Navigation Links
March of Dimes awards $250,000 prize to leaders in understanding embryonic development
Date:5/4/2008

HONOLULU, MAY 5, 2008 Two scientists who helped explain how embryos develop and form limbs, the brain, and other organs have been chosen to receive the 2008 March of Dimes Prize in Developmental Biology.

Philip A. Beachy, PhD, and Clifford J. Tabin, PhD will share the 2008 March of Dimes Prize for their pioneering work that has expanded our understanding of how hedgehog genes and their protein signals guide the formation of the brain, limbs, spinal cord, axial skeleton and other organs during embryonic and fetal development. Their work has become a model for how communication between cells directs the course of animal development.

The March of Dimes Prize is a $250,000 cash award and a silver medal in the design of the Roosevelt dime, in honor of President Franklin Delano Roosevelt, who founded the March of Dimes. The Prize will be awarded to Dr. Beachy and Dr. Tabin at a gala black tie dinner and ceremony at the Moana Surfrider here.

Hedgehog genes have a wide-ranging role in mammalian development, said Michael Katz, MD, senior vice president for Research and Global Programs at the March of Dimes. Dr. Beachys and Dr. Tabins studies have provided crucial insight into how some birth defects and some cancers develop. The results of their research have expanded our knowledge of how these genes control the division of adult stem cells.

The genes are named hedgehog because when mutations that caused the gene to lose function first were identified (in fruit flies), they gave the embryos a prickly appearance. The genes protein signals play a crucial role in how cells organize themselves in the body and form specific organs.

For example, these signals are involved in why the heart is located on the left and not the right side of the body; why we have two eyes and nostrils instead of one; why the thumb is different from the little finger; and why different types of neurons form in specific locations within the spinal cord.

Dr. Beachy is the Ernest and Amelia Gallo Professor in the Department of Developmental Biology and in the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University School of Medicine in Stanford, Calif. His research elucidated the processing and structure of the hedgehog protein signal and its attachment to cholesterol, and led to an understanding of malformations caused by deficiencies in hedgehog signaling, including brain and facial malformations associated with holoprosencephaly (when the brain fails to completely develop and divide). His work also produced important insights into the role and treatment of inappropriate hedgehog pathway activity in cancer.

Dr. Tabin is the George Jacob and Jacqueline Hazel Leder Professor and chair of the Department of Genetics at Harvard Medical School in Massachusetts. His research explains how anatomical form and organization emerge during the embryonic development of an organism, and how errors in this process lead to birth defects. His work with the Sonic hedgehog gene led to the first identification of genes differentially expressed on the left and right sides of the early embryo, a major breakthrough in understanding left-right asymmetry; as well as to an understanding of how bones muscles and tendons are placed in their proper orientation in the forming limbs.

The March of Dimes Prize in Developmental Biology has been awarded annually since 1996 to investigators whose research has profoundly advanced the science that underlies the understanding of birth defects. The March of Dimes Foundation created the Prize as a tribute to Dr. Jonas Salk, who received Foundation support for his work to create a polio vaccine.

Also on May 5, Dr. Beachy and Dr. Tabin will deliver the Thirteenth Annual March of Dimes Prize Lectures at the Hawaii Convention Center during the 2008 Annual Meeting of the Pediatric Academic Societies.


'/>"/>

Contact: Elizabeth Lynch
elynch@marchofdimes.com
914-997-4286
March of Dimes Foundation
Source:Eurekalert

Related medicine news :

1. Top Music Artists Contribute to New CD for Moms to Benefit March of Dimes
2. Young Innovations, Inc. Announces Results for the Quarter Ended March 31, 2008
3. March for Babies a Success With Help From Equal Health
4. Eli Manning Leads March for Babies in Manhattan
5. Northwest Songwriter Dean Backholm Featured on National March of Dimes CD
6. Longs Reports Preliminary March Retail Drug Store Sales
7. Merit Medical Systems Announces Earnings Release Date/Time and Conference Call Information for the First Quarter Ended March 31, 2008
8. BioForm Medical to Announce Financial Results For Quarter Ended March 31, 2008, Third Quarter of Fiscal 2008, and Host Conference Call and Webcast on May 1, 2008
9. National Council on Disability Monthly Bulletin for March 2008
10. Humboldt Storage & Moving to Partner with March for Babies
11. March For Babies Has Celebrity Support -- Now It Needs Yours
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania Athletic ... Erie Bayfront and Erie Convention Center on June 8-10. The weekend consisted ... quiz bowl, award and scholarship presentations, and professional networking. , On Friday ...
(Date:6/24/2017)... ... June 24, 2017 , ... Doorknobs are for convenience, deadbolts are for ... a guard dog or having an alarm system installed. But unless there is a ... Yair Frenkel, owner of TX Premier Locksmith in Killeen, TX says: “In the majority ...
(Date:6/23/2017)... Long Beach, CA (PRWEB) , ... June 23, 2017 , ... ... (ANRF) has earned its ninth consecutive four-star rating from premier online charity evaluator, Charity ... ANRF in the top 1% of all charities reviewed by Charity Navigator and earns ...
(Date:6/23/2017)... Va. (PRWEB) , ... June 23, 2017 , ... The ... the president's nominee for deputy secretary of Veterans Affairs, retired Marine Col. Thomas G. ... Veterans Affairs. , Bowman brings an intimacy with the issues and challenges ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference when it ... it, and some people don't like it at all. FindaTopDoc took a look at ... Erotic literature can give readers a taste of their deepest, darkest fantasies and has ...
Breaking Medicine News(10 mins):
(Date:6/11/2017)... June 10, 2017  Eli Lilly and Company (NYSE: ... Phase 3 studies of galcanezumab, an investigational treatment for ... data on several key secondary endpoints for galcanezumab compared ... these studies (EVOLVE-1, EVOLVE-2 and REGAIN) will be presented ... meeting in Boston . ...
(Date:6/9/2017)... June 9, 2017 AirXpanders, Inc. (ASX: AXP) ... the design, manufacture, sale and distribution of the AeroForm® ... progress of its commercial roll-out in the ... more than one hundred (100) medical institutions and health ... offers a needle-free alternative for women who choose reconstructive ...
(Date:6/8/2017)...  Less than a month ago, amateur hackers executed ... including hospital networks, in over 150 countries. ... largest online extortion attempts ever recorded. With the increasing ... imperative that providers understand where the risks lie, and ... and many other very real cyber threats.  ...
Breaking Medicine Technology: