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Mass. General Hospital to create registry for coronary optical coherence tomography
Date:3/25/2010

Massachusetts General Hospital (MGH), together with a coalition of 20 international sites in five countries, will create the world's largest registry of patients who have had optical coherence tomography (OCT) of the coronary arteries. OCT is an intravascular imaging technology that researchers hope will give doctors a better means to identify the dangerous vulnerable plaques that cause heart attacks and sudden cardiac death.

When a vulnerable plaque in the coronary artery ruptures, the result for the patient can be catastrophic. Ruptured plaques can block blood flow to the heart muscle, and cardiologists estimate they cause two-thirds to three-quarters of all fatal heart attacks. Standard imaging technologies are not able to identify the microscopic characteristics of vulnerable plaques.

Twenty sites in five countries Australia, China, Japan, Korea, and the United States will collect data from 3,000 patients who have had OCT of the coronary arteries during a cardiac catheterization procedure and follow them for five years. MGH researchers will gather the data in a central database. Researchers hope the data will help determine the efficacy of OCT in identifying vulnerable plaques in patients as well as its benefits as a follow-up procedure to stent placement.

"The Massachusetts General Hospital OCT Registry is the first time an international effort has formed to share information about OCT use in cardiac care," said Ik-Kyung Jang, MD, PhD, an interventional cardiologist at MGH and the principal investigator of the project. "In 2009, more than 10,000 OCT cases were performed. This collaborative effort will bring together this wealth of information and help us facilitate scientific advancement in the field of OCT."

The registry was launched during the first MGH OCT Registry Symposium held March 13, 2010, in Boston. The symposium, sponsored by LightLab Imaging, Inc., was the first gathering of OCT experts held in the United
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Contact: Jennifer Gundersen
jgundersen1@partners.org
617-724-6433
Massachusetts General Hospital
Source:Eurekalert

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