Navigation Links
Marijuana ineffective as an Alzheimer's treatment: UBC-Vancouver Coastal Health research
Date:2/8/2010

The benefits of marijuana in tempering or reversing the effects of Alzheimer's disease have been challenged in a new study by researchers at the University of British Columbia and Vancouver Coastal Health Research Institute.

The findings, published in the current issue of the journal Current Alzheimer Research, could lower expectations about the benefits of medical marijuana in combating various cognitive diseases and help redirect future research to more promising therapeutics.

Previous studies using animal models showed that HU210, a synthetic form of the compounds found in marijuana, reduced the toxicity of plaques and promoted the growth of new neurons. Those studies used rats carrying amyloid protein, the toxin that forms plaques in the brains of Alzheimer's victims.

The new study, led by Dr. Weihong Song, Canada Research Chair in Alzheimer's Disease and a professor of psychiatry in the UBC Faculty of Medicine, was the first to test those findings using mice carrying human genetic mutations that cause Alzheimer's disease widely considered to be a more accurate model for the disease in humans.

"As scientists, we begin every study hoping to be able to confirm beneficial effects of potential therapies, and we hoped to confirm this for the use of medical marijuana in treating Alzheimer's disease," says Song, a member of the Brain Research Centre at UBC and VCH Research Institute and Director of Townsend Family Laboratories at UBC.

"But we didn't see any benefit at all. Instead, our study pointed to some detrimental effects."

Over a period of several weeks, some of the Alzheimer's-afflicted mice were given varying doses of HU210 also known as cannabinoids which is 100 to 800 times more potent than the marijuana compounds. Their memory was then tested.

The mice treated with HU210 did no better than untreated mice, with those given low doses of HU210 performing the worst. The researchers also found that HU210-treated mice had just as much plaque formation and the same density of neurons as the control group. The group given higher doses actually had fewer brain cells.

"Our study shows that HU210 has no biological or behavioural effect on the established Alzheimer's disease model," says Song, the Jack Brown and Family Professor and Chair in Alzheimer's Disease. "More studies should be done before we place much hope in marijuana's benefits for Alzheimer's patients."


'/>"/>

Contact: Hilary Thomson
hilary.thomson@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related medicine news :

1. 215 Agenda Medical Marijuana Collective Located in Lake Forest, CA, has Donated $1,500 to Friends of the El Toro Library
2. Medical Marijuana Super Store Opens in East Oakland
3. Marijuana Compounds Could Beat Back Brain Cancer
4. Marijuana Munchies May Be Rooted in Biology
5. Teen Marijuana Use Might Have Lasting Effects on Mood, Anxiety
6. Pot and pop: New research finds stronger link between music and marijuana use among teens
7. Marijuana, Alcohol Addiction May Share Genes
8. Marijuana Use No Longer Dropping Among U.S. Teens
9. Medithrive Voted #1 Medicinal Marijuana Dispensary in Bay Area
10. Review Finds Marijuana May Help MS Patients
11. Parental Monitoring Can Curb Teen Marijuana Use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... 2017 , ... Leading pediatric oncology experts at Children’s National Health System ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of ...
(Date:10/12/2017)... RAPIDS, Mich. (PRWEB) , ... October 12, 2017 ... ... Wellness, has been named one of Michigan’s 2017 Best and Brightest in Wellness® ... and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... University of California Berkeley, and other leading institutions in announcing the launch of ... institutions to change the way animals are raised for food. , Founding members ...
(Date:10/12/2017)... ... October 12, 2017 , ... Nvision Biomedical Technologies ... with the addition of industry sales leader, Thomas (Tom) Slott, as Senior Vice ... distribution and sales network, direct the efforts of the surgical sales teams, manage ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/12/2017)... 12, 2017   EcoVadis , the leading platform for environmental, social ... annual edition of its Global CSR Risk and Performance Index. The report ... based on Scorecard Ratings that analyzed nearly 800,000 data points across the ... ... ...
Breaking Medicine Technology: