Navigation Links
Many bodies prompt stem cells to change
Date:6/16/2014

i of Nagoya University but now takes into account the fact that not one but many genes can be responsible for even a single decision in a cellular process.

"This is what Bin figured out, that one could generalize our 2003 model to be much more realistic about how several different proteins bind to DNA in order to turn it on or off," Wolynes said.

A rigorous theoretical approach to determine the transition pathways and rates between steady states was also important, Zhang said. "This is crucial for understanding the mechanism of how stem cell differentiation occurs," he said.

Wolynes said that because the stem cell is stochastic -- that is, its fate is not pre-determined -- "we had to ask why a gene doesn't constantly flip randomly from one state to another state. This paper for the first time describes how we can, for a pretty complicated circuit, figure out there are only certain periods during which the flipping can occur, following a well-defined transition pathway."

In previous models of gene networks, "Instead of focusing on proteins actually binding to DNA, they just say, 'Well, there's a certain high level of this protein or low level of that protein,'" Wolynes said. "At first, that sounds easier to study because you can measure how much protein you've got. But you don't always know if it is bound. It has become increasingly clear that the rate of protein binding to DNA plays an important role in gene expression, particularly in eukaryotic systems."

The notion that many-body effects even existed in cells began in 1942 when British scientist C.H. Waddington established the idea of an epigenetic landscape for stem cells as a way to describe why pluripotent cells in embryos are destined to turn into bone, muscle and all the other parts of the body but don't turn back. Waddington compared the cells' paths to marbles rolling to the bottom of a valley.

That concept rang true to Wolynes. His energy landscape
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. No correlation between baby formulas and development of diabetes-associated autoantibodies
2. Understanding the unique nature of childrens bodies and brains
3. Antibodies from the desert as guides to diseased cells
4. Oxford University Press releases Trans Bodies, Trans Selves
5. A civil war inside our cells: Scientists show how our bodies fight off jumping genes
6. NIH grantees sharpen understanding of antibodies that may cut risk of HIV infection
7. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
8. Monoclonal Antibodies Market in Gastric and Esophageal Cancers to Reach USD 766 Mln by 2019, Says GBI Research in Its Report Available at MarketPublishers.com
9. Higher mortality in postmenopausal women with RA and anti-CCP antibodies
10. Maine Biotechnology Services-USDA-ARS Partnership Provides Monoclonal Antibodies to Aid in the Containment of Rift Valley Fever Virus
11. Ben-Gurion U. and Sorrento Therapeutics sign agreement to develop anti-hepatitis C virus antibodies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Many bodies prompt stem cells to change
(Date:7/22/2014)... 2014 5i Sciences, a medical technology ... of Molly Coye, M.D., M.P.H. to a role as ... authority on the market introduction of innovative technologies that ... will advise on strategies for building a successful commercial ... Dr. Coye is currently the Chief Innovation Officer ...
(Date:7/22/2014)... 2014 The Middle East Drilling fluid and ... and completion fluid market in Middle East with analysis and ... in Middle East is estimated to grow from around $560 ... CAGR of 5.7%, for the given period. , Browse through ... fluid Market report, to get an idea of the in-depth ...
(Date:7/22/2014)... Marine threats from human or natural agents ... and international criminal and piracy threats have created ... systems. Due to this the worldwide revenue of ... 2014 and is expected to reach $20.87 billion ... expected to grow at a CAGR of 8.40%. ...
(Date:7/22/2014)... Steven Reinberg HealthDay Reporter ... tests may one day help predict survival and the course ... also called Lou Gehrig,s disease, Italian researchers report. , , ... how fast ALS is progressing are called albumin and creatinine. ... health, according to the U.S. National Library of Medicine. ...
(Date:7/22/2014)... has received a five-year, $3 million grant to ... neglect and maltreatment during childhood leave molecular marks ... life. , The Center for Biomarker Research and ... in collaboration with Duke University School of Medicine, ... by the National Institutes of Health, National Institute ...
Breaking Medicine News(10 mins):Health News:5i Sciences Announces Appointment of a Senior Healthcare Consultant and Successful Financing 2Health News:Middle East Drilling Fluid & Completion Fluid Market is Expected to Reach $740 Million in 2018 - New Report by MicroMarket Monitor 2Health News:Middle East Drilling Fluid & Completion Fluid Market is Expected to Reach $740 Million in 2018 - New Report by MicroMarket Monitor 3Health News:Middle East Drilling Fluid & Completion Fluid Market is Expected to Reach $740 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Middle East Drilling Fluid & Completion Fluid Market is Expected to Reach $740 Million in 2018 - New Report by MicroMarket Monitor 5Health News:Middle East Drilling Fluid & Completion Fluid Market is Expected to Reach $740 Million in 2018 - New Report by MicroMarket Monitor 6Health News:North America Maritime Security Market is Expected to Reach $4.76 billion in 2019 - New Report by MicroMarket Monitor 2Health News:North America Maritime Security Market is Expected to Reach $4.76 billion in 2019 - New Report by MicroMarket Monitor 3Health News:North America Maritime Security Market is Expected to Reach $4.76 billion in 2019 - New Report by MicroMarket Monitor 4Health News:Blood Test Might Help Predict Survival With Lou Gehrig's Disease 2Health News:Blood Test Might Help Predict Survival With Lou Gehrig's Disease 3Health News:VCU receives grant to study molecular marks left by childhood adverse experiences 2
... ... Programs Aimed at Helping College Students Stay Fit , ... Los Angeles, CA (PRWEB) July 1, 2010 -- O2 MAX Fitness , a ... the use of social media and dynamic programs, will unveil a whole new line of initiatives ...
... , THURSDAY, July 1 (HealthDay News) -- ... uterine fibroids and helps women with the non-cancerous tumors ... pain and heavy menstrual bleeding, are a leading cause ... "Both the fibroids and the surgical interventions commonly used ...
... The Good Nite ... (Parent Tested, Parent Approved) awards their industry-renowned seal of approval to products that its parent ... , ... -- The Good Nite Lite has been awarded the Parent Tested Parent Approved ...
... Health cardiologists shows that while short-term worsening kidney function ... also have better outcomes than those who have persistent ... 2010 edition of the Journal of Cardiac Failure ... for patients with heart failure that develop kidney problems ...
... ... today that it has expanded the implementation of its state-of-the-art Electronic Medical Records (EMR) system ... Westchester, Rockland, Putnam and Orange Counties and northern New Jersey. All of our Westchester, Putnam, ... ...
... , ... Purity Products®, a leading direct-to-consumer provider of premium dietary supplements, announces the release ... relaxation. , ... (PRWEB) July 1, 2010 -- Purity Products®, a leading direct-to-consumer provider of ...
Cached Medicine News:Health News:Fighting Off the Freshman Fifteen 2Health News:Fighting Off the Freshman Fifteen 3Health News:Drug May Shrink Fibroids, Preserve Fertility 2Health News:The Good Nite Lite Awarded the Parent Tested Parent Approved Seal 2Health News:Study shows short-term kidney failure in heart patients may not be as detrimental 2Health News:ENT and Allergy Associates, LLP Expands its New Electronic Practice Management System (EMR) 2Health News:ENT and Allergy Associates, LLP Expands its New Electronic Practice Management System (EMR) 3Health News:Purity Products Releases Alpha 3C 2
(Date:7/22/2014)... , July 22, 2014 The number of ... 45 people each day. Twenty-three percent of the workforce ... on Drug Use and Health, making opioid use a ... taking opioid painkillers at the correct dosage with a ... Today, the National Safety Council released ...
(Date:7/22/2014)... July 22, 2014 BiologicTx ® today ... first 3-way Kidney Paired Donation transplant exchange utilizing BiologicTx,s ... on July 9 at the Miami Transplant Institute, located ... Kidney Paired Donation (KPD) ... compatible for kidney transplant with one another due to ...
(Date:7/22/2014)... , July 22, 2014 Elekta (NSE:EKTAb) and ... that The Christie NHS Foundation Trust ( Manchester, ... a consortium whose mission is to develop the clinical ... radiation therapy system. Such a system would, in principle, ... cancer targets. "The Christie was an ...
Breaking Medicine Technology:5 things employers should know about prescription painkiller use 25 things employers should know about prescription painkiller use 3BiologicTx Paired Donation Aids In Successful Kidney Transplants 2BiologicTx Paired Donation Aids In Successful Kidney Transplants 3The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 3The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 4
... 1 Neurobiological Technologies, Inc. (NTI(R)) (Nasdaq: ... a quarterly royalty payment of approximately $1.5 million ... Memantine for the treatment of Alzheimer,s disease. Under ... royalty payments on certain sales of Memantine by ...
... Inc. (OTC Bulletin Board: SCIE) , a San Diego based ... an article reporting that its LUMA cervical imaging system is enhancing ... . Since Last July, researchers at the University ... LUMA Cervical Imaging System in more than 80 women - in ...
Cached Medicine Technology:Des Moines Register Reports SpectraScience LUMA Enhances Cervical Cancer Exams 2Des Moines Register Reports SpectraScience LUMA Enhances Cervical Cancer Exams 3
UST-675-P is our end-fire prostate transducer. Multiple frequencies provide extraordinary imaging capabilities for your diverse patient population, and the biopsy guide enables accurate and fast pros...
Super High Density 360 degree radial rectal transducer. High resolution in the near field and lower frequencies for deeper penetration make this transducer the optimal choice when scanning the anal c...
Our most versatile transducer for superficial imaging. Wide Band, Super High Density, multi-frequency transducer with superb Doppler and color flow sensitivity make this an excellent choice for breas...
... 5545 linear transducer is our high ... superficial and vascular imaging. Multiple frequencies ... sensitivity combined with our exclusive transducer ... PixelFocus to provide excellent resolution and ...
Medicine Products: