Navigation Links
Many Prostate Cancers Will Not Need Treatment
Date:2/13/2008

Major study finds most older men will die of other causes

WEDNESDAY, Feb. 13 (HealthDay News) -- One of the largest studies of its kind concludes that most older men with early prostate cancer do not shorten their survival odds if they adopt a "wait-and-see" approach to the disease.

In fact, most such patients will die of other causes or they simply won't develop any complications from the cancer, the researchers found.

"Many elderly men with lower risk cancer may do well with conservative management," concluded study author Grace Lu-Yau, a cancer epidemiologist at the Cancer Institute of New Jersey, and an associate professor at UMDNJ-Robert Wood Johnson Medical School and School of Public Health.

"Each patient facing a treatment decision has to ask himself what is the potential survival benefit of various treatments and the potential side effects of various treatments, then compare this potential risk of side effects with the potential risk of cancer complications if the cancer is left untreated -- and ask themselves which treatment option is their personal preference," Lu-Yau said.

She presented the findings to reporters at a special teleconference Tuesday, part of the 2008 Genitourinary Cancers Symposium taking place in San Francisco.

The question of whether to treat or not treat prostate cancer has long absorbed experts.

Although one in six men in the United States will be diagnosed with prostate cancer in their lifetime, many of the malignancies are slow-growing, and there is currently no reliable way to identify which men will benefit from treatment. Better knowledge of the natural history of the disease (i.e., what happens without any treatment) would help guide treatment decisions, Lu-Yau said.

This study is one of the first to look at the natural history of prostate cancer since PSA (prostate-specific antigen) blood testing has become commonplace. PSA tests can detect a prostate cancer six to 13 years earlier than previous methods.

Lu-Yau and her colleagues looked at data on more than 9,000 men with Stage I or II prostate cancer diagnosed between 1992 and 2002 who did not undergo treatment. The mean age of participants was 77 years.

Seventy-two percent of these men died of other causes or didn't have enough cancer progression to warrant surgery or radiation, the researchers found. For the remaining 2,675 men who did receive treatment, the median time between diagnosis and start of therapy was more than 10 years.

Not surprisingly, men with less aggressive disease survived longer than those with more aggressive tumors.

"For elderly men with localized prostate cancer, the potential survival benefit for treatment is most likely modest, therefore it is very critical to weigh the risk of having side effects of various treatments with the risk of developing cancer-related complications down the road," Lu-Yau said. "The majority of patients will die of other causes or remain alive without significant major complications."

A second study presented at the conference found that giving salvage radiation therapy (SRT) to men whose PSA levels rise after having their prostate removed can reduce their risk of dying from the cancer by more than 60 percent.

SRT is typically given only after a recurrence, not after an initial diagnosis of prostate cancer, noted study lead author Dr. Bruce Trock, associate professor of urology, epidemiology, oncology and environmental health sciences at Johns Hopkins University School of Medicine in Baltimore. Existing studies have either not been large enough or long enough in duration to determine if SRT prolongs survival.

In this retrospective analysis of 635 men who had experienced a recurrence after having their prostate removed, 62 percent of those who did not receive any salvage therapy were still alive after 10 years, versus 86 percent of those who received SRT and 82 percent of those who received SRT plus hormone therapy.

Men whose PSA doubling time (the amount of time it took for PSA levels to double from when in first becomes detectable) was six months or less had the greatest benefit.

"If another study was able to replicate our data, it could lead to clinical trial that would eventually support a way to determine who should get immediate adjuvant radiation and who could wait until the time of recurrence to have SRT," Trock said. "The question is, could a benefit be achieved in some of these men if you waited to see whether they recurred or not?"

More information

There's more on prostate cancer at U.S. National Cancer institute.



SOURCES: Feb. 12, 2008, teleconference with Grace Lu-Yau, Ph.D., cancer epidemiologist, Cancer Institute of New Jersey and associate professor, UMDNJ-Robert Wood Johnson Medical School and School of Public Health, and Bruce Trock, M.D., associate professor, urology, epidemiology, oncology and environmental health sciences, Johns Hopkins University School of Medicine, Baltimore


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. GPS for the Prostate: System Keeps Radiation Therapy on Target
2. Whats good for the heart may be good for the prostate
3. Whats Good for the Heart May Be Good for the Prostate
4. Men who are continually active at work may have a decreased risk of prostate cancer
5. More Gene Variations Found That Raise Prostate Cancer Risk
6. U.S. Representatives Urge Critical Improvements in Prostate Cancer Detection
7. Henry Ford Hospital expands research on gene and radiation therapy for prostate cancer
8. NuView Radiopharmaceuticals, Inc. Secures Exclusive Rights From Thomas Jefferson University for a Tumor-Specific Imaging Agent for the Diagnosis of Breast and Prostate Cancers
9. Men Can Take Their Time to Decide on Prostate Cancer Treatment, Reports the Harvard Mens Health Watch
10. Online tool supports more dialogue on prostate cancer risk
11. Experimental Vaccine Halts Prostate Cancer in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Many Prostate Cancers Will Not Need Treatment
(Date:2/9/2016)... ... February 09, 2016 , ... ... Elder-Beerman, Herberger’s and Younkers department stores, announced it has raised $176,000 to benefit ... Center, Holden Comprehensive Cancer Center at the University of Iowa, The Lynn Sage ...
(Date:2/9/2016)... ... 09, 2016 , ... METTLER TOLEDO has published a new ... basic understanding of the techniques they use so they can more easily spot ... waste and rework to create a leaner overall lab experience. , The ...
(Date:2/9/2016)... ... 2016 , ... United Methodist Communications collaborated with Chocolate Moose ... video designed to prevent the next widespread Ebola outbreak from occurring ... distributed throughout Togo, Liberia, Sierra Leone, Nigeria, Côte d’Ivoire and other African countries, ...
(Date:2/9/2016)... Petersburg, FL (PRWEB) , ... February 09, 2016 , ... Shark Finds and ... a new DRTV campaign with GRIP-DRY. , GRIP-DRY is a newly patented product that has ... Golfers who play in the wet and early morning dew or right after a rain ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Federal Laboratory ... federallabs.org . The site houses a wealth of federal resources that businesses can ... process called technology transfer (T2). As a network of over 300 federal laboratories, ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016  Increasingly, health care ... their vital signs with wireless technology. With the Vios ... automate patient oversight and remotely detect problems before they ... signs across in-hospital environments. the United ... United States . --> The ...
(Date:2/9/2016)... Feb. 9, 2016 The new report " Global Fetal ... Spearhead Acuity Business Research & Consulting group reveals that ... market with a share of 36.4% in 2014 that translated into ... , the report also covers market analysis for Fetal and Neonatal ... , Asia-Pacific , Latin America ...
(Date:2/9/2016)... , Feb. 9, 2016  Bluestar Silicones will promote ... line for long-term implant applications and announce certification ... & Manufacturing (MD&M) West Conference (Booth #1759), February ... --> --> Available in ... LSRs offer outstanding physical properties enabling our customers ...
Breaking Medicine Technology: