Navigation Links
Mast cells give clues in diagnosis, treatment of dengue
Date:4/30/2013

DURHAM, N.C. -- A protein produced by mast cells in the immune system may predict which people infected with dengue virus will develop life-threatening complications, according to researchers at Duke Medicine and Duke-National University of Singapore (Duke-NUS).

Their study also found that in experiments in mice, a class of drugs commonly used to treat asthma by targeting the mast cells could help treat vascular symptoms associated with dengue infections. The findings were published in the online journal eLife on April 30, 2013.

Dengue virus is spread by mosquitoes and infects as many as 390 million people worldwide each year, according to new estimates published in the journal Nature. It is a significant health issue in tropical areas of the world including parts of Latin America and Asia, but Florida residents have reported cases in recent years.

No treatments are available for dengue virus, and serious cases can result in widespread vascular leakage and hemorrhaging.

In 2011, Duke researchers reported that mast cells, which help the body respond to bacteria and other pathogens, play a role in attacking dengue virus and halting its spread. This finding presented new avenues for research, given the existing classes of drugs that target mast cells or the products of mast cells once they are activated.

In one experiment in the current study of dengue virus in mice, the researchers found that certain classes of drugs commonly used to treat asthma are effective in limiting vascular leakage associated with dengue.

"It may not seem intuitive how asthma and dengue infection would be related and would respond to the same types of drugs, but because both diseases are promoted by mast cells, the cellular targets of the class of drugs is quite effective," said lead author Ashley L. St. John, PhD, assistant professor of emerging infectious diseases at Duke-NUS.

The researchers continued to inve
'/>"/>

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Battery of tests on cancer cells shows them as squishy, yet tactically strong
2. New research findings on the brains guardian cells
3. Virus kills melanoma in animal model, spares normal cells
4. Screening detects ovarian cancer using neighboring cells
5. Method makes it easier to separate useful stem cells from problem ones for therapies
6. £2million project aims to revolutionize the study of cancer cells in the lab
7. Metastasis stem cells in the blood of breast cancer patients discovered
8. Voices Against Brain Cancer Comments on New Study Claiming Fat Tissue Stem Cells can Fight Brain Cancer
9. Ultrasound Waves, Bone Marrow Cells Show Promise in Heart Failure Patients
10. Stanford researchers turn skin cells directly into the cells that insulate neurons
11. Stem Cells to Relieve Low Back Pain?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... July 30, 2015 , ... ... people on the go. With no water needed, the refreshing berry-flavored tablets are ... way to get the natural ingredients that may help with body detoxification, protection ...
(Date:7/30/2015)... ... July 30, 2015 , ... Mullin/Ashley Associates, Inc. ... three awards in the Service Industry Advertising Awards 12th annual national competition. ... Development Corporation and University of Maryland Shore Regional Health. , A Gold Award ...
(Date:7/30/2015)... ... July 30, 2015 , ... Well-known San Diego ... largest, family-owned low cost service and repair companies. For 35 years, they have ... growing their company to meet the demands of the changing technological environment. ...
(Date:7/30/2015)... , ... July 30, 2015 , ... 24/7 Care At ... Riverside, and San Bernardino, recently announced that the Centers for Medicare and Medicaid (CMS) ... of home health care providers. 24/7 Care At Home’s agency is one of three ...
(Date:7/30/2015)... Dallas, TX (PRWEB) , ... July 30, 2015 ... ... Experience Grant Program and fourth annual Institute Scholar Program. In partnership with Patient ... field of patient experience, develop leaders on the front lines and throughout the ...
Breaking Medicine News(10 mins):Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 3Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 4Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 2Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 3Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 2Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 3Health News:24/7 Care At Home Earns a 5-Star Rating from the Centers for Medicare and Medicaid (CMS) 2Health News:The Beryl Institute Opens Applications for 2015 Patient Experience Grant and Scholar Programs 2Health News:The Beryl Institute Opens Applications for 2015 Patient Experience Grant and Scholar Programs 3
... Therapeutic Radiology and Oncology is pleased to announce that ... of,Uruguay, will present a special guest lecture at ASTRO,s ... Los Angeles. Dr. Vazquez, who,is a radiation oncologist by ... 30 at 9:00 a.m. at the Los Angeles Convention,Center ...
... more food is needed, study suggests , , WEDNESDAY, Oct. ... DNA to blame, research suggests. , Scientists from the ... of dopamine, a brain chemical that helps make eating ... consume more food. , "We weren,t studying obesity, per ...
... Medical,International Limited (NYSE: MR ), a leading developer, ... that it will report,its third quarter 2007 financial results ... management will hold an earnings conference,call at 8:00 PM ... on November,2, 2007 Beijing/Hong Kong Time). Dial-in details ...
... "As a physician,you hear all sorts of excuses for ... Medical Director of First Coast Family Medicine and clinical,spokesperson ... common that Dr. Hashey reports is the excuse that ... couldn,t be farther from the truth.,The flu shot is ...
... For the Nine Months (to 31 August) a 46% Sales Increase ... EBIT to EUR34.8m (EUR6.2m) - Marked Improvement in Adjusted EBITDA ... in Interest Charges Since the IPO - CEO Dr. Axel ... In the first nine months of its financial year (to 31 ...
... Speaker Nancy Pelosi,will hold a press availability tomorrow, Wednesday, ... their daughter, Bethany, a 2-year-old,from Tampa, Fla., who was born ... health care. The family is on Capitol Hill urging Members ... bipartisan SCHIP,bill that covers 10 million children., WHO: ...
Cached Medicine News:Health News:President of Uruguay to Speak at ASTRO Annual Meeting 2Health News:Genes Might Help Drive Overeating 2Health News:Genes Might Help Drive Overeating 3Health News:Mindray to Report Third Quarter 2007 Financial Results on November 1, 2007 2Health News:Flu Myths Abound in Flu Season 2Health News:Growth Trend for Gerresheimer Continues Unabated - Debt Reduction 2Health News:Growth Trend for Gerresheimer Continues Unabated - Debt Reduction 3Health News:Growth Trend for Gerresheimer Continues Unabated - Debt Reduction 4Health News:Growth Trend for Gerresheimer Continues Unabated - Debt Reduction 5
(Date:7/30/2015)... SAN DIEGO , July 30, 2015  Arena ... will host a conference call and webcast at 5:00 ... August 5, 2015, to discuss second quarter 2015 financial ... its financial results after the NASDAQ Global Select Market ... be accessed by dialing 877.643.7155 for domestic callers and ...
(Date:7/30/2015)... 30, 2015  Cardinal Health today reported fourth-quarter ... increase of 20 percent, and non-GAAP diluted earnings ... an increase of 20 percent. Non-GAAP operating earnings ... GAAP basis, operating earnings increased 44 percent to ... increased 29 percent to $0.88. Fiscal ...
(Date:7/30/2015)... , July 30, 2015 ... "The Group") the regenerative medical devices company, announces ... the post-acute wound care market as Tissue Regenix ... DermaPure® under Medicare administrator, First Coast Service Options ... Florida , Puerto Rico ...
Breaking Medicine Technology:Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 2Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 3Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 4Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 2Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 3Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 4Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 5Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 6Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 7Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 8Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 9Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 10Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 11Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 12Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 13Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 14Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 15Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 16Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 17Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 18Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 19Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 20Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 21Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 22Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 23Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 24Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 25Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 26Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 27Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 28Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 29Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 30Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 31Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 32Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 33
... N.C., Sept. 3 The Medical Affairs function ... biopharmaceutical organization, with heavy responsibilities across areas such ... medical education. These areas must operate effectively for ... activities is one of the challenges facing the ...
... SHANGHAI, Sept. 3 /PRNewswire-Asia-FirstCall/ -- ... ... ... // Results are keyed by longUrl, so we need to grab the first one. for (var r ...
Cached Medicine Technology:Medical Affairs Report Outlines Resource Needs for Group Success 2China-Biotics Announces September 20 Investor Day Schedule 2China-Biotics Announces September 20 Investor Day Schedule 3China-Biotics Announces September 20 Investor Day Schedule 4China-Biotics Announces September 20 Investor Day Schedule 5China-Biotics Announces September 20 Investor Day Schedule 6China-Biotics Announces September 20 Investor Day Schedule 7
... enhances productivity in the laboratory with its ... methods clotting, chromogenic and immunological ... test results every time. With user ... random access, the CA-1500 will provide you ...
... Premier is our top-of-the-line device. ... attributes of the Qwik-Let® Elite, ... Lan-X feature. The Lan-X technology ... protection in the removal and ...
... the pain and hassle of testing. Unlike ... device is the only one with a ... testing, with less hassle and improved safety. ... and no side-to-side motion for less skin ...
... The new Finnpipette Focus from Thermo Labsystems ... uncompromising performance. Advanced features such as ... fine volume adjustment on microvolumes help to ... single channel pipettes. The new interchangeable handle ...
Medicine Products: