Navigation Links
Marker distinguishes more-aggressive from less-aggressive forms of chronic leukemia
Date:6/12/2012

  • People newly diagnosed with chronic leukemia must often wait to learn if they have a faster- or slower-progressing form of the disease.
  • This study identified a molecular marker that quickly helps to distinguish which form a patients has.
  • The findings could enable patients with aggressive disease to start treatment sooner.

COLUMBUS, Ohio Researchers have identified a prognostic marker in the most common form of chronic leukemia that can help to distinguish which patients should start treatment quickly from those who can safely delay treatment, perhaps for years.

The study, led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James), focused on chronic lymphocytic leukemia (CLL), a malignancy expected to occur in 16,000 Americans this year and cause 4,600 deaths.

The researchers examined a gene called ZAP-70 in CLL cells for a chemical change called methylation. They found that when the gene in leukemia cells is methylated, patients are likely to have the slow-progressing form of CLL, and when the ZAP-70 gene is unmethylated, patients are likely to have aggressive disease and should consider beginning treatment immediately.

Currently, doctors must simply observe newly diagnosed patients to determine which type of CLL they have. This can delay the start of treatment in patients with aggressive disease, or it can lead to treating patients who don't yet require it.

The findings are published in the Journal of Clinical Oncology.

"This study demonstrates that ZAP-70 methylation status is a highly predictive, reproducible biomarker of poor prognosis in this disease, and a clinically useful prognostic test for CLL," says principal investigator Dr. John Byrd, a CLL specialist and professor of Medicine, of Medicinal Chemistry and of Veterinary Biosciences at the OSUCCC James.

Currently, the presence of mutations in a gene called IGVH (immunoglobulin heavy chain variable region gene), and the amount of protein produced by the ZAP-70 gene in CLL cells are sometimes used to predict prognosis and response to treatment in people with this disease, "but these assays are expensive and difficult to perform," says coauthor and researcher Dr. David Lucas, research assistant professor and CLL specialist at the OSUCCC James.

"In all cells, some areas of DNA undergo methylation, which controls how that DNA is used," Lucas says. "In cancer cells, the pattern of DNA methylation is often different from that of healthy cells, and this influences how much protein is produced by ZAP-70 and other genes."

Because the protein produced by the ZAP-70 gene is often present at different levels in leukemia cells, Byrd, Lucas and their colleagues hypothesized that changes in ZAP-70 methylation status could explain decreases in the gene's expression and a more favorable clinical outcome.

The researchers examined CLL cells from 247 patients obtained through four independent clinical trials. Project co-leader, Dr. Christoph Plass, of the Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center in Heidelberg, Germany, used a new mass spectroscopy-based technique to assess DNA methylation of the ZAP-70 regulatory region.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
2. The REMARK checklist explained: How to use guidelines on reporting tumor marker prognostic studies
3. Novel biomarkers reveal evidence of radiation exposure
4. Genetic marker may predict smoking quantity in African Americans
5. Biomarker predicts response to cancer treatment
6. Scientists discover marker to identify, attack breast cancer stem cells
7. New biomarker test predicts arthritis at much earlier stage, MU researchers say
8. A marker in the lining of the lungs could be useful diagnostic technique for lung cancer screening
9. Early biomarker for pancreatic cancer identified
10. A microRNA prognostic marker identified in acute leukemia
11. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2016)... ... May 30, 2016 , ... Another ER facility operated by First Choice ... Legacy Drive, Plano, TX and is open 24 hours daily. , First Choice Emergency ... medical open house. The Jasper High School band entertained attendees and accepted First Choice ...
(Date:5/29/2016)... ... May 29, 2016 , ... "With 30 unique self-animating web themed intros and ... of their project," said Christina Austin - CEO of Pixel Film Studios. , ... for use in Final Cut Pro X. Pixel Film Studios’ minimalistic titles allow users ...
(Date:5/28/2016)... ... 2016 , ... May 26, 2016- In search of the K. Warriors, Shaolin ... of “K Warriors” on June 4, 2016 at Ashbury Hotel and Suites 600 West ... and hosted by Shaolin Institute and sanctioned by KSF (Kungfu Sanda Federation), This is ...
(Date:5/27/2016)... ... May 27, 2016 , ... More than a third of American adults are ... bariatric surgery has received increased attention in recent years, as an article ... to weight loss, most people are familiar with the basic requirements of maintaining a ...
(Date:5/27/2016)... ... , ... W.S. Badger Co. Inc ., the maker of certified organic ... one of the best small businesses for new dads by Fatherly, the digital lifestyle ... providing progressive benefits to new parents on the organization’s 2016 Best Places to ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... PUNE, India , May 30, 2016 /PRNewswire/ ... Pipeline Review, H1 2016" market research report with ... Colitis, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ... press releases. It also reviews key players involved ...
(Date:5/27/2016)... -- A new study highlights the necessity of health literacy within the technology advancement of ... of Radiology , a majority of oncology patients undergo imaging screenings without understanding the ... ... ... Medical Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... 27, 2016 According to the ... is driving ambulatory blood pressure monitoring system market growth. ... their ability to respond to different pressure rates, leading ... lead to various cardiovascular disorders such as heart failure, ... diseases are growing in prevalence each year. WHO estimates ...
Breaking Medicine Technology: