Navigation Links
Many patients who die while awaiting liver transplant have had donor organs declined
Date:11/5/2012

The majority of patients on the liver transplant waitlist who died received offers of high-quality donated livers that were declined prior to their death, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. Therefore, efforts other than simply increasing the availability of donated livers or the number of offers are needed to substantially reduce the deaths among those waiting for a transplant.

"Our findings suggest that waitlist deaths are not simply due to lack of donor organs, as many of us assume. Rather, deaths result from opportunities for transplantation that were declined," said John P. Roberts, MD, of the University of California San Francisco and lead author of this study. "Efforts should also be made to reduce the stigma associated with non-ideal livers and set realistic expectations for waitlisted candidates."

Researchers analyzed data from the United Network for Organ Sharing (UNOS) registry on all U.S. liver transplantation candidates who were offered livers from Feb. 1, 2005, to Jan. 31, 2010. Candidates were excluded if their Model for End-Stage Liver Disease (MELD) score which is used to prioritize the urgency for liver transplant was less than 15. Of 33,389 candidates for liver transplantation, researchers found that 20 percent died or were removed from the list, and 64 percent received a transplant. Among the subgroup of 6,787 transplant candidates who eventually died or were removed from the waitlist for being too sick, 84 percent had received at least one organ offer. More surprisingly, these candidates received not just one or two, but a median of six liver offers during their time on the waitlist.

"Donor quality/age" was cited as the most common reason for why transplant centers refused the organ. However, when organs considered "high quality" were analyzed, researchers found that 55 percent of transplant candidates who died or were removed from the waitlist before being transplanted had been offered at least one of these high-quality organs. This suggests that data from the UNOS/Organ Procurement Transplantation Network does not accurately or fully capture the true reason why these organs are refused. Understanding the real-time factors involved in these decisions is vital to improving the waitlist process for liver transplant candidates.

In a related editorial, Michael L. Volk, MD, MSc, and Carl L. Berg, MD, state that this study highlights the need to better inform patients about organ offers and to engage them in deciding whether to accept or decline such offers, rather than leaving this decision solely up to their physicians. Although it is assumed that most of these decisions are made with the best intent, it would be of interest to learn of patients' opinions about multiple organs being declined on their behalf.

Patients waiting for a liver transplant are prioritized by their risk of waitlist mortality, which is determined by their MELD score. Once a liver transplant becomes available, it is offered to the candidate who is first on the waitlist. Depending upon the quality of the donor liver relative to the perceived need of the candidate, this liver offer may be accepted for transplantation. However, the center to which the liver was offered can decline the organ, in which case, it will be offered to the candidate who is next on the waitlist, and similarly down the waitlist, until it is finally accepted for transplantation.


'/>"/>
Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Bypass Beats Stents for Diabetic Heart Patients: Study
2. Drug doesnt significantly lower risk of major heart problems in dialysis patients
3. Eating More Fruits, Veggies May Help Kidney Patients
4. Combination treatment may improve survival of breast cancer patients with brain metastases
5. Stem cells show promise for treating infertility in cancer patients
6. Cancer Drug Reduced Relapses in MS Patients: Studies
7. Study: Repeated surgeries appear to extend life of patients with deadliest of brain cancers
8. Patients with diabetes left in the dark
9. Black Breast Cancer Patients May Have Higher Death Risk in First 3 Years
10. Automated calls help patients in under-developed countries manage blood pressure, U-M study finds
11. Controlling depression is associated with improved health for heart-failure patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... NY (PRWEB) , ... October 13, 2017 , ... Ellevate ... people in business to advocate for action towards gender equality at their inaugural Summit ... from around the globe, and reached a social audience of over 3 million. To ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and ... explains one of the most popular and least understood books in the Holy Scriptures, ... puzzling descriptions that have baffled scholars for centuries. Many have tossed it off as ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
(Date:9/12/2017)... -- Consumer reviews on the independent review site Consumer Affairs ... for hearing aids, ranking it higher than Miracle Ear ™, ... ... Hearing Aids ... store that provides high performance, state-of-the-art, German-engineered hearing aids directly to ...
(Date:9/9/2017)... ... to Washington DC ... September 12 th – Monday, September 18 th .The Brain Tumor ... brain scans to the public.Where:  BTF,s Mobile MRI ... K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, the Road to ...
Breaking Medicine Technology: