Navigation Links
Many Heart Defects Aren't Inherited, Study Finds
Date:5/13/2013

SUNDAY, May 12 (HealthDay News) -- At least 10 percent of severe genetic heart defects are caused by new gene mutations that were not passed down from patients' parents, a new study finds.

Congenital heart disease is the most common form of birth defect and occurs in nearly 1 percent of newborns.

"These findings provide new insight into the causes of this common congenital disease," senior study author Richard Lifton, chair of the genetics department at the Yale School of Medicine, said in a university news release.

Lifton's tream analyzed the genes of more than 1,800 people and identified hundreds of mutations that can cause congenital heart disease. In particular, the investigators found that frequent mutations occurred in genes that affect what's known as histones. Histones are proteins that package DNA in the cell's nucleus and control the timing and activation of genes that may be key to fetal development.

The study was published online May 12 in the journal Nature.

"Most interestingly, the set of genes mutated in congenital heart disease unexpectedly overlapped with genes and pathways mutated in autism," Lifton said. "These findings suggest there may be common pathways that underlie a wide range of common congenital diseases."

"This is an important piece of the puzzle that gives us a clearer picture of the causes of congenital heart disease," Dr. Gary Gibbons, director of the U.S. National Heart, Lung, and Blood Institute, added in the news release. The institute funded the study.

More information

The March of Dimes has more about congenital heart defects.

-- Robert Preidt

SOURCE: Yale University, news release, May 12, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Mount Sinai Researchers Identify Gene Mutations in Congenital Heart Disease
2. Researchers take important step in unlocking what causes congenital heart disease
3. Pets a Boon for the Human Heart, Cardiologists Say
4. iPads Could Affect Implanted Heart Devices, Early Study Finds
5. Everyday Noise Levels May Affect the Heart
6. Swimming Pools May Pose Hazard for People With Heart Devices
7. Fish Oil Supplements Dont Protect Against Heart Trouble: Study
8. WomenHeart Wins “Full Circle Award” at the 4th M2W®-HW™ - The Marketing Health & Wellness to Women Conference
9. Docs Should Ask Heart Patients About Quality of Life
10. Heart Attack Preventing Drug, Plavix, Poses Continued Risk While Bristol-Myers Squibb Extends the Rights to Others for Generic OTC Versions
11. Duke scientists build a living patch for damaged hearts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Many Heart Defects Aren't Inherited, Study Finds
(Date:3/22/2017)... ... March 22, 2017 , ... Intrinsic ... extensive therapeutic experience and operational excellence in oncology clinical trials, proudly announces today ... the treatment of non-small cell lung cancer and small cell lung cancer. , ...
(Date:3/22/2017)... East Norwich, NY (PRWEB) , ... March 22, 2017 , ... ... services to communities in the greater Nassau County region, is embarking on a combined ... with breast cancer. , For the last 25 years, the Great Neck Breast ...
(Date:3/22/2017)... ... , ... Schneider Insurance and Financial, a southern Montana firm providing asset protection ... is launching a charity event aimed at raising local support for Zoo Montana. , ... and is home to a broad variety of animals from all over the world. ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... asset protection services and financial planning assistance to communities throughout central Ohio, is ... Brain Injuries. , Estimates from the Department of Defense and the Veteran's Brain ...
(Date:3/22/2017)... ... ... HumanHaus is proud to announce the launch of its newest invention on crowdfunding ... invented, but our customers today are busy, energetic, multi-taskers that live in a smarter ... and retired that want to travel. The Sweep&Stand is a self-standing broom ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017  Applied BioMath ( ... to drug research and development, today announced the ... QSP Day 2017 is a day full of ... systems pharmacology (QSP) community. The focus is to ... de-risking and accelerating drug research and development. ...
(Date:3/22/2017)... March 22, 2017 National Medical Products ... received an Innovative Technology contract from Vizient, ... in the country. The contract was based on ... with expertise in this category who serve on ... Technology contracts for technologies that demonstrate an ability ...
(Date:3/22/2017)...   Upsher-Smith Laboratories, Inc . (Upsher-Smith) today announced the ... mg and 75 mg, the generic equivalent to Mallinckrodt Pharmaceuticals, ... The clomipramine hydrochloride capsules market had U.S. sales of approximately ... to IMS Health. ... "Upsher-Smith has long been recognized within the pharmaceutical ...
Breaking Medicine Technology: