... or heartbeats. Ilina, a senior at Port Huron ... way to detect early lung damage in people exposed ... recorded one breath cycle each from 16 smokers, 25 ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 (HealthDay News) -- ... NBC News in Liberia has cleared the virus from ... Medical Center in Omaha, where he had been treated for the ... confirmed by the U.S. Centers for Disease Control and Prevention found ... NBC News reported Tuesday night. "Recovering from Ebola is ...
Breaking Medicine News(10 mins):Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3
... had a 90 per cent chance of developing breast cancer, due ... January this year she became the youngest woman in Britain to ... have done so. ,Becky a radio presenter was 11 ... first women in the country to undergo a double mastectomy to ...
... free personal care for the elderly was planned as a ... dignity and security //for everyone in old age. But now ... funding. Many medical councils are alleging that they have already ... this week it was reported that more than 200 pensioners ...
... find out about the breast cancer in younger black women ... with the white women the number of black women affected ... mortality rate among the black women is much higher when ... the age of 50 have a 77 percent of mortality ...
... NHS computer link, which was to have cost ?6.2 billion, ... projects//. Experts say this is a waste of the taxpayers' ... University Computing Laboratory, said, 'This programme shows many signs that ... about computer products being used in a way that manufacturers ...
... sign an MoU with private practitioners and medical colleges ... World Bank aided Rs 2.17 crore Integrated Disease Surveillance ... signed between the state health department and private practitioners ... stakeholder would need to play in the programme, Haryana ...
... the proprietor of a medical store, who was missing for the ... today. // ,Pradeep Goyal's body was handed over to ... on Friday morning and since then his whereabouts remained obscure, police ... him., ,On Monday, police were informed that the body of ...
Cached Medicine News:Health News:A 24 Year Old Girls Undergoes Double Mastectomy To Prevent Breast Cancer 2Health News:Breast Cancer Mortality Rate is Higher Among Black Women 2Health News:Breast Cancer Mortality Rate is Higher Among Black Women 3
(Date:10/22/2014)... , Oct. 21, 2014   BioNano ... the latest genomics research centers to purchase an ... Institute, the National Cancer Institute (NCI), NIH Intramural ... Center). Before Irys, obtaining a comprehensive view of ... generation sequencing (NGS) does not deliver the scalability ...
(Date:10/22/2014)... Mass. , Oct. 22, 2014 InVivo ... Cambridge, MA is revolutionizing spinal cord injury ... has been shown to outperform in tissue regrowth in ... the scaffold.  Made from an FDA approved polymer, the ... making it harmless to the human body. NVIV has ...
(Date:10/22/2014)... , Oct. 22, 2014  AcelRx Pharmaceuticals, Inc. ... results from the  IAP310 study have been published ... a peer-reviewed journal with broad, multidisciplinary readership. ... evaluating the safety and efficacy of Zalviso, also ... (SSTS), for the treatment of post-operative pain in ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 3AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2
... 2011 STAAR Surgical Company (Nasdaq: ... of minimally invasive ophthalmic products, today announced that ... in patients has exceeded 200,000.  Since 1994, STAAR,s ... refractive eye surgery as an alternative to LASIK. ...
... Corporation (Nasdaq: PRXL ) announced today it will ... Francisco.  Josef von Rickenbach, Chairman and Chief Executive Officer will ... on Thursday, January 13, 2011. A live webcast ... section of PAREXEL,s website at www.PAREXEL.com in ...
Cached Medicine Technology:STAAR Surgical's Visian® ICL Surpasses 200,000 Implants 2STAAR Surgical's Visian® ICL Surpasses 200,000 Implants 3PAREXEL International to Present at J.P. Morgan Healthcare Conference 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: