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Marinus Pharmaceuticals, Inc. Announces Positive Results of its Phase 2 Clinical Trial of Ganaxolone as Adjunctive Therapy in Adults With Partial Onset Seizures
Date:3/2/2009

rse events were CNS-related and were mild to moderate in severity. Common adverse events experienced by more than 5 percent of subjects included dizziness, fatigue, somnolence, headache, abnormal coordination, falls, nasopharyngitis (an inflammation of the nasal passages) and convulsion. No deaths were reported in this study.

All patients completing the double blind portion were eligible to enter an open label extension trial, with 95 percent of patients electing to continue therapy. Based on these results, Marinus is planning a dose-ranging Phase 2b program with ganaxolone.

About Ganaxolone

Ganaxolone is a synthetic neurosteroid and a derivative of the naturally occurring neuromodulator, allopregnanolone. It is being investigated as a first in class treatment for epilepsy. Ganaxolone has been administered to more than 950 healthy adult volunteers and patients in more than 35 Phase 1 and Phase 2 studies. Early epilepsy studies involved more than 100 patients and generated data supportive of the efficacy and safety of ganaxolone in the treatment of both children and adults suffering from refractory epilepsy (patients who continue to have seizures despite taking multiple anticonvulsant drugs).

Marinus has successfully developed several proprietary and novel patented formulations of ganaxolone.

About Marinus Pharmaceuticals

Marinus is a specialty pharmaceutical company dedicated to the reformulation, development, and commercialization of novel drugs to treat serious neurological, psychiatric, and pain disorders. Marinus is located in Branford, Connecticut. Its investors include Domain Associates, Canaan Partners, Sofinnova Ventures and Foundation Medical Partners. For additional information, please visit the company's Web site at www.marinuspharma.com.

About Epilepsy

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SOURCE Marinus Pharmaceuticals, Inc.
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