Navigation Links
Mapping of protein inhibitors facilitates development of tailor-made anticancer agents
Date:2/21/2012

A team of researchers at Karolinska Institutet in Sweden has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. This map may explain the mechanism behind putative side effects of the so-called PARP inhibitors, and can play an important role in the development of novel tailor-made cancer drugs. The study is presented in the journal Nature Biotechnology, and will hopefully contribute to new cancer therapies with fewer detrimental side effects.

PARP1 is a protein with enzymatic activity that governs repair of DNA damage in our cells. In the past decade, PARP1 has been in the focus for a large number of industrial drug development projects, primarily targeting breast and ovarian cancers. More than 50 clinical studies have been initiated around the world.

In the current study, the researchers at Karolinska Institutet have tested the effects of small drug-like molecules inhibitors on PARP1 and other enzymes of the same class. The effects of 180 substances on 13 different human PARP enzymes were studied. Many of the drugs that are currently being tested in clinical studies were part of the survey.

"Our results give us a map over the effects of a number of known but also less well characterized drug-like compounds on different PARP enzymes", says Herwig Schler, who headed the study at the Department of Medical Biochemistry and Biophysics. "Studying the cross-reactivity of less well characterized compounds on different PARP enzymes is especially interesting, since it can give clues to the interpretation of clinical side effects."

The chemical interaction map was complemented with high-resolution structural information, showing at atomic detail how inhibitors bind to these PARP enzymes. Together, the results give unique insights into specificity and cross-reactivity of PARP inhibitors. This in turn will be an important hallmark toward development of selective PARP in
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related medicine news :

1. CSHL team introduces automated imaging to greatly speed whole-brain mapping efforts
2. Fast new method for mapping blood vessels may aid cancer research
3. Blood vessel mapping reveals 4 new ZIP codes
4. Gene Mapping Reveals Clues to Bedbugs Pesticide Resistance
5. Roadmap published for dynamic mapping of estrogen signaling in breast cancer
6. Mapping faculty social networks helps female faculty move ahead at NJIT
7. Mapping a brain atlas
8. ELLKAY Introduces Revolutionary Live Insurance Mapping Solution for Diagnostic Laboratories
9. A single protein helps the body keep watch over the Epstein-Barr virus
10. CD97 gene expression and function correlate with WT1 protein expression and glioma invasiveness
11. Protein structures give disease clues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Cooking and warming equipment ... of 5. This score reflects slightly positive negotiation conditions ... specialization, low switching costs and a low level of ... low availability of substitutes for cooking and warming equipment ... and aluminum, key inputs in the production process of ...
(Date:12/26/2014)... (PRWEB) December 26, 2014 “Many people ... with personal injury claim issues and phone calls with ... released an article featuring their free eBook on ... helpful eBook on pedestrian and bicycle auto accident claims ... is fully capable of professionally handling their case while ...
(Date:12/26/2014)... AZ (PRWEB) December 26, 2014 ... source for the best in heating, cooling and ... for 24 hour emergency services in 2014 with ... alike know that Arizona is known for its ... company that understands the intricacies and details of ...
(Date:12/25/2014)... 26, 2014 The report “Nintedanib ... 2023” focuses on the current treatment landscape, unmet ... colorectal cancer market. Stivarga is a drug which ... rectal cancer. Boehringer Ingelheim is developing nintedanib (BIBF-1120), ... of refractory CRC in the US, Europe, and ...
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of ... its new selection of black one-shoulder cocktail dresses . ... they are available at discounted prices, up to 70% off. ... last for three weeks only. You know, we have thousands ... interested in our new items can visit our website for ...
Breaking Medicine News(10 mins):Health News:Cooking & Warming Equipment Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Cooking & Warming Equipment Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2
... , ... it,s time to shake off winter doldrums, lace up the running shoes and get moving. While ... System,s Geriatric Research, Education, and Clinical Center (GRECC) say that keeping active all year is the ... ...
... ... fertility in women and men, as well as infertility diagnosis, treatment and options. , ... (PRWEB) March 9, 2010 -- A ... are surprised when their attempts at conceiving aren,t successful within the first few months. , ...
... ... ... ... ...
... ... ... ... ...
... performing a hysterectomy is common practice to prevent the ... performed in 55 percent of all US women having ... article in the March/April issue of t Philadelphia, PA, ... oophorectomy) while performing a hysterectomy is common practice to ...
... , ... special pricing on cognitive skills testing in March, , ... Denver, CO (Vocus) March 9, 2010 -- Do you know the ... Month) and the local LearningRx cognitive skills’ experts are offering free tips, activities, ...
Cached Medicine News:Health News:The VA Maryland Health Care System Offers Tips for Senior Citizens and Older Adults to Spring into Shape 2Health News:The VA Maryland Health Care System Offers Tips for Senior Citizens and Older Adults to Spring into Shape 3Health News:The VA Maryland Health Care System Offers Tips for Senior Citizens and Older Adults to Spring into Shape 4Health News:The VA Maryland Health Care System Offers Tips for Senior Citizens and Older Adults to Spring into Shape 5Health News:'Get Pregnant' Aims To Help Couples Conceive Naturally, Faster 2Health News:2010 Recipient of Minority Scholar Award Will Conduct Clinical Research on Leukemia 2Health News:2010 Recipient of Minority Scholar Award Will Conduct Clinical Research on Leukemia 3Health News:2010 Recipient of Minority Scholar Award Will Conduct Clinical Research on Leukemia 4Health News:2010 Recipient of Minority Scholar Award Will Conduct Clinical Research on Leukemia 5Health News:U.S. Senator Kit Bond Receives 2010 AOA Health Care Leadership Award 2Health News:U.S. Senator Kit Bond Receives 2010 AOA Health Care Leadership Award 3Health News:U.S. Senator Kit Bond Receives 2010 AOA Health Care Leadership Award 4Health News:U.S. Senator Kit Bond Receives 2010 AOA Health Care Leadership Award 5Health News:New study questions benefits of elective removal of ovaries during hysterectomy 2Health News:Free Brain IQ Quiz, Activities for Home “Brain-Boosting” and Seminar Offered from LearningRX Denver during National Brain Awareness Month 2Health News:Free Brain IQ Quiz, Activities for Home “Brain-Boosting” and Seminar Offered from LearningRX Denver during National Brain Awareness Month 3Health News:Free Brain IQ Quiz, Activities for Home “Brain-Boosting” and Seminar Offered from LearningRX Denver during National Brain Awareness Month 4
(Date:12/24/2014)... -- ResMed (NYSE: RMD ) today announced its ... device manufacturer BMC Medical Co., Ltd. The ... below infringe ResMed,s patents, and entered an order prohibiting BMC ... the United States : , iVolve nasal ... nasal pillows mask , iVolve full face mask ...
(Date:12/24/2014)... , Dec. 23, 2014   Assurex Health, ... support to healthcare providers for behavioral health and ... secured $30 million in equity financing from new ... Drosos , President and Chief Executive Officer. ... and development of Assurex Health,s GeneSight ® ...
(Date:12/24/2014)... China , Dec. 23, 2014 ... pharmaceutical company that specializes in patented biopharmaceutical, modernized ... pharmaceutical ingredients (API) today announced that the Company ... its Good Manufacturing Practice (GMP) certificate of TPI,s ... Drug Administration,s (CFDA). The public notice period is ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59%... -- BEIJING, Aug. 16 /PRNewswire-Asia-FirstCall/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... { var s = ,; var first_result; // Results are keyed by longUrl, so we need to ...
... Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets -- LAIYANG, China, Aug. ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... var shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // ...
Cached Medicine Technology:Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 2Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 3Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 4Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 5Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 6Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 7Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 8Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 9Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 10Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 11Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 12Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 2Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 3Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 4Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 5Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 6Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 7
... creation of a vascular access, a correctly ... the utmost importance in many vascular procedures. ... seeking a high-precision tunneling instrument. The unique ... twisting or kinking for more accurate graft ...
... GORE-TEX Stretch Vascular Grafts have ... demanding vascular procedures. Recognized for exceptional ... the endorsement of renowned surgeons worldwide. ... dilatation and the spread of infection, ...
... vascular surgery, and the accompanying need for ... of graft be developed. Grafts must not ... also available in varying sizes and configurations ... has long been the prosthetic of choice ...
... newest vascular graft offering from W. L. ... surgical products for more than two decades, ... compression problems that can lead to ... of the benefits of a ring graft ...
Medicine Products: