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Mass. General enters collaboration to develop new approach to capturing circulating tumor cells
Date:1/3/2011

Massachusetts General Hospital (MGH) has entered into a collaborative agreement with Veridex LLC to establish a center of excellence in research on circulating tumor cell (CTC) technologies. The overall goal of the agreement is to develop and commercialize novel technologies for capturing and characterizing CTCs, solid tumor cells found at extremely low levels in the bloodstream, which may offer a key to noninvasive characterization of cancer and potentially to early detection.

The collaboration will bring technology innovation experts from the MGH BioMicroElectroMechanical Systems (BioMEMS) Resource Center and molecular biologists and clinical researchers from the MGH Cancer Center together with research and development staff at Veridex, who have experience in clinical validation and regulatory clearance of novel technology, and at the Ortho Biotech Oncology R&D Unit of Johnson & Johnson Pharmaceutical Research, L.L.C., who have expertise in oncology therapeutics, biomarkers and companion diagnostics. The MGH team has already developed a microfluidic chip capable of capturing CTCs with a high rate of efficiency. However the technology now being developed with the companies is based on a new technological platform and will aim for even higher sensitivity, as well as suitability for broad applications and ready dissemination.

"This agreement is quite different from the usual academic-industrial agreement because we will be working together to bring new MGH-invented technology from its current, very early stage, through prototype and scale-up, to our ultimate goals of FDA approval and clinical adoption," says Mehmet Toner, PhD, director of the MGH BioMEMS Resource Center. "Our innovation team will be dedicated to developing this technology from its basic scientific principles all the way to initial prototyping within the biological research and clinical environments. Veridex has the knowledge required to translate early-stage technology int
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Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert

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