Navigation Links
Mass. General research could expand availability of hand, face transplants
Date:1/8/2014

Massachusetts General Hospital (MGH) investigators have made an important step towards greater availability of hand transplants, face transplants and other transplants involving multiple types of tissue. In their report in the American Journal of Transplantation, the team describes how a procedure developed at the MGH to induce immune tolerance to organ transplants also induces tolerance to a model limb transplant in miniature swine. Transplantation of donor bone marrow either several months before or simultaneous with the transplant allowed the animals to accept what are called vascularized composite allografts (VCAs) from immunologically mismatched donors.

"The need for lifelong immunosuppression to prevent graft rejection is the most important challenge in this type of procedure, since most potential VCA recipients are young and would face increased risks of infection, diabetes or kidney problems, and even some types of cancer over many years," says Curtis L. Cetrulo, Jr., MD, head of the Hand Transplantation Service in the MGH Division of Plastic and Reconstructive Surgery and senior author of the current report.

"Bringing immunologic tolerance to hand and face transplantation would result in a paradigm shift in the way we will be able to treat the horrific injuries our service members are sustaining in the current military conflicts in Iraq and Afghanistan, as well for the types of blast-injury extremity loss seen in the Boston Marathon bombing. Tolerance would give us a unique tool a real game changer with which to help these patients," he says.

Most frequently used to replace amputated hands and arms and to repair severe facial injuries, VCAs involve transplantation of muscle, bone, skin and nerves. While offering significant improvement in recipients' quality of life, the procedures are not required to preserve a patient's life, making the need for lifelong immunosuppression a disadvantage. The induction of
'/>"/>

Contact: Kristen Chadwick
kschadwick@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mass. Eye and Ear and HMS department of ophthalmology receives RPB Grant
2. Mass. Eye and Ear Researcher receives RPB Award
3. Mass. Eye and Ear, Joslin Diabetes announce collaboration in eye care
4. Mass. Launches Criminal Probe of Firm Linked to Meningitis Outbreak: Report
5. Mass. Eye and Ear researcher among winners of competition for Audacious ideas in research
6. Stryker Hip Replacement Lawsuit News: Mass. Woman Files First Known Federal Stryker ABG II Hip Lawsuit, Rottenstein Law Group Reports
7. 3 Mass. General researchers among recipients of Clinical Research Achievement awards
8. First corneal transplant with pre-loaded donor tissue performed at Mass. Eye and Ear
9. CDC, Mass. General study reveals that preventing malaria in travelers to West Africa reduces health costs
10. Young Mother Opens Home Helpers of Attleboro, Mass., to Address Need for Dependable In-Home Care
11. Surgeon General receives 2012 Distinguished Public Service Award from internal medicine physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Even the hot Texas sun won’t keep ... . The school had previously invested in a ... from APCPLAY, but recently asked for an innovative solution to ... Godley Elementary School chose a Rectangular Shade from APCPLAY as ... on their playground. The shade measures 24’W x 34’H ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Based in ... care to residents of Brazoria County and surrounding counties. ... the clinic is now accessible from Northbound Highway 288 ... a center where patients can get low-cost urgent care ... far from rare, finding places that can match the ...
(Date:7/10/2014)... 2014 Fatigue, lack of safety ... number of accidents in the workplace, according to ... articles highlight safety issues that contribute to the ... occur on the job annually, according to the ... explore "preventable workplace accidents." , Safety Issue: "Extended ...
(Date:7/10/2014)... 2014 According to a new ... Platforms (Land, Airborne, Naval), Application (Software Defined Radios, ... Geography (North America, Asia-Pacific, Europe, the Middle East ... by MarketsandMarkets, the market is estimated to be ... register a CAGR of 5.56% to reach $39.52 ...
(Date:7/10/2014)... 2014 Parker Waichman LLP, a ... of victims injured by defective medical devices, reports ... allegations that the woman’s hidden, aggressive leiomyosarcoma was ... used during a routine laparoscopic supracervical hysterectomy procedure. ... Medical Instruments Corporation over its Wolf Power Morcellator ...
Breaking Medicine News(10 mins):Health News:Cool Fun Under the Texas Sun: Godley Elementary School Purchases Shade Structure from APCPLAY© 2Health News:Prime Urgent Care Announces New Access to the Clinic, Available from Northbound Highway 288 2Health News:Safety Reboot Magazine Focuses on: Why Extended Hours is Dangerous in the Workplace; Why Custodial Work Can be Dangerous; and Improving Safety for Roofers 2Health News:Safety Reboot Magazine Focuses on: Why Extended Hours is Dangerous in the Workplace; Why Custodial Work Can be Dangerous; and Improving Safety for Roofers 3Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Portable Communication Systems Market Projected to Reach $39.52 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 2Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 3Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 4Health News:Couple Sues Over Alleged Cancer Risk Associated with use of a Power Morcellator During the Woman's Laparoscopic Fibroid Removal Procedure, Parker Waichman Comments 5
... , This release is available in Spanish ... have a powerful effect on formation of strong, healthy bones, ... hold true for humans. Jin-Ran Chen and his ... U.S. Department of Agriculture (USDA) at the Arkansas Children,s Nutrition ...
... tsunamis to war and genocide which wreak devastation on millions ... from the headlines. But how do policymakers, charities and medics ... influences their tactics and the style of humanitarian aid? ... London School of Hygiene & Tropical Medicine, with Boris Martin, ...
... In the 1983 movie "A Man with Two Brains," Steve Martin ... two brains inside his own skull as we all do, ... it comes to seeing the world around us, each of our ... working memory. Normally, it takes years or decades after a ...
... By Steven Reinberg HealthDay Reporter , MONDAY, ... increasingly popular, inflatable models, pose serious risks to young children, ... Children,s Hospital in Columbus, Ohio, detail the drowning deaths of ... a variety of above-ground pools, some large and deep, others ...
... substitutes used in low-calorie potato chips and other foods ... according to a study published by the American Psychological ... challenges the conventional wisdom that foods made with fat ... fat substitutes can interfere with the body,s ability to ...
... of medicine and community health sciences at Boston University ... Institute on Drug Abuse (NIDA) International Program 2011 Awards ... and investment in mentoring scientists in their pursuits in ... who is also chief of the Section of General ...
Cached Medicine News:Health News:Blueberries help lab rats build strong bones 2Health News:New book shines light on French versus British models of humanitarian aid 2Health News:Picower: 1 skull + 2 brains = 4 objects in mind 2Health News:Picower: 1 skull + 2 brains = 4 objects in mind 3Health News:Portable Pools Pose Drowning Risk for Young Kids 2Health News:Portable Pools Pose Drowning Risk for Young Kids 3Health News:Fat substitutes linked to weight gain 2Health News:BU'S Jeffrey H. Samet, M.D., selected as a 2011 NIDA International Program Awards of Excellence winner 2
(Date:7/10/2014)... 2014  Decision Resources Group finds that while ... specialists are willing to prescribe Durata,s Dalvance (dalbavancin) ... as OPAT, approximately two-thirds of the respondents reported ... hospital inpatients. However, our findings indicate that nearly ... on OPAT following hospital discharge, and most are ...
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... its store . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ... upgrade and policy support, China,s ... years, with total market size rising from 3.28 billion ...
(Date:1/15/2014)... Jan. 15, 2014  Novation, the leading health care supply ... IT value-added reseller (VAR) national contracts that expand its ... services at lower costs. These include manufacturer product and ... initiative assistance and ongoing IT consulting support. ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2
... April 9, 2008 Dutch biotechnology,company Crucell N.V., ... South,African Tuberculosis Vaccine Initiative (SATVI) present a progress ... tuberculosis vaccine study at the,biennial "Tuberculosis Vaccines for ... today. The study, conducted in Worcester, South,Africa and ...
... NEW YORK, April 9, 2008 Intra-Cellular ... its ongoing development,programs for ITI-007, the Company,s ... (DPPM), and ITI-722,a low-dose formulation of ITI-007, ... disorders, respectively. These new data demonstrate,ITI-007 has ...
Cached Medicine Technology:Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 2Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 3Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 4Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 5Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa 6Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722 2Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: