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Many bodies prompt stem cells to change
Date:6/16/2014

tudies.

For example, the models explained the fluctuations experimentalists had observed in the expression of a master regulator, a protein called nanog, and its important role in maintaining a cell's pluripotency. Stem cells move from one steady state to the next on their journeys; in their calculations, they found a much higher level of nanog gene expression in what they called SC1, the basic stem cell, than in SC2, a stem cell that had moved to the second steady state. This matched what experiments had measured, the researchers said.

"This is still just a beginning," Wolynes said. "We're looking at embryonic stem cells now, but someday we want to treat the complete developmental program of organisms with hundreds of genes. We can see how these mathematics can scale up to that regime."


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Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

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