Navigation Links
Many solid tumors carry genetic changes targeted by existing compounds
Date:5/31/2013

CHICAGO, IL (May 28, 2013)Nearly two-thirds of solid tumors carry at least one mutation that may be targeted, or medicated, by an existing compound, according to new findings from researchers Fox Chase Cancer Center that will be presented at the 49th Annual Meeting of the American Society of Clinical Oncology on June 3. The results suggest that it may one day become commonplace for doctors to sequence tumors before deciding on a treatment regimen.

"Extended sequencing of a patient's tumor is not something that's routinely done now," says study author Patrick Boland, MD, a hematology/oncology fellow at Fox Chase. "Our ultimate hope is that, if we determine testing is worthwhile, it becomes routine for a doctor to send off a tumor sample to look for mutations before deciding on a course of treatment."

In some forms of cancer, such as lung cancer, doctors do check for a limited number of mutations. Mutations found with this focused testing only affect the treatment of a small proportion of patients. However, most tumors likely have many mutations, some of which may be targeted specifically by drugs already on the market, or under development.

To investigate, 77 patients with solid tumorsprimarily inflammatory breast cancer and colon cancer underwent genetic profiling looking for nearly 200 mutations associated with cancer. Boland and his co-author Alan Skarbnik reviewed the DNA sequencing to analyze the net results of testing and consider the potential impact on patient care.

Most of the patients96%carried one mutation or more. Nearly two-thirds had at least one mutation the researchers termed "actionable," meaning it is targeted by a drug that is on the market or in development. Many of the mutations were amplifications, in which multiple copies of a single gene were present, which ramps up its effect on the body.

Boland stresses that even though these genetic alterations are present, in many cases it's not clear wh
'/>"/>

Contact: Diana Quattrone
diana.quattrone@fccc.edu
215-815-7828
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Jersey Court Consolidates Statewide Mirena IUD Lawsuits, Rottenstein Law Group LLP Reports
2. Stryker Rejuvenate Attorneys at Kershaw, Cutter & Ratinoff Push for Cases to be Consolidated and Fought in U.S. District Court in Chicago, Illinois
3. Stryker Hip Recall Lawyers at Gilman Law LLP Look Forward to Upcoming Hearing on Stryker Rejuvenate and ABG II Hip Lawsuit Consolidation
4. Cymbet EnerChip Solid State Batteries Verified 100% Biocompatible
5. Smith & Nephew Hip Recall News: Bernstein Liebhard LLP Notes Motion to Consolidate Smith & Nephew Lawsuits Filed in Tennessee State Courts
6. Solid-state controllable light filter may protect preterm infants from disturbing light
7. Transvaginal Mesh Complications Lawsuits Update: Resource4thePeople Reports Some CasesDismissed from Consolidated Litigation
8. New Instrument for High-Precision Measurements of Soy Milk Solids and Protein Concentration
9. Consolidated Facility Advises Spring Cleaning Done Now in Davis Businesses
10. AACR: Positive data supports advancing BIND-014 to phase 2 clinical trials for solid tumors
11. Researchers to develop next generation immunotherapy for children with deadly solid tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... For people who are keen on the ... Market Research Report would be an useful report to ... the present market scenario of this industry. The report ... market of this industry. The report summarizes key statistics ... manufacturers in this industry. The report is a valuable ...
(Date:5/24/2015)... May 24, 2015 ProPin is a ... Cut Pro X. Utilize ProPin to pin point locations on ... scene. , ProPin allows users to choose from 30 ... FCPX. With on-screen controls, video editors can easily manipulate ProPin ... pin and mark with absolute ease. , Using ProPin is easy, ...
(Date:5/23/2015)... City, FL (PRWEB) May 23, 2015 On ... to build a new playground for Branches Florida City exactly ... the former play space in 2010. , A large fire ... new playground on May 23, 2010 in the middle of ... watched. The fire was later declared arson even though it ...
(Date:5/23/2015)... On May 16, the team at Farrell’s eXtreme ... mud obstacle run that raised funds for multiple sclerosis. ... the reason we participated was to support people living with ... eXtreme Bodyshaping. “One-hundred percent of the funds raised go to ... not only attended by eXtreme Bodyshaping staff, but members of ...
(Date:5/23/2015)... (PRWEB) May 23, 2015 Injury lawyer Steven ... has been passed by the Maryland legislature but which has ... Maryland General Assembly passed HB 449 with overwhelming ... has not signed it into law. This bill ensures that ... is growing that demonstrates the danger of fracking to our ...
Breaking Medicine News(10 mins):Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 2Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 3Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 4Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Five Years After Fire, Branches Rebuilds Playground 2Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3
... (BRONX, NY) Older women with hypertension are at ... later in life, according to data from the Women,s ... in the December 2009 online issue of the ... conducted as part of the Women,s Health Initiative (WHI), ...
... stem cell transplantation can extend "event-free survival" for breast ... breast cancer with and without distant metastases. However, there ... can more frequently give rise to severe complications affecting ... the final report of the Institute for Quality and ...
... in Vision and Ophthalmology is honored to announce this ... Fellow recognizes members for their accomplishments, leadership and contributions ... ARVO anticipates that Fellows will continue to serve as ... vision and ophthalmology research and to further ARVO,s vision ...
... , MOUNTAIN VIEW, Calif. , Jan. 12 ... a leading provider of medication system solutions to acute healthcare facilities, ... as its primary vendor for automated medication management solutions. , "To ... need a system that can account for and monitor medications from ...
... Jan. 12 United American Healthcare Corporation (Nasdaq: UAHC ... for the Company,s Annual Meeting of Shareholders as well as the record ... Annual Shareholders, Meeting will be held on Friday, April 23, 2010 ... 1777 Third Street in Detroit .  Shareholders of record as of ...
... government took big steps to stem smoking, while most states ... U.S. government took some important steps last year to prevent ... grade and 10 made alarming cuts to their tobacco control ... Tobacco Control 2009 report, released Tuesday by the American ...
Cached Medicine News:Health News:Hypertension linked to dementia in older women 2Health News:Hypertension linked to dementia in older women 3Health News:Women with breast cancer may benefit from autologous stem cell transplantation 2Health News:Women with breast cancer may benefit from autologous stem cell transplantation 3Health News:Women with breast cancer may benefit from autologous stem cell transplantation 4Health News:ARVO announces 2010 fellows 2Health News:ARVO announces 2010 fellows 3Health News:ARVO announces 2010 fellows 4Health News:NewYork-Presbyterian Hospital Selects Omnicell for Medication Management 2Health News:NewYork-Presbyterian Hospital Selects Omnicell for Medication Management 3Health News:NewYork-Presbyterian Hospital Selects Omnicell for Medication Management 4Health News:United American Healthcare Corporation Announces Meeting Date and Record Date for Annual Meeting of Shareholders 2Health News:United American Healthcare Corporation Announces Meeting Date and Record Date for Annual Meeting of Shareholders 3Health News:Report Card on Tobacco Control Laws a Mixed Bag 2Health News:Report Card on Tobacco Control Laws a Mixed Bag 3Health News:Report Card on Tobacco Control Laws a Mixed Bag 4
(Date:5/22/2015)... Fla. , May 22, 2015 ... Heart Institute recently traveled to Boston, ... procedure at the 2015 Heart Rhythm Society conference. ... together to focus on the ideas, people and ... Convergent is a hybrid, minimally invasive cardiac ...
(Date:5/22/2015)... May 22, 2015  The U.S. Food and ... -- the first biosimilar product approved in ... toward growth in the contract manufacturing organization (CMO) ... industry is geared to the production of small-molecular ... biopharmaceutical products. The healthcare market research publisher,s report, ...
(Date:5/22/2015)... , May 22, 2015 ... Assay Market by Product (Consumables, Instruments, Services), by Test ... (ELISA, Chromatography, Flow Cytometry), by End Users - Global ... Assays Market is expected to reach $736.85 Million by ... CAGR of 10.25%. Browse 71 market ...
Breaking Medicine Technology:St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 3Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 2Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 3Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 4Oxidative Stress Assays Market Worth $736.85 Million by 2020 2Oxidative Stress Assays Market Worth $736.85 Million by 2020 3Oxidative Stress Assays Market Worth $736.85 Million by 2020 4
... USHIFU, LLC, a global leader in,non invasive high ... sponsorship of the Sonablate(R) International HIFU Registry,(SIHR), along ... and Takai,Hospital Supply Co., Ltd., (THS). The SIHR ... information about prostate cancer treatment using HIFU.,It was ...
... Benefits All Americans, WASHINGTON, July 9 In ... M.D., discussed the,safety and importance of the research programs ... as an absolute commitment to its patients,while expressing regret ... misused., "VA has an outstanding research program, and ...
Cached Medicine Technology:Sonablate(R) International HIFU Registry is the First Worldwide HIFU Clinical Registry for Prostate Cancer Treatments 2Sonablate(R) International HIFU Registry is the First Worldwide HIFU Clinical Registry for Prostate Cancer Treatments 3Secretary Reinforces VA's Commitment to Research Safety and Veteran Focus 2Secretary Reinforces VA's Commitment to Research Safety and Veteran Focus 3
LB Agar plates with 0.1mM EDTA....
Luria bertani broth: 1.0% Tryptone, 0.5% Yeast Extract, 1.0% Sodium Chloride....
2.5% Soytone, 4.8% Yeast Extract, 0.025% Magnesium Sulfate, 130mM Calcium Chloride....
12% Tryptone, 24% Yeast Extract, 4.0% Glycerol. Supplied with 1 liter of 10x phosphate buffer (0190-1L)....
Medicine Products: