Navigation Links
Many causes for learning lags in tumor disorder
Date:12/21/2012

The causes of learning problems associated with an inherited brain tumor disorder are much more complex than scientists had anticipated, researchers at Washington University School of Medicine in St. Louis report.

The disorder, neurofibromatosis 1 (NF1), is among the most common inherited pediatric brain cancer syndromes. Children born with NF1 can develop low-grade brain tumors, but their most common problems are learning and attention difficulties.

"While one of our top priorities is halting tumor growth, it's also important to ensure that these children don't have the added challenges of living with learning and behavioral problems," says senior author David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of Neurology. "Our results suggest that learning problems in these patients can be caused by more than one factor. Successful treatment depends on identifying the biological reasons underlying the problems seen in individual patients with NF1."

The study appears online in Annals of Neurology.

According to Gutmann, who is director of the Washington University Neurofibromatosis Center, scientists are divided when considering the basis for NF1-associated learning abnormalities and attention deficits.

Mutations in the Nf1 gene can disrupt normal regulation of an important protein called RAS in the hippocampus, a brain region critical for learning. Initial work from other investigators had shown that increased RAS activity due to defective Nf1 gene function impairs memory and attention in some Nf1 mouse models.

However, earlier studies by Gutmann and collaborator David F. Wozniak, PhD, research professor in psychiatry, showed that a mutation in the Nf1 gene lowers levels of dopamine, a neurotransmitter involved in attention. In this Nf1 mouse model, Gutmann and his colleagues found that the branches of dopamine-producing nerve cells were unusually short, limiting their ability to make and
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study reveals how cancer drug causes diabetic-like state
2. What Causes Hot Flashes, Anyway?
3. No Proof That Gum Disease Causes Heart Disease, Experts Say
4. A new Achilles heel in fungus that causes dandruff
5. Cone beam CT proves better for visualizing some causes of hearing loss at half the radiation dose
6. Infection Causes 1 in 6 Cancers Worldwide: Study
7. Pneumonia and preterm birth complications are the leading causes of childhood death
8. Scientists discover gene which causes rare disease in babies
9. 3-center study identifies main causes of unprofessional behavior among hospitalists
10. Obesity, depression found to be root causes of daytime sleepiness
11. Food elimination diet identifies causes of difficulty swallowing and swelling of the throat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Akeso Biomedical, Inc. , a privately ... bacterial infections, microbial biofilms, and chronic wounds, announced that ... directors. , Dr. Sinskey is a ... Institute of Technology, or MIT. He has been a ... also holds positions as Co-Director of the Malaysia-MIT Biotechnology ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... undergoing in vitro fertilization (IVF) are only about half as ... assisted reproduction technique, new research indicates, and the racial disparity ... study, about 31 percent of white patients became pregnant after ... Analyzing more than 4,000 IVF cycles over two years to ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... may lead to increased blood pressure, according to a new ... in blood pressure for young adult women or for teenagers, ... drank lightly or moderately, their risk of high blood pressure ... parallels studies in older adult men and women," said lead ...
(Date:10/22/2014)... Measures taken by Firestone officials at the company,s ... the spread of the disease there and could prove ... Co. provides health services to about 80,000 employees, retirees, ... Between Aug. 1 and Sept. 23, there were ... people. That incidence rate of 0.09 percent was much ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... was diagnosed with Ebola while working for NBC News ... leave the special isolation unit at Nebraska Medical Center in Omaha, ... hospital said Tuesday. A blood test confirmed by the U.S. ... can head home to Providence, R.I., NBC News reported ...
Breaking Medicine News(10 mins):Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3
... will have the condition, experts say , , FRIDAY, Jan. 4 (HealthDay ... disability in the United States and now affects 46 million Americans, ... major new report finds. , That number is expected to rise ... percent of American adults will suffer from some form of arthritic ...
... for 29 categories of awards in the 2007 Association ... Best Monthly Professional Society Magazine as well as the ... winners will be honored at the Salute to Association ... 1996, JBS is the official publication of the Society ...
... 4 Align Technology,Inc. (Nasdaq: ALGN ), ... teeth without wires and brackets, announced today that ... end financial results on,Tuesday, January 29, 2008, after ... over PR Newswire and First Call and will ...
... CryoCor, Inc. (Nasdaq:,CRYO), a medical device company ... the publication of a European study of atrial,fibrillation ... of the study was to evaluate the role ... and the effectiveness of an ablation,strategy focused on ...
... El SEGUNDO, Calif., Jan. 4 DaVita Inc. ... Institute, PLC (,SKI,),have formed a wide-ranging partnership to ... chronic kidney disease education and research,in the greater ... SKI,s,existing dialysis centers and programs designed to provide ...
... COLUMBUS, Ohio, Jan. 2 Roxane Laboratories, ... New Drug Application (ANDA),for Granisetron Hydrochloride Tablets, ... The product is available in Unit Dose ... wholesalers and pharmacies nationwide., (Logo: ...
Cached Medicine News:Health News:46 Million Americans Suffer From Arthritis 2Health News:46 Million Americans Suffer From Arthritis 3Health News:Align Technology to Announce Fourth Quarter and 2007 Year End Financial Results on January 29, 2008 2Health News:Align Technology to Announce Fourth Quarter and 2007 Year End Financial Results on January 29, 2008 3Health News:CryoCor Reports Publication in Circulation for Treatment of Atrial Fibrillation 2Health News:CryoCor Reports Publication in Circulation for Treatment of Atrial Fibrillation 3Health News:Roxane Laboratories, Inc. Announces the Launch of Granisetron Hydrochloride Tablets, 1mg 2
(Date:10/22/2014)... Inc. (NYSE: CRY ), a leading medical ... vascular surgery, announced today that James Patrick (Pat) ... elected to the Company,s Board of Directors, effective October ... Executive Chairman of CryoLife, stated, "Since joining the Company in ... who is well positioned to maximize CryoLife,s potential.  His ...
(Date:10/22/2014)... -- Oramed Pharmaceuticals Inc. (NASDAQCM: ORMP) ... focused on the development of oral drug delivery ... its Phase IIa clinical trial of ORMD-0801, the ... 1 diabetes. The trial was conducted in ... Food and Drug Administration (FDA) Investigational New Drug ...
(Date:10/22/2014)... , Oct. 21, 2014  Early symptoms of ... or unnoticed, but new technology, coupled with yearly, ... leading to earlier detection of eye diseases, including ... million Americans. If left untreated, these diseases can ... Recently, optometric researchers have deployed ...
Breaking Medicine Technology:Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3
Epilation forceps straight ends size 3.5"....
Forceps, extra delicate, straight....
Jewelers Forceps, delicate, straight....
Jewelers Forceps, standard, straight....
Medicine Products: