Navigation Links
Mass. General Hospital receives Gates Foundation grant to expand HIV controllers study
Date:3/4/2008

The Massachusetts General Hospital (MGH) has received a five-year, $20.5 million grant from the Bill & Melinda Gates Foundation to expand an international program investigating the biological factors underlying immune system control of HIV, the virus that causes AIDS. The grant provides support to the International HIV Controllers Study, which currently involves researchers from more than a dozen countries and has the overall goal of discovering information that can guide design of a vaccine to limit viral replication in HIV-infected individuals. A primary focus will be understanding genetic and immunological factors that have allowed a few individuals to control HIV naturally without the need for medications, some for more than 25 years.

The grant is part of the Collaboration for AIDS Vaccine Discovery, an international network of research consortia funded by the Gates Foundation to address priorities in the Global HIV Vaccine Enterprise scientific plan.

We believe that it is critical to understand how these individuals who are maintaining viral levels so low that transmission and disease progression should decrease markedly are keeping the virus in check and preventing it from causing disease, says Bruce Walker, MD, director of the Partners AIDS Research Center at MGH and principal investigator of the Gates Foundation grant. By recruiting enough of these individuals, we hope to identify the genetic basis for this viral control, using novel methods developed for the Human Genome Project. We believe this approach is all the more important given recent setbacks in HIV vaccine trials.

For more than 15 years it has been apparent that a small minority of HIV-positive people remained healthy despite many years of infection. As techniques for measuring viral levels in the bloodstream became more sensitive, it was possible to identify this group of viremic controllers, who can maintain viral loads below 2,000 copies/ml, and an even smaller group of aviremic or elite controllers, with viral loads less than 50 copies/ml. In 2006 Walker and his colleagues founded the HIV Controllers Study, with a $2.5 million grant from the Mark and Lisa Schwartz Foundation. Through national and international collaborations, they have already recruited nearly 1,000 controllers into the study.

With the new grant from the Gates Foundation, the team plans to expand the study group to 2,000 participants 1,000 elite controllers and 1,000 viremic controllers from around the world. The investigators will compare DNA from these individuals to genetic data from 3,000 people with progressive HIV infection, searching for genetic factors that may be associated with viremic control by sequencing 650,000 SNP (single nucleotide polymorphism) sites in each participants genome. The project will also use the latest technology to analyze which immune responses best suppress viral replication and investigate how the virus evolves to escape the immune system, additional information that can contribute to vaccine strategies.

Potential participants in the study are HIV-positive adults aged 18 to 75, not currently on anti-HIV medication, who have maintained viral loads less than 2,000 copies/ml for at least one year. Participation involves having a single blood sample taken, which can be done by participants local health care providers. Additional information about the study, including a list of participating institutions and more detailed instructions for enrolling and providing samples, is available at www.HIVcontrollers.org, by e-mailing elitecontrollerstudy@partners.org or calling 617 726-5536. All information gathered will be kept confidential.

Since other approaches to vaccine development have not been successful, uncovering how some humans are able to coexist with the virus without developing AIDS, in spite of not receiving any therapies, is critical, says Steven Deeks, MD, of the University of California at San Francisco, a major collaborator on the International HIV Controllers Study.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Related medicine news :

1. AIDS Action Asks Mass. Public Health Council to Forge a State AIDS Plan to Help Stop HIV/AIDS Here
2. Double-Digit Rate Increases Expected Under Mass. Mandatory Health Law; 5% Cap on Rate Hikes Proposed
3. Mass. Judge Denies Request by Breastfeeding Mother for More Break Time on Medical Licensing Exam
4. Accident Fund Names General Agency Company its 2007 Agency of the Year
5. TransUnion Addresses Ohio Attorney Generals Concerns Surrounding Non-Profit Tax-Exempt Status
6. Pennsylvania Attorney General Corbett Announces Multi-State Settlement With Caremark
7. AHIP Statement on New York Attorney Generals Announcement
8. SearchMedicas Second Quarterly Top Clinical Search Terms Report Reveals Top 25 Oncology, General Medicine and Psychiatry Search Terms Among Medical Professionals
9. General Atlantic and Hellman & Friedman Purchase HLTH Corporations Remaining Interest in Emdeon
10. HLTH Corporation Sells its Minority Interest in Emdeon Business Services to General Atlantic and Hellman & Friedman for $575 Million
11. Former Navy Surgeon General Is Among Three New Accomplished TriWest Advisory Board Members
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Using the power of ... a simple online checklist. Over a period of just 24 months, thousands of individuals ... an online checklist called T.A.D. , “The internet is not getting quieter. In fact ...
(Date:2/22/2017)... ... February 22, 2017 , ... ANGLESTRONG , the new recovery ... available on the App Store and Google Play . Florida-based Sober ... addiction and recovery industry, partnered with Angle to build ANGLESTRONG. The new recovery management ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... related to spine practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., as a ... of a small number of neurosurgeons in Michigan performing minimally invasive back surgery ...
(Date:2/22/2017)... PA (PRWEB) , ... February 22, 2017 , ... A ... some people seem to derive a heart-protective benefit from eating soy foods, while others ... , Japanese men who are able to produce equol—a substance made by some types ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... hearing and 72 percent of those report that family members or friends have ... think they suffer from hearing loss wear hearing aids. One reason, suggested by ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 2017  Bioness, Inc., the leading provider of cutting ... series of successful StimRouter Neuromodulation System implantations in ... (Nijmegen, Netherlands ), South ... ), and Kliniek Park Leopold Chirec ( Brussels, ... plans to further support clinicians across the continent who ...
(Date:2/22/2017)... Colo. , Feb. 22, 2017  Aytu BioScience, ... global commercialization of novel products in the field of ... team to up to 42 account managers from 35 ... The sales force expansion is being ... prescriptions and revenues, an indication of increasing acceptance of ...
(Date:2/22/2017)... -- According to a new market research report "Process Analytical ... Services (Analyzers, Probes & Sensors), End - User (Pharmaceutical Manufacturers, CRO & ... is poised to reach USD 3.30 Billion by 2021 from USD 1.77 ... Continue Reading ... ...
Breaking Medicine Technology: