Navigation Links
Master regulator of key cancer gene found, offers new drug target
Date:6/25/2014

MINNEAPOLIS/ST. PAUL (June 23, 2014) A key cancer-causing gene, responsible for up to 20 percent of cancers, may have a weak spot in its armor, according to new research from the Masonic Cancer Center, University of Minnesota.

The partnership of MYC, a gene long linked to cancer, and a non-coding RNA, PVT1, could be the key to understanding how MYC fuels cancer cells. The research is published in the latest issue of the journal Nature.

"We knew MYC amplifications cause cancer. But we also know that MYC does not amplify alone. It often pairs with adjacent chromosomal regions. We wanted to know if the neighboring genes played a role," said lead author Anindya Bagchi, Ph.D., assistant professor in the University of Minnesota Medical School, the College of Biological Sciences and member of the Masonic Cancer Center. "We took a chance and were surprised to find this unexpected and counter-intuitive partnership between MYC and its neighbor, PVT1. Not only do these genes amplify together, PVT1 helps boost the MYC protein's ability to carry out its dangerous activities in the cell."

Contributors to this research include Yuen-Yi Tseng, graduate student with Anindya Bagchi, David Largaespada, Ph.D., professor in the College of Biological Sciences, Yasuhiko Kawakami, Ph.D., assistant professor in the College of Biological Sciences, York Marahrens, Ph.D., associate professor in the College of Biological Sciences and Kathryn Schwertfeger, Ph.D., assistant professor in the University of Minnesota's Medical School.

Bagchi and his team focused on a region of the genome, 8q24, which contains the MYC gene and is commonly expressed in cancer. The team separated MYC from the neighboring region containing the non-coding RNA PVT1. Using a specialized gene manipulation technique called chromosome engineering, researchers developed genetically engineered mouse strains in three separate iterations: MYC only, the rest of the region containing
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. McMaster researchers find potential for new uses of old drug
2. US Army internal medicine Masters, Fellows honored by American College of Physicians
3. McMaster University researchers discover drug destroys human cancer stem cells but not healthy ones
4. ESA start-up company wins GMES Masters award
5. Barry D. Rutherford, M.D. presented with Master Clinical Operator Award at TCT 2012
6. Mastering weight-maintenance skills before embarking on diet helps women avoid backsliding
7. Metro Atlanta ServiceMasters Team Up to Offer Higher Quality of Water Damage, Mold Removal, Carpet Cleaning and Fire Damage Services to Customers in North Georgia
8. Renowned Master of Wine Jeannie Cho Lee Appointed Professor of Practice (Wine) by PolyU
9. Floodmasters 5 Tips to Surviving the Next Hurricane Sandy
10. New ChairMaster™ Fitness Chair Lets Users Sit and Get Fit
11. Exam Master® Offers New USMLE Step 1 Premium Practice Exam
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... July 28, 2015 , ... Safeguard Scientifics, ... the Company, from time to time and depending on market conditions, to repurchase ... $25 million. Repurchases will be made in open market or privately negotiated transactions ...
(Date:7/28/2015)... New York, NY (PRWEB) , ... July 28, ... ... specialty benefit management services to include a proprietary, web based clinical knowledge system, ... algorithms that are evidence based. It provides physicians who are anticipating making ...
(Date:7/28/2015)... GA (PRWEB) , ... July 28, 2015 , ... ... been chosen as a “Top Doctor 2015” by Atlanta Magazine. In Atlanta Magazine's annual ... row by hundreds of her esteemed colleagues and peers in the metro area as ...
(Date:7/28/2015)... ... 2015 , ... A new study published by HealthDay News on June 24, ... on a possible new treatment option for people living with fibromyalgia – hyperbaric oxygen ... least five per week, patients experienced a significant decrease in pain, fatigue, and other ...
(Date:7/28/2015)... , ... July 28, 2015 , ... ... Coronary Syndromes (ACS-Heart Attack, Sudden Death, or Angina), many of whom are missed ... the identification of individuals with active yet undetected sub-clinical disease, who are at ...
Breaking Medicine News(10 mins):Health News:Safeguard Scientifics Board of Directors Authorizes up to $25 Million Share Repurchase Program 2Health News:Safeguard Scientifics Board of Directors Authorizes up to $25 Million Share Repurchase Program 3Health News:Introducing Care to Care’s New Web Based “Referral Guidance” Program 2Health News:Atlanta Fertility Specialist Named Top Doctor in Atlanta Magazine 2Health News:Atlanta Fertility Specialist Named Top Doctor in Atlanta Magazine 3Health News:Recovery Specialists Discuss How Oxygen Therapy Can Ease Fibromyalgia 2Health News:Recovery Specialists Discuss How Oxygen Therapy Can Ease Fibromyalgia 3Health News:Utility of a novel coronary artery disease biomarker algorithm in modifying physician adherence to guideline therapy presented at 20th World Congress on Heart Disease 2
... a foul mist drifted onto the playground from the adjacent ... , vomiting on the blacktop. ,Apparently hundreds of ... farm chemicals, leading to sickness, brain damage and birth defects. ... spraying near schools, and advocates say California and the seven ...
... (USC) researchers have shown that patients with Parkinsons disease ... exercises. ,Dr. Michael Jakowec, Assistant Professor ... the effects of treadmill exercise between animal models with ... similar to what Parkinson's patients might suffer. ...
... Queensland University of Technology has revealed that airborne viruses can ... director of QUT's International Laboratory for Air Quality and Health, ... humans only travel a metre in the air. ... been studying the way droplets carrying viruses are dispersed in ...
... spot of milk to the black tea will not spoil ... ,Earlier studies have suggested that milk can ruin the ... ,However a team of researchers led by Janet Kyle at ... debunks the earlier findings. ,As a part of ...
... a body mass index (BMI) in the overweight or obese ... employer-sponsored weight loss and maintenance programs should be considered as ... is a measure of body fat based on an adult's ... categories that may lead to health problems. According to the ...
... saliva may be a biological indicator of the trauma ... by peers. ,The researchers believe ... and intervention of long-term psychological effects on youth. ... or observed by teachers,' said JoLynn V. Carney, Associate ...
Cached Medicine News:Health News:Hundreds of Children Exposed to Pesticide in US 2Health News:Hundreds of Children Exposed to Pesticide in US 3Health News:Out of Reach may Not Always Save You from Catching Cold 2Health News:Risk of Traumatic Workplace Injury Increased by Obesity 2Health News:Saliva Helps to Identify Child Victims of Chronic Bullying 2
(Date:7/28/2015)...  CryoLife, Inc. (NYSE: CRY ), a leading ... and vascular surgery, announced today its results for the ... Pat Mackin, Chairman, President and Chief Executive ... on our growth strategy with solid progress on several ... plans to transition to a direct sales model in ...
(Date:7/28/2015)... -- ANI Pharmaceuticals, Inc. (NASDAQ: ANIP ) announced ... quarter and year-to-date 2015 financial results on Tuesday, August ... markets. The earnings press release will be accessible through ... www.anipharmaceuticals.com . Arthur S. Przybyl , ... Arnold , Vice President and Chief Financial Officer, also ...
(Date:7/28/2015)... HACKENSACK, N.J., July 28, 2015  Champions Oncology, Inc. ... solutions and services to personalize the development and use ... the year ended April 30, 2015. Fourth ... increased 32% over the same prior year period result ... than 140 implants Joel Ackerman, Champions Oncology ...
Breaking Medicine Technology:CryoLife Reports Second Quarter Financial Results 2CryoLife Reports Second Quarter Financial Results 3CryoLife Reports Second Quarter Financial Results 4CryoLife Reports Second Quarter Financial Results 5CryoLife Reports Second Quarter Financial Results 6CryoLife Reports Second Quarter Financial Results 7CryoLife Reports Second Quarter Financial Results 8CryoLife Reports Second Quarter Financial Results 9CryoLife Reports Second Quarter Financial Results 10CryoLife Reports Second Quarter Financial Results 11CryoLife Reports Second Quarter Financial Results 12CryoLife Reports Second Quarter Financial Results 13CryoLife Reports Second Quarter Financial Results 14ANI Pharmaceuticals Schedules Conference Call for Second Quarter and Year-to-Date 2015 Financial Results 2Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 2Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 3Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 4Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 5Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 6Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 7Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 8Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 9Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 10Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 11
... 19, 2007 - Amgen,(NASDAQ: AMGN) today ... study", a,randomized, double-blind, placebo-controlled, multicenter Phase ... 600 previously untreated,patients with extensive-stage small-cell ... study demonstrated,no statistically significant difference in ...
... Biomolecular Sciences Conference, THE WOODLANDS, Texas, April ... that data was presented,today highlighting potential therapeutic ... at the Society for Biomolecular,Sciences 13th Annual ... discoveries were made in a collaboration,between Lexicon ...
Cached Medicine Technology:Aranesp ``145 Study'' Shows No Difference in Survival in Patients,with Small-Cell Lung Cancer 2Aranesp ``145 Study'' Shows No Difference in Survival in Patients,with Small-Cell Lung Cancer 3Aranesp ``145 Study'' Shows No Difference in Survival in Patients,with Small-Cell Lung Cancer 4Aranesp ``145 Study'' Shows No Difference in Survival in Patients,with Small-Cell Lung Cancer 5Aranesp ``145 Study'' Shows No Difference in Survival in Patients,with Small-Cell Lung Cancer 6Aranesp ``145 Study'' Shows No Difference in Survival in Patients,with Small-Cell Lung Cancer 7Lexicon-Genentech Collaboration Yields Potential Therapeutic,Targets 2Lexicon-Genentech Collaboration Yields Potential Therapeutic,Targets 3Lexicon-Genentech Collaboration Yields Potential Therapeutic,Targets 4Lexicon-Genentech Collaboration Yields Potential Therapeutic,Targets 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: