Navigation Links
Many NIH-funded clinical trials go unpublished over 2 years after completion
Date:1/3/2012

In a study that investigates the challenges of disseminating clinical research findings in peer-reviewed biomedical journals, Yale School of Medicine researchers have found that fewer than half of a sample of trials primarily or partially funded by the National Institutes of Health (NIH) were published within 30 months of completing the clinical trial.

These findings appear in the January issue of the British Medical Journal, which focuses on the topic of unpublished evidence.

"When research findings are not disseminated, the scientific process is disrupted and leads to redundant efforts and misconceptions about clinical evidence," said Joseph Ross, M.D., first author of the study and a Yale assistant professor of medicine. "Such inaction undermines both the trial in question and the evidence available in peer-reviewed medical literature. This has far-reaching implications for policy decisions, and even institutional review board assessments of risks and benefits associated with future research studies."

Ross and co-authors performed a cross-sectional analysis of NIH-funded clinical trials registered within ClinicalTrials.gov, a trial registry and results database maintained by the U.S. National Library of Medicine. All trials in the study sample were registered after September 30, 2005 and completed by December 31, 2008, allowing at least 30 months for publication following completion of the trial.

They found that overall fewer than half of NIH-funded trials in the sample were published in a peer-reviewed, MEDLINE-indexed biomedical journal within 30 months of trial completion. They also found that one-third of trials remained unpublished 51 months after completion.

Ross said that there may be many reasons for lack of publication, such as not getting accepted by a journal or not prioritizing the dissemination of research findings. Still, he said, there are alternative methods for providing timely public access to study results, including the results database at ClinicalTrials.gov that was created in response to Federal law.

"Steps must be taken to ensure the timely dissemination of publicly funded research so that data from all those who volunteer are available to inform future research and practice," Ross said.

While this study was focused on trials funded by NIH, Ross said that similar problems with non-publication and delayed publication of research findings have been described among trials funded by the pharmaceutical and medical device industries, as well as by non-profit organizations.

"This suggests that the current culture of research needs to prioritize the timely public dissemination of research findings, ideally via peer-reviewed journals, for research funded by both public and private sources," said Ross. "More work needs to be done to better understand impediments to publication."


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related medicine news :

1. NIH-funded scientists identify potential malaria drug candidates
2. NIH-funded twin study finds occupational chemical exposure may be linked to Parkinsons risk
3. NIH-funded research points to potential therapy for tumor-associated epilepsy
4. Traumatic brain injury: NIH-funded researchers will assess biomarkers for diagnosis and treatment
5. NIH-funded researchers find new ways to confuse blood-seeking mosquitoes
6. NIH-funded study finds new possible risk factor of heart disease
7. NIH-funded study uses new technology to peek deep into the brain
8. In NIH-funded study, researchers uncover step in brain events leading up to addiction
9. NIH-funded study finds early HAART during TB treatment boosts survival rate in co-infected people
10. University of Mississippi Medical Center to lead in nationwide NIH-funded Alzheimers study
11. NIH-funded scientists find 2009 H1N1 pandemic influenza vaccine protects mice from 1918 flu virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... ... (IT) solutions and digital consulting services to the federal government, has been awarded ... Delivery / Indefinite Quantity (ID/IQ) contract in support of the U.S. Army Program ...
(Date:5/3/2016)... ... May 03, 2016 , ... Branches, Inc. is proud to ... Climb children and youth programs in South Miami. Macy’s is a wonderful community partner ... Grow Program provides afterschool tutoring, mentoring, enrichment and academic support to elementary students 5 ...
(Date:5/3/2016)... ... 03, 2016 , ... LunchSkins is changing the future of ocean ... single-use, throw away plastic baggies. The mission-driven bags give back to global leaders in ... LunchSkins mission is all about reducing global plastic waste and we’ve teamed ...
(Date:5/3/2016)... ... May 03, 2016 , ... The ... issued by the Office of the National Coordinator for Health IT (ONC) with ... action when necessary, including suspending and terminating certifications issued to Complete EHRs and ...
(Date:5/2/2016)... ... May 02, 2016 , ... ProElectric Cartoon is a package of 30 ... choose from a variety of electric styles including zap, sizzles, and more. Easily alter ... dof blur, three dimensional rotation, and much more. ProElectric Cartoon’s simplistic style makes it ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 28, 2016  While Abbott,s announced purchase of ... valve repair and stent business, healthcare research firm ... more firmly into patient monitoring.  Kalorama said that ... device areas, with double-digit growth expected the next ... Advanced Remote Patient Monitoring . Abbott Laboratories ...
(Date:4/28/2016)...  The blood testing market in China ... Information and The Freedonia Group in a recent report.  ... The healthcare research firm said that China ... stations and in improving testing at the provincial level.  ... Blood Testing Market in China , which ...
(Date:4/28/2016)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ( ... of oral drug delivery systems, announced today that the Company ... Joseph Gunnar & Co. LLC, taking place on ... Nadav Kidron , CEO of Oramed, will present a ...   PIONEERS 2016, presented by Joseph Gunnar ...
Breaking Medicine Technology: