Navigation Links
Many Heart Defects Aren't Inherited, Study Finds
Date:5/13/2013

SUNDAY, May 12 (HealthDay News) -- At least 10 percent of severe genetic heart defects are caused by new gene mutations that were not passed down from patients' parents, a new study finds.

Congenital heart disease is the most common form of birth defect and occurs in nearly 1 percent of newborns.

"These findings provide new insight into the causes of this common congenital disease," senior study author Richard Lifton, chair of the genetics department at the Yale School of Medicine, said in a university news release.

Lifton's tream analyzed the genes of more than 1,800 people and identified hundreds of mutations that can cause congenital heart disease. In particular, the investigators found that frequent mutations occurred in genes that affect what's known as histones. Histones are proteins that package DNA in the cell's nucleus and control the timing and activation of genes that may be key to fetal development.

The study was published online May 12 in the journal Nature.

"Most interestingly, the set of genes mutated in congenital heart disease unexpectedly overlapped with genes and pathways mutated in autism," Lifton said. "These findings suggest there may be common pathways that underlie a wide range of common congenital diseases."

"This is an important piece of the puzzle that gives us a clearer picture of the causes of congenital heart disease," Dr. Gary Gibbons, director of the U.S. National Heart, Lung, and Blood Institute, added in the news release. The institute funded the study.

More information

The March of Dimes has more about congenital heart defects.

-- Robert Preidt

SOURCE: Yale University, news release, May 12, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Mount Sinai Researchers Identify Gene Mutations in Congenital Heart Disease
2. Researchers take important step in unlocking what causes congenital heart disease
3. Pets a Boon for the Human Heart, Cardiologists Say
4. iPads Could Affect Implanted Heart Devices, Early Study Finds
5. Everyday Noise Levels May Affect the Heart
6. Swimming Pools May Pose Hazard for People With Heart Devices
7. Fish Oil Supplements Dont Protect Against Heart Trouble: Study
8. WomenHeart Wins “Full Circle Award” at the 4th M2W®-HW™ - The Marketing Health & Wellness to Women Conference
9. Docs Should Ask Heart Patients About Quality of Life
10. Heart Attack Preventing Drug, Plavix, Poses Continued Risk While Bristol-Myers Squibb Extends the Rights to Others for Generic OTC Versions
11. Duke scientists build a living patch for damaged hearts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Many Heart Defects Aren't Inherited, Study Finds
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
(Date:6/23/2016)... Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new ... affiliate in Latin America . ... ... ... ...
Breaking Medicine Technology: