Navigation Links
Many causes for learning lags in tumor disorder
Date:12/21/2012

The causes of learning problems associated with an inherited brain tumor disorder are much more complex than scientists had anticipated, researchers at Washington University School of Medicine in St. Louis report.

The disorder, neurofibromatosis 1 (NF1), is among the most common inherited pediatric brain cancer syndromes. Children born with NF1 can develop low-grade brain tumors, but their most common problems are learning and attention difficulties.

"While one of our top priorities is halting tumor growth, it's also important to ensure that these children don't have the added challenges of living with learning and behavioral problems," says senior author David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of Neurology. "Our results suggest that learning problems in these patients can be caused by more than one factor. Successful treatment depends on identifying the biological reasons underlying the problems seen in individual patients with NF1."

The study appears online in Annals of Neurology.

According to Gutmann, who is director of the Washington University Neurofibromatosis Center, scientists are divided when considering the basis for NF1-associated learning abnormalities and attention deficits.

Mutations in the Nf1 gene can disrupt normal regulation of an important protein called RAS in the hippocampus, a brain region critical for learning. Initial work from other investigators had shown that increased RAS activity due to defective Nf1 gene function impairs memory and attention in some Nf1 mouse models.

However, earlier studies by Gutmann and collaborator David F. Wozniak, PhD, research professor in psychiatry, showed that a mutation in the Nf1 gene lowers levels of dopamine, a neurotransmitter involved in attention. In this Nf1 mouse model, Gutmann and his colleagues found that the branches of dopamine-producing nerve cells were unusually short, limiting their ability to make and
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study reveals how cancer drug causes diabetic-like state
2. What Causes Hot Flashes, Anyway?
3. No Proof That Gum Disease Causes Heart Disease, Experts Say
4. A new Achilles heel in fungus that causes dandruff
5. Cone beam CT proves better for visualizing some causes of hearing loss at half the radiation dose
6. Infection Causes 1 in 6 Cancers Worldwide: Study
7. Pneumonia and preterm birth complications are the leading causes of childhood death
8. Scientists discover gene which causes rare disease in babies
9. 3-center study identifies main causes of unprofessional behavior among hospitalists
10. Obesity, depression found to be root causes of daytime sleepiness
11. Food elimination diet identifies causes of difficulty swallowing and swelling of the throat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... FL (PRWEB) August 30, 2014 McLeod's ... full service auto repair shop with strong ties to the ... Family is happy to announce they have been chosen by ... one pick for auto repair. , Tim McLeod’s father, ... Auto Service sixty years ago. Although his son, Tim runs ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 As 500 Zoloft ... defect when give to pregnant mothers, Wright & Schulte LLC ... Cynthia M. Rufe. The remand in the Zoloft ... of 18 states and are involved in one SSRI ... to have their Zoloft birth defect lawsuit sent back to ...
(Date:8/30/2014)... 2014 Barton Associates, an industry leading ... tenens company , announces a new office location in ... Associates is headquartered in Peabody, MA, with additional staffing ... Jupiter, FL. , Barton Associates decided to ... for healthcare providers. The United States is in the ...
(Date:8/30/2014)... Celebrating its 25th year, Recovery Month ... the fact that millions of Americans lives have ... addiction and mental health disorders. Every September ... programs and other community groups to recognize the ... The rallying theme for Substance Abuse and ...
(Date:8/30/2014)... August 2014: The first expert consensus on ventricular ... current evidence on the diagnosis and management of ... from three continents. , The "EHRA/HRS/APHRS Expert Consensus ... EP Europace (1). It was written ... of the European Society of Cardiology (ESC), the ...
Breaking Medicine News(10 mins):Health News:McLeod's Sunset Park Auto Service Celebrates 60 Years Honored with Best of South Tampa 2Health News:Group of Plaintiffs in Zoloft Lawsuit Alleging SSRI Caused Birth Defect Are Granted Remand 2Health News:Group of Plaintiffs in Zoloft Lawsuit Alleging SSRI Caused Birth Defect Are Granted Remand 3Health News:Group of Plaintiffs in Zoloft Lawsuit Alleging SSRI Caused Birth Defect Are Granted Remand 4Health News:Group of Plaintiffs in Zoloft Lawsuit Alleging SSRI Caused Birth Defect Are Granted Remand 5Health News:Barton Associates Announces New Office Location in Austin, TX 2Health News:September is National Recovery Month: What the Connecticut Community for Addiction Recovery (CCAR) Wants You to Know 2Health News:September is National Recovery Month: What the Connecticut Community for Addiction Recovery (CCAR) Wants You to Know 3Health News:First expert consensus on ventricular arrhythmias published 2Health News:First expert consensus on ventricular arrhythmias published 3
... heroes fighting for treatment, ARLINGTON, Va., Dec. ... Advocacy Center today announced that Karen,Gherardini (Illinois), Janice ... annual Torrey Advocacy Commendation. The,Treatment Advocacy Center (TAC) ... to the timely and effective treatment of,severe mental ...
... 17 Many medications,reduce the risk of bone ... used drugs - bisphosphonates- have not been proven ... funded by the Agency for,Healthcare Research and Quality ... Human Services., The AHRQ report compared the ...
... changes to the S&P 500 and S&P SmallCap 600:, -- Range ... ) in the S&P 500 after the close of ... private in a deal expected to close on or about ... SLXP ) will replace Coherent Inc. (Nasdaq: COHR ...
... December 17, 2007 Nationally recognized Attention Deficit Hyperactivity Disorder ... speaking tour to discuss the symptoms of ADHD in adults ... the life of an adult living with this disorder. ... adults, or 9.2 million adults across the U.S. based on ...
... tailor prevention messages, according to a report in the ... JAMA/Archives journals. , Nearly 2 million Americans tan indoors ... the United States having doubled to nearly 30 million ... the article. Evidence that indoor tanning poses a serious ...
... surgery technique appears promising for the removal of cancer ... the December issue of Archives of OtolaryngologyHead & Neck ... trying to remove tonsils of patients with cancer through ... to background information in the article. If the cancer ...
Cached Medicine News:Health News:Treatment Advocacy Center Honors Three Grassroots Mental Illness Advocates 2Health News:Many Osteoporosis Medications Prevent Fractures, But None Is Proven Best 2Health News:Many Osteoporosis Medications Prevent Fractures, But None Is Proven Best 3Health News:Standard & Poor's Announces Changes to U.S. Indices 2Health News:Standard & Poor's Announces Changes to U.S. Indices 3Health News:Adult ADHD significantly impacts on social, financial and personal aspects of life 2Health News:Adult ADHD significantly impacts on social, financial and personal aspects of life 3Health News:Classifying indoor tanning behaviors can help physicians tailor prevention messages 2Health News:Robotic device appears useful for surgical removal of cancer involving the tonsils 2
(Date:8/29/2014)... 29, 2014 Research and Markets ... Cancer Therapeutics Market & Pipeline Insight 2014" report ... developed to prevent and eradicate the prevalence of cancer ... are confined to low specificity, safety and large number ... for a better solution. It has been discovered that ...
(Date:8/29/2014)... SPRING, Md. , Aug. 29, 2014  United ... that the U.S. District Court for the District of ... its favor in the company,s case against Sandoz, Inc. ... Judge Peter Sheridan ruled that U.S. Patent ... Inc., and enjoined Sandoz from marketing its generic product ...
(Date:8/29/2014)... PITTSBURGH , Aug. 29, 2014 /PRNewswire-iReach/ -- ChemImage ... at the Australian and New Zealand Forensic Science ... Forensic Sciences in Adelaide, Australia ... discussion concerning the advancements that hyperspectral imaging can ... Jeffrey Beckstead , Director of Product Development ...
Breaking Medicine Technology:Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2District Court Decision Received In Remodulin Patent Case 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3
... treatment for spine tumorsLAS VEGAS, Feb. 22 For orthopaedic ... is a personal as well as a professional mission. Her ... still remembers the incredible pain her cousin experienced when the ... Dr. Keyak and her colleagues at the University of ...
... and Efficacy Results Support Follow-on NEST-3 TrialCARLSBAD, Calif., ... by PhotoThera, Inc., transcranial laser therapy (TLT) for ... onset demonstrated improved outcomes for patients, but did ... post-hoc analysis in patients who had moderate to ...
Cached Medicine Technology:Breast Cancer Patients May Have a New Treatment Option When Cancer Spreads 2Breast Cancer Patients May Have a New Treatment Option When Cancer Spreads 3Results of NeuroThera Effectiveness and Safety Trial - 2 (NEST-2) Presented at International Stroke Conference 2009 2
... Lightweight mechanical brace for functional knee ... or LCL instabilities. Unique hinge design ... load on ACL. Does not require ... injured or repaired knee without migration ...
... Orthosis Custom-fitted static-progressive orthosis ... Goniometer version has calibrated ... metal contacts skin. Includes ... bag. One size fits ...
... Polyamide Hinge Wraparound design can ... fit. Multilock polyamide hinge prevents ... extension can be set for ... level. Provides medial/lateral support during ...
... the dynamic way to manage a contracture. ... effective in reducing contractures. Full ROM is ... therapies. Can also be used as a ... and soft tissue contractures. Use where ROM ...
Medicine Products: