Navigation Links
Mapping of prostate cancer genes opens the door to new treatments
Date:5/19/2008

Genetic changes during the initiation and progression of prostate cancer have eluded scientists to date. Now for the first time researchers have identified a specific gene expression profile of prostate cancer stem cells, with important implications for future treatments. The findings, published in BioMed Centrals open access journal Genome Biology, revealed 581 genes that are differentially expressed in certain prostate cancer cells, highlighting several pathways important in the cancer stem-cells biology, and offering targets for new chemopreventative and chemotherapeutic approaches.

The cells in the study represent less than 0.1% of prostate cancer tumors, and have properties that mark them out as cancer stem cells. The cells renew themselves, are highly invasive, and have a longer lifetime than normal stem cells. They also feature a primitive epithelial phenotype and can differentiate to recapitulate phenotypes seen in prostate tumors. The cells are found in all stages and types of prostate cancer.

Expression profiling of prostate cancers typically uses tumor cell mass samples to identify individual genes. In this study, researchers harnessed advances in microarray and target labelling technologies to produce a functionally annotated expression profile of these prostate cancer stem cells.

The team, from the YCR Cancer Research Unit at the University of York and Pro-cure Therapeutics Ltd, created a malignant stem cell signature by combining genes significantly overexpressed in stem cells with those significantly overexpressed in malignant stem cells. Quantitative RT-PCR, flow cytometry and immunocytochemistry were used to validate the gene expression changes.

Genes associated with inflammation were prominent in the cancer stem cell expression profile. Potential therapeutic target NFκB is known to promote cell survival. The researchers showed that an NFκB inhibitor triggered programmed cell death in cancer stem cells, but spared normal stem cells. This provides a potential therapeutic target for this rare group of cells, which are unlikely to be affected by current chemotherapy regimens.

For the first time we are looking at the subpopulation of cancer cells which actually initiate new tumors explains Anne Collins, who coordinated the study. The genetic profiling we have carried out should stimulate new lines of research directed towards stem cell treatments for cancer


'/>"/>

Contact: Charlotte Webber
charlotte.webber@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Related medicine news :

1. Mapping tool allows emergency management personnel to visually track resources
2. Language centers revealed, brain surgery refined with new mapping
3. Radiation for Prostate Cancer Raises Risk of Other Cancers
4. MR imaging accurately determines prostate cancer treatment failure
5. New data show benefit of finasteride in preventing prostate cancer
6. Prostate Cancer Vaccine Looks Promising in Early Trial
7. Genes Play Part in Prostate Cancer Among Races
8. Lowering Dietary Fat May Help Prevent Prostate Cancer
9. Reducing intake of dietary fat prevents prostate cancer in mice
10. AUA 2008: Access to urologists and prostate cancer screenings lead to better outcomes for patients
11. Regular prostate-specific antigen screening may be discontinued in certain elderly populations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... , ... The annual time frame to change Medicare health and prescription drug ... 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their current plan to ... make changes during this period order for their new policy to go into effect ...
(Date:12/2/2016)... ... December 02, 2016 , ... More than half of American teens ... of parents report speaking with their child about sex related topics, less than 60 ... Mediaplanet is proud to announce the launch of its second edition of the “Sexual ...
(Date:12/2/2016)... , ... December 02, 2016 , ... Sourced from the ... some unique properties including its unmatched natural purity of just 6 ppm TDS (Total ... crisp. , Nothing Water has been available in several ShopRite and FoodTown stores in ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... meals to needy individuals and families from eight different sites throughout Miami-Dade and ... Day. Over 1,000 volunteers worked very hard on Thanksgiving morning by putting together ...
(Date:11/30/2016)... Northridge, CA (PRWEB) , ... November 30, 2016 ... ... Elyson, announce that they now offer a comprehensive in-house dental plan for all ... dentists have developed a plan that gives patients a number of perks, including ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016  PipelineRx, a leading medication management technology ... demonstrations of its SaaS-based telepharmacy platform, PowerGridRx™ ... 2016 Midyear Clinical Meeting and Exhibition, December 5-7 ... nearly 300 hospital clients nationally, the Company is ... to dramatically improve pharmacy operations, enhance patient safety, ...
(Date:12/2/2016)... 2, 2016  Maxor National Pharmacy Services, LLC ("Maxor"), today ... Inc. ("PSI").  The combination of Texas -based ... -based PSI bring together both company,s clinical expertise and high-touch ... an industry-leading specialty pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... 2016 Lianluo Smart Limited (Nasdaq: ... which develops, markets and sells medical devices and ... and international markets, recently attended the ... New Progress Forum, co-hosted by the Institute of ... , Guangdong Provincial People,s Hospital and Cardiology Department ...
Breaking Medicine Technology: