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Marijuana dependence alters the brain's response to drug paraphernalia
Date:7/15/2014

New research from The University of Texas at Dallas demonstrates that drug paraphernalia triggers the reward areas of the brain differently in dependent and non-dependent marijuana users.

The study, published July 1 in Drug and Alcohol Dependence, demonstrated that different areas of the brain activated when dependent and non-dependent users were exposed to drug-related cues.

The 2012 National Survey on Drug Use and Health shows marijuana is the most widely used illicit drug in the United States. According to a 2013 survey from the Pew Research Center, 48 percent of Americans ages 18 and older have tried marijuana. The National Institute on Drug Abuse states that 9 percent of daily users will become dependent on marijuana.

"We know that people have a hard time staying abstinent because seeing cues for the drug use triggers this intense desire to seek out the drugs," said Dr. Francesca Filbey, lead author of the study and professor at the Center for BrainHealth in the School of Behavioral and Brain Sciences. "That's a clinically validated phenomenon and behavioral studies have also shown this to be the case. What we didn't know was what was driving those effects in the brain."

To find this effect, Filbey and colleagues conducted brain-imaging scans, called functional magnetic resonance imaging (fMRI), on 71 participants who regularly used marijuana. Just more than half of those were classified as dependent users. While being scanned, the participants were given either a used marijuana pipe or a pencil of approximately the same size that they could see and feel.

A comparison of the images revealed that the nucleus accumbens, the reward region in the brain, was activated in all users in response to the pipe. However, the strengths of the connections with other areas differed between dependent and non-dependent users.

"We found that the reward network is actually being driven by other areas unrelated
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Contact: Ben Porter
ben.porter@utdallas.edu
972-883-2193
University of Texas at Dallas
Source:Eurekalert  

Page: 1 2

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