Navigation Links
Many patients who die while awaiting liver transplant have had donor organs declined
Date:11/5/2012

The majority of patients on the liver transplant waitlist who died received offers of high-quality donated livers that were declined prior to their death, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. Therefore, efforts other than simply increasing the availability of donated livers or the number of offers are needed to substantially reduce the deaths among those waiting for a transplant.

"Our findings suggest that waitlist deaths are not simply due to lack of donor organs, as many of us assume. Rather, deaths result from opportunities for transplantation that were declined," said John P. Roberts, MD, of the University of California San Francisco and lead author of this study. "Efforts should also be made to reduce the stigma associated with non-ideal livers and set realistic expectations for waitlisted candidates."

Researchers analyzed data from the United Network for Organ Sharing (UNOS) registry on all U.S. liver transplantation candidates who were offered livers from Feb. 1, 2005, to Jan. 31, 2010. Candidates were excluded if their Model for End-Stage Liver Disease (MELD) score which is used to prioritize the urgency for liver transplant was less than 15. Of 33,389 candidates for liver transplantation, researchers found that 20 percent died or were removed from the list, and 64 percent received a transplant. Among the subgroup of 6,787 transplant candidates who eventually died or were removed from the waitlist for being too sick, 84 percent had received at least one organ offer. More surprisingly, these candidates received not just one or two, but a median of six liver offers during their time on the waitlist.

"Donor quality/age" was cited as the most common reason for why transplant centers refused the organ. However, when organs considered "high quality" were analyzed, researchers found that 55 percent of transplant candidates who died or were removed from the waitlist before being transplanted had been offered at least one of these high-quality organs. This suggests that data from the UNOS/Organ Procurement Transplantation Network does not accurately or fully capture the true reason why these organs are refused. Understanding the real-time factors involved in these decisions is vital to improving the waitlist process for liver transplant candidates.

In a related editorial, Michael L. Volk, MD, MSc, and Carl L. Berg, MD, state that this study highlights the need to better inform patients about organ offers and to engage them in deciding whether to accept or decline such offers, rather than leaving this decision solely up to their physicians. Although it is assumed that most of these decisions are made with the best intent, it would be of interest to learn of patients' opinions about multiple organs being declined on their behalf.

Patients waiting for a liver transplant are prioritized by their risk of waitlist mortality, which is determined by their MELD score. Once a liver transplant becomes available, it is offered to the candidate who is first on the waitlist. Depending upon the quality of the donor liver relative to the perceived need of the candidate, this liver offer may be accepted for transplantation. However, the center to which the liver was offered can decline the organ, in which case, it will be offered to the candidate who is next on the waitlist, and similarly down the waitlist, until it is finally accepted for transplantation.


'/>"/>
Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Bypass Beats Stents for Diabetic Heart Patients: Study
2. Drug doesnt significantly lower risk of major heart problems in dialysis patients
3. Eating More Fruits, Veggies May Help Kidney Patients
4. Combination treatment may improve survival of breast cancer patients with brain metastases
5. Stem cells show promise for treating infertility in cancer patients
6. Cancer Drug Reduced Relapses in MS Patients: Studies
7. Study: Repeated surgeries appear to extend life of patients with deadliest of brain cancers
8. Patients with diabetes left in the dark
9. Black Breast Cancer Patients May Have Higher Death Risk in First 3 Years
10. Automated calls help patients in under-developed countries manage blood pressure, U-M study finds
11. Controlling depression is associated with improved health for heart-failure patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses and ... stories, which come courtesy of leaders in the nursing and health care industry. It ... advocates and associations—namely Abilene Christian University. , As the nursing industry is coming ...
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports hinting ... and company to wait until March 2017 for an interest rate increase, according to ... College of Business. , “The Federal Open Market Committee (FOMC) dot charts are of ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... thousands of defective respirators, according to court documents and SEC filings. A ... and Becky Tyler v. American Optical Corporation, Case No. BC588866, Los Angeles County, ...
(Date:5/26/2016)... ... ... Connor Sports, through its Connor Cares initiative, will continue to expand ... Tour that will commemorate the Indiana Fever legend’s hall-of-fame career and final WNBA ... levels of the game, Connor Sports has committed to a significantly increased focus on ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... one that has a significant negative impact on long-term patient survival, reports a ... The results, published online this week in the Journal of Thoracic and Cardiovascular ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... FDA 510(k) clearance covers ... for urological and surgical applications Mauna ... Cellvizio®, the multidisciplinary confocal laser endomicroscopy (CLE) platform, ... US with the 12 th 510(k) clearance ... This new FDA clearance covers Confocal Miniprobes indicated ...
(Date:5/25/2016)... May 25, 2016  Zymo Research Corp. announced ... new reference materials that help researchers obtain the ... to analyses. The rapid growth of the study ... to have standard methods to improve the reproducibility ... inherently exist at every step of the measurement ...
(Date:5/25/2016)... , May 25, 2016  Granger Diagnostics today ... test for wounds and infections. This test ensures ... and select viruses. The test requires only a ... David G. Bostwick , MD, ... to facilitate wound healing: "We are excited to ...
Breaking Medicine Technology: