Navigation Links
Many prostate cancer patients receive improper or 'mismatched' therapies
Date:11/25/2007

Prostate cancer patients often receive treatment that is contraindicated by pre-existing conditions, like urinary or bowel dysfunction, according to a new study. Dr. James Talcott of the Massachusetts General Hospital in Boston and co-investigators found that patients with certain pretreatment dysfunctions often receive contraindicated or mismatched therapies, which can lead to worse outcomes. The study is published in the January 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society.

The American Cancer Society estimates that more than 218,000 American men are diagnosed with prostate cancer and more than 27,000 die from the disease each year. The three most common treatments for the disease are external beam radiation, brachytherapy, and radical prostatectomy.

Clinical studies have found no differences in efficacy among the three major therapies for the treatment of prostate cancer, but each brings with it certain risks, such as urinary incontinence or sexual dysfunction. Therefore, the best therapy for a particular patient will depend on the individuals pre-treatment status. For example, patients with pre-existing bowel dysfunction should not receive external beam radiation as a first line of therapy because the treatment inevitably irradiates the adjacent rectum in addition to the prostate and causes acute and long-term bowel dysfunction. Similarly, patients with problematic urinary obstructive symptoms should not receive brachytherapy, which delivers radiation to the prostate and can cause complete obstruction in patients with pre-existing obstructive symptoms.

Dr. Talcott and his colleagues surveyed 438 patients who sought therapy for untreated, localized prostate cancer from several hospitals in the Boston area between June 1, 1994 and August 31, 2000. Several additional questionnaires were mailed to patients until 36 months after treatment, and medical records were reviewed.

The study shows that 389 patients reported pre-existing dysfunction, and more than one-third received mismatched treatments. Increasing clinical complexity of a patients condition had little effect on the likelihood of mismatched treatments. Patients who had a single baseline dysfunction that contraindicated one treatment were just as likely to be given a mismatched treatment as patients with weaker contraindications or patients for whom multiple treatments were contraindicated. As expected, mismatched brachytherapy and external beam radiation therapy led to worsened urinary and bowel symptoms, respectively.

The investigators plan to test whether incorporating prostate cancerspecific survey instruments into clinical practice may increase awareness of patient baseline dysfunction, reduce treatment mismatches, and improve outcomes.

The authors conclude that their observations raise concerns about physician-patient communication. Similar situations may also exist for other types of cancer, producing unsuspecting barriers to patient-centered choices of treatment, palliative care and hospice, say the authors.


'/>"/>

Contact: Amy Molnar
amolnar@wiley.com
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. First biomarker discovered that predicts prostate cancer outcome
3. Frequent Prostate Screens Fail to Improve Aggressive Cancer Diagnoses
4. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
5. Us TOO Launches National SEA Blue Campaign for Prostate Cancer Awareness Month
6. Red wine compound shown to prevent prostate cancer
7. Barbershop Talks Cut Black Mens Prostate Cancer Risk
8. Generic prostate drug helps find high-risk cancers early
9. Finasteride unlikely to induce high grade prostate cancers
10. Shrinkage of prostate led to overestimation of cancer risk in trial
11. Prostate Cancer Awareness Week to Screen Thousands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Aliso Viejo, California (PRWEB) , ... June 26, 2016 , ... ... for Final Cut Pro X. , "Film editors can give their videos a whole ... artistically," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
Breaking Medicine Technology: