Navigation Links
Marker of Ewing sarcoma: Potential new drug target?
Date:2/8/2010

Ewing sarcoma (EWS) is a bone tumor of unknown cellular origin that affects children and young adults. The protein CD99 is highly expressed in most cases of EWS, but its function in the disease is unknown. Now, Katia Scotlandi and colleagues, at SSN Emilia Romagna Istituto Ortopedico Rizzoli IRCCS, Bologna, Italy, have identified a crucial role for CD99 in the development of EWS and suggest that targeting CD99 or its downstream molecular pathway may be a new therapeutic approach for EWS.

In the study, decreasing CD99 expression in human EWS cell lines reduced their ability to form tumors xenografted into mice. In vitro, it increased expression of H-neurofilament, a marker of neuronal differentiation. Consistent with this, an inverse correlation between CD99 expression and H-neurofilament expression, neural differentiation, and oncogenic transformation was observed in patient-derived EWS cells. The authors therefore conclude that CD99 prevents neural differentiation and suggest that blocking it might provide a new approach to treating EWS.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Michael J. Fox Foundation Awards $2.8 Million to Drive Development of Parkinsons Disease Biomarker Pipeline
2. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
3. Biomarker could help doctors tailor treatment for rheumatoid arthritis
4. Genetic Marker for Aggressive Prostate Cancer Found
5. TGen analysis identifies biomarkers for diabetic kidney failure
6. Positive Data from Arena Pharmaceuticals Pivotal BLOOM Trial Demonstrate that Lorcaserin Significantly Improved Markers of Cardiovascular Risk and Glycemic Parameters and was not Associated with Depression or Suicidal Ideation
7. Orexigen(R) Therapeutics Presents New Data Showing Weight Loss with Contrave Significantly Improves Important Markers of Cardiometabolic Risk
8. Workshop tackles challenges in biomarker and drug development
9. Scientists identify specific markers that trigger aggressiveness of liver cancer
10. Biomedical Research Centre searches for immunological biomarkers
11. News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Our ... to overwork even the sharpest brain. , Power On, a mental performance enhancer ... over clocking the brain. Each capsule contains Cognizin® Citicoline, a branded form of ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... The ... to the thousands of individuals who have recently fallen victim to America’s opioid epidemic. ... in Orange County, California, where they are free from the shame, stigma, and ...
(Date:2/22/2017)... ... February 22, 2017 , ... South Bend’s Lunkerville, the award-winning TV series that ... On The Water (HOW), a non-profit organization dedicated to helping military veterans relax, rehabilitate, ... ‘Mike D’ traveling to Lake Denmark, New Jersey, to fish with war veteran Justin ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... chronic conditions reported skipping doses or not filling a prescription because they could ... rates of cost-related problems getting medications were 30-60%*. At the same ...
(Date:2/22/2017)... ... ... Sideline Products participated in the World Horse Expo held in Timonium, MD ... production crew. Tom Seay’s program “Best of America by Horseback” is broadcasted on ... be featured on April 6, 2017. After the broadcast, the clip will be posted ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... The Senior Care Pharmacy Coalition (SCPC) today ... of Representatives that will curtail the ability of drug ... extracting retroactive direct and indirect remuneration (DIR) fees in ... the Medicare program. S. 413, introduced by ... Jon Tester (D-MT), and House companion bill, H.R. ...
(Date:2/22/2017)... 2017 Henry Schein Medical today announced ... with Rijuven, which develops innovative digital medical devices, ... practitioners. CardioSleeve is a stethoscope ... sound signals, transmits real-time data to any smartphone ... to help physicians provide diagnostic interpretation of a ...
(Date:2/22/2017)... 2017  Allergan plc (NYSE: AGN), a leading ... Gold sponsor of the Alzheimer,s Foundation of America,s ... tour commemorates AFA,s15 years of educating individuals about ... The tour will include AFA,s free Concepts in ... of the AFA Quilt to Remember. ...
Breaking Medicine Technology: