Navigation Links
Many Heart Defects Aren't Inherited, Study Finds
Date:5/13/2013

SUNDAY, May 12 (HealthDay News) -- At least 10 percent of severe genetic heart defects are caused by new gene mutations that were not passed down from patients' parents, a new study finds.

Congenital heart disease is the most common form of birth defect and occurs in nearly 1 percent of newborns.

"These findings provide new insight into the causes of this common congenital disease," senior study author Richard Lifton, chair of the genetics department at the Yale School of Medicine, said in a university news release.

Lifton's tream analyzed the genes of more than 1,800 people and identified hundreds of mutations that can cause congenital heart disease. In particular, the investigators found that frequent mutations occurred in genes that affect what's known as histones. Histones are proteins that package DNA in the cell's nucleus and control the timing and activation of genes that may be key to fetal development.

The study was published online May 12 in the journal Nature.

"Most interestingly, the set of genes mutated in congenital heart disease unexpectedly overlapped with genes and pathways mutated in autism," Lifton said. "These findings suggest there may be common pathways that underlie a wide range of common congenital diseases."

"This is an important piece of the puzzle that gives us a clearer picture of the causes of congenital heart disease," Dr. Gary Gibbons, director of the U.S. National Heart, Lung, and Blood Institute, added in the news release. The institute funded the study.

More information

The March of Dimes has more about congenital heart defects.

-- Robert Preidt

SOURCE: Yale University, news release, May 12, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Mount Sinai Researchers Identify Gene Mutations in Congenital Heart Disease
2. Researchers take important step in unlocking what causes congenital heart disease
3. Pets a Boon for the Human Heart, Cardiologists Say
4. iPads Could Affect Implanted Heart Devices, Early Study Finds
5. Everyday Noise Levels May Affect the Heart
6. Swimming Pools May Pose Hazard for People With Heart Devices
7. Fish Oil Supplements Dont Protect Against Heart Trouble: Study
8. WomenHeart Wins “Full Circle Award” at the 4th M2W®-HW™ - The Marketing Health & Wellness to Women Conference
9. Docs Should Ask Heart Patients About Quality of Life
10. Heart Attack Preventing Drug, Plavix, Poses Continued Risk While Bristol-Myers Squibb Extends the Rights to Others for Generic OTC Versions
11. Duke scientists build a living patch for damaged hearts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Many Heart Defects Aren't Inherited, Study Finds
(Date:9/22/2017)... HOUSTON, Texas (PRWEB) , ... September 22, 2017 ... ... leading network of independent freestanding emergency rooms is celebrating the one year anniversary ... anniversary of our facility opening,” said Dr. Otinwa, Facility Medical Director of First ...
(Date:9/22/2017)... ... September 22, 2017 , ... Silicon ... effectively even on the go. Their electric toothbrushes aggressively attack oral bacteria by ... UV sanitizing technology. Combining leading edge Enke technology with a premium timeless design, ...
(Date:9/22/2017)... ... ... “Letters From Home”: a moving compilation of letters that remind readers of ... Home” is the creation of published author, John Allred, a passionate leader of ministry ... International, who has traveled and ministered on four continents. , “It is my hope ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... create life. Although frozen embryos have a slight statistical advantage for live births, ... is a wonderful opportunity for women undergoing medical treatment or who are concerned ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... With ProSlideshow ... fun and easy to do. Users can select from up to two layers of ... a click of a mouse all within Final Cut Pro X. , ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed ...   ... Jim Bertolina, ... Tom Tefft ... medical device executive Josh Stopek , PhD, who has led R&D and business development ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
(Date:9/13/2017)... 2017   OrthoAtlanta has been named the official ... Committee (AFHC) for the 2018 College Football Playoff (CFP) National ... Mercedes-Benz Stadium in Atlanta, Georgia . OrthoAtlanta ... In" campaign, participating in many activities leading up to, and ... ...
Breaking Medicine Technology: