Navigation Links
Mass. General-based research center will investigate why immune system fails to control hepatitis C
Date:7/22/2009

A research consortium based at Massachusetts General Hospital (MGH) has been awarded $15 million from the National Institute of Allergy and Infectious Diseases to investigate how the hepatitis C virus (HCV) resists suppression and clearance by the immune system. The five-year grant will support a Cooperative Center for Translational Research in Human Immunology, which also will focus on how some individuals successfully recover from HCV while the infection becomes chronic in most of those infected, with a special emphasis on immunological events in the liver as the site of HCV replication.

"Hepatitis C is a major global health problem for which existing therapies are inadequate," says Raymond Chung, MD, director of Hepatology in the MGH Gastrointestinal Unit and co-director of the research center. "Improving our understanding of how and why the virus consistently evades immune system control should lead us to better ways of treating hepatitis C and possibly other chronic viral infections." Chung will lead a project to better define the role of the liver cells called hepatocytes in the innate and adaptive immune response to HCV infection.

Center co-director Paul Klenerman, PhD, of Oxford University will examine properties of the T cells that migrate to the liver in response to HCV infection. Additional principal investigators and project goals are:

  • Georg Lauer, MD, PhD, MGH Gastrointestinal Unit, and John Wherry, PhD, Wistar Institute investigate the functional capacity of CD4 and CD8 T cells within the liver in chronic HCV infection;
  • Todd Allen, PhD, Ragon Institute of MGH, MIT and Harvard, and Matthew Henn, PhD, Broad Institute of MIT and Harvard examine how selection pressure applied by T cells affects HCV evolution;
  • Gordon Freeman, PhD, Dana-Farber Cancer Institute develop a panel of reagents designed to modulate signaling in key immune cells;
  • Joseph Misdraji, MD, MGH Pathology create a library of liver c
    '/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Health Affairs Report On Mass. Mandatory Insurance Law Confirms: Strong Public Option Must Be Included in National Health Reform
2. Yankee Equity Solution ("YES") Launches $50 Million Fund for Mass.-Based Medtech Companies
3. Mass. General Hospital receives Gates Foundation grant to expand HIV controllers study
4. AIDS Action Asks Mass. Public Health Council to Forge a State AIDS Plan to Help Stop HIV/AIDS Here
5. Double-Digit Rate Increases Expected Under Mass. Mandatory Health Law; 5% Cap on Rate Hikes Proposed
6. Mass. Judge Denies Request by Breastfeeding Mother for More Break Time on Medical Licensing Exam
7. Cryo-Cell Announces Celle(SM) Research and Development Collaboration for Chronic Wound Healing Management
8. Zucker Hillside Researchers to Receive Large Federal Grant to Test for the Early Treatment of Schizophrenia
9. Major NIMH research project to test approaches to altering the course of schizophrenia
10. Clinical Research Safety and Ethical Standards in Developing World Up to U.S. Levels, Report Says
11. Amgen Scholars Discover Their Potential During Summer Science Research Program and National Symposium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2014)... 2014 Carol Fenster, a pioneering expert ... Quick Gluten-Free Recipes (Houghton Mifflin Harcourt, 2014)—that makes ... Fenster believes that cooking gluten-free food can be fun, ... lifestyle doesn’t leave much time for food preparation. ... me is how to shorten their time in the ...
(Date:8/26/2014)... Leelanau Peninsula, MI (PRWEB) August 27, 2014 ... Stompede event is a fabulous time to visit the ... providing a magnificent backdrop to wine tasting fun in ... 7, 2014. , Kicking off the festivities is an ... Saturday at Ciccone Vineyards in Suttons Bay. A unique ...
(Date:8/26/2014)... Atlanta, GA (PRWEB) August 27, 2014 ... Atlanta area location, Atlanta Hearing Associates has expanded its professional ... team is Dr. Stephanie Collins . Atlanta Hearing ... care professionals who display a passionate commitment to patient ... aid technology and hearing loss treatments. The practice has grown ...
(Date:8/26/2014)... NJ (PRWEB) August 27, 2014 ... Practitioners, announced today that Purdue Pharma L.P. will ... Thursday, September 4 at PAINWeek 2014, convening next ... course offerings, symposia and special sessions designed to ... opioids, as well as on the increasingly stringent ...
(Date:8/26/2014)... Recently, Top10BestSEOHosting.com, the famous SEO hosting ... suppliers and announced that Bluehost ( http://www.bluehost.com/track/seohosts ), ... hosting suppliers in 2014. , “Cheap hosting is ... money,” the development manager of op10BestSEOHosting.com states, “It ... supplier. Actually, these companies have outperformed their competitors ...
Breaking Medicine News(10 mins):Health News:Gluten-Free Expert Carol Fenster Announces New Cookbook for Quick Meals 2Health News:Gluten-Free Expert Carol Fenster Announces New Cookbook for Quick Meals 3Health News:Leelanau Peninsula’s Annual Harvest Stompede Offers One-of-a-Kind Walk or Run Through the Vineyards for Walkers, Runners and Wine Tasting Spectators Alike 2Health News:Leelanau Peninsula’s Annual Harvest Stompede Offers One-of-a-Kind Walk or Run Through the Vineyards for Walkers, Runners and Wine Tasting Spectators Alike 3Health News:Atlanta Hearing Associates Needs New Audiologists to Its Professional Staff 2Health News:Atlanta Hearing Associates Needs New Audiologists to Its Professional Staff 3Health News:Purdue Pharma L.P. to Sponsor Opioid Awareness Day at PAINWeek 2014 2Health News:SEO Hosting Review Site Top10BestSEOHosting.com Recommends Bluehost, JustHost and Arvixe To Worldwide People 2
... MIDDLEBURG HEIGHTS, Ohio, May 27 Allscripts announced ... selected Allscripts Professional(R) Electronic Health Record ... in multi-specialty practices across suburban Cleveland, Ohio. (Logo: ... care hospital and health center with its own ...
... A growing body of research was presented at ... American Academy of Physician Assistants (AAPA) 37th Annual Conference. ... educational bridge to consumers and they desire to know ... them to their patients. The symposium brought together scientific ...
... Americans currently take medication to manage their symptoms of ... untreated for ADHD - partially because the process can ... magazine aims to simplify things with expert explanations of ... more. NEW YORK, May 27 ADDitude ...
... Translational Genomics Research Institute (TGen) and the University of ... cancer, Stand Up to Cancer (SU2C) announced today. , ... B. Thompson, Director of the Abramson Cancer Center at ... which will lead a three-year investigation into new approaches ...
... 27 PRA International, a leading Clinical Research Organization, ... its Sao Paulo, Brazil office. Drug Safety Centers are ... unit. They are staffed with drug safety professionals who ... Reaction management. Furthermore, our drug safety personnel support ...
... 27 The Providence Service Corporation (Nasdaq: ... of the proxy statement filed last week by the ... believes that the Avalon Group,s proxy statement contains numerous ... is necessary for it to correct the public record ...
Cached Medicine News:Health News:Southwest General Health Center Selects Allscripts Web-Hosted Electronic Health Record 2Health News:Southwest General Health Center Selects Allscripts Web-Hosted Electronic Health Record 3Health News:Southwest General Health Center Selects Allscripts Web-Hosted Electronic Health Record 4Health News:Southwest General Health Center Selects Allscripts Web-Hosted Electronic Health Record 5Health News:Interest Surging in Probiotic Foods that Promote Health 2Health News:Interest Surging in Probiotic Foods that Promote Health 3Health News:Interest Surging in Probiotic Foods that Promote Health 4Health News:ADHD Treatment Guide: How to Safely, Effectively Use Medications and Non-Drug Therapies to Treat Attention Deficit Disorder 2Health News:$18 million awarded to TGen and University of Pennsylvania for pancreatic cancer research 2Health News:$18 million awarded to TGen and University of Pennsylvania for pancreatic cancer research 3Health News:$18 million awarded to TGen and University of Pennsylvania for pancreatic cancer research 4Health News:$18 million awarded to TGen and University of Pennsylvania for pancreatic cancer research 5Health News:PRA International Opens Additional Drug Safety Center in Sao Paulo, Brazil 2Health News:PRA International Opens Additional Drug Safety Center in Sao Paulo, Brazil 3Health News:Providence Service Corporation Rebuts False and Misleading Statements Contained in Proxy Statement Filed by the Avalon Group 2Health News:Providence Service Corporation Rebuts False and Misleading Statements Contained in Proxy Statement Filed by the Avalon Group 3
(Date:8/26/2014)... Del. , Aug. 26, 2014 Biomedical ... it has been named to the prestigious 2014 Inc. ... are honored to be included on this prestigious list ... said Chris Jacob , Biomedical Research Laboratories, CEO. ... and further serves to validate the hard work and ...
(Date:8/26/2014)... 2014 Acelleron Medical Products of North ... ., is expanding.  Acelleron, a home medical equipment provider, recently ... Acelleron Maternal Health & Wellness (MHW), to offer a wider ... range of resources for pregnant women and families. ... of maternal wellness. Vecchi, the former owner of Maternal Health ...
(Date:8/26/2014)... , Aug. 26, 2014  Sorrento Therapeutics, ... late-stage clinical oncology company developing new treatments for ... it has received funding to advance an immunotherapy ... treatment of IPF, which affects more than 100,000 ... lungs increases and patients gradually lose the ability ...
Breaking Medicine Technology:Biomedical Research Laboratories Named to Inc. 500 List of America's Fastest-Growing Companies 2Suzanne Vecchi Named Director of Newly Acquired Acelleron Maternal Health & Wellness 2Sorrento Awarded NIH Grant to Advance Immunotherapy Targeting Idiopathic Pulmonary Fibrosis (IPF) 2Sorrento Awarded NIH Grant to Advance Immunotherapy Targeting Idiopathic Pulmonary Fibrosis (IPF) 3
... ConvaTec, a world-leading developer and marketer of innovative medical ... appointment of several executives to new positions within the ... President, Intercontinental in a newly aligned region that will ... continue to be a strategic focus for growth for ...
... MAPLE GROVE, Minn., Feb. 7, 2011 Upsher-Smith Laboratories, Inc. ... vitamin, the newest addition to the Nexa™ Prenatal Vitamin ... Vitamin D3 (800 IU). Its advanced formulation offers more plant-based ... taken once a day.  Many experts recommend a DHA intake ...
Cached Medicine Technology:ConvaTec Announces New Appointments to Leadership Team 2Upsher-Smith Introduces Nexa™ Select With More Plant-Based DHA Than Any Other Once-Daily Single Gel Capsule Rx Prenatal Vitamin 2Upsher-Smith Introduces Nexa™ Select With More Plant-Based DHA Than Any Other Once-Daily Single Gel Capsule Rx Prenatal Vitamin 3Upsher-Smith Introduces Nexa™ Select With More Plant-Based DHA Than Any Other Once-Daily Single Gel Capsule Rx Prenatal Vitamin 4
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
Medicine Products: