Navigation Links
Many HIV Patients Carry Strain With Drug-Resistant Mutation
Date:2/28/2011

MONDAY, Feb. 28 (HealthDay News) -- A new study estimates that between 10 percent and 15 percent of HIV patients in Europe and the United States are infected with a form of HIV that already has at least one drug-resistant mutation.

The researchers found that the risk of treatment failure in these patients is three times higher than normal, and said their findings confirm the need for drug resistance testing in new patients to determine which antiretroviral drugs are most likely to be successful.

For the study, 10,056 HIV patients who were beginning combination antiretroviral therapy (cART) for the first time were categorized into three resistance categories: 90.5 percent (9,102 patients) had no transmitted drug-resistance (TDR); 4.7 percent (475 patients) had at least one mutation and were receiving fully active cART; 4.8 percent (479 patients) had at least one mutation and were resistant to at least one prescribed drug.

Compared to patients without TDR, those with TDR and resistance to at least one prescribed drug were more than three times as likely to experience treatment failure, confirming "the need for at least three fully active antiretroviral drugs to optimize the virological response to a first-line regimen," the researchers wrote.

But the risk of treatment failure was not significantly different between patients without TDR and those with TDR taking a fully active cART regimen containing drugs not compromised by resistance.

The researchers also found that treatment failure was higher among patients with TDR who were taking two nucleotide reverse transcriptase inhibitors (NRTIs) plus one non-nucleotide reverse transcriptase inhibitor (NNRTI) and were predicted to be on a fully active treatment, compared to patients on protease inhibitor-based regimens whose risk of treatment failure was similar to patients with no TDR.

"If drug-resistant mutations are detected before treatment initiation, a ritonavir-boosted protease inhibitor can be included in the first treatment regimen, which, because of its higher genetic barrier, could better protect from the risk of virological failure than could NNRTI," Dr. Linda Wittkop, of INSERM, University Bordeaux Segalen in Bordeaux, France, and colleagues wrote.

"These findings confirm present treatment guidelines for HIV, which state that the initial treatment choice should be based on resistance testing in treatment-naive patients," they concluded.

The study is published in the Feb. 28 online edition of The Lancet Infectious Diseases.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV treatment.

-- Robert Preidt

SOURCE: The Lancet Infectious Diseases, news release, Feb. 27, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Doctors Can Influence Patients to Lose Weight: Studies
2. Heart Patients With Depression Often Find ER Delays
3. Experts call for greater pain assessment in hospitals as 65 percent of patients report problems
4. Fish Oil Seems to Help Cancer Patients Preserve Muscle
5. Standard Exams Might Not Catch Full Potential of Brain Damaged Patients
6. New way to identify patients at risk of dysphagia after head and neck cancer treatment
7. Type 1 Diabetes Patients Need New Kidney Therapies: Study
8. Many Dialysis Patients at Risk for High Radiation Exposure
9. Statins Might Help HIV Patients, Study Suggests
10. Most locked-in syndrome patients say they are happy
11. Lack of health insurance limits hepatitis C patients access to latest antiviral therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Many HIV Patients Carry Strain With Drug-Resistant Mutation
(Date:3/24/2017)... ... 2017 , ... “Finding Christ Through Social Media: Year One ... the writer’s path toward true communion with God. “Finding Christ Through Social Media: ... creation of published author Lea Michelle Johnson, a follower of Christ, wife and ...
(Date:3/23/2017)... ... 2017 , ... In 2016 the World Health Organization declared the Zika virus ... Zika-related cases in the Americas within the next year. Lyme disease is one of ... skyrocketing to an estimated 329,000. Yet, Zika, Lyme and other insect borne illnesses are ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... Oklahoma City Convention Center at 10 North Broadway Avenue, will be an educational ... of relevant, practical instruction in the management of chronic pain. , Oklahoma is ...
(Date:3/23/2017)... , ... March 23, 2017 , ... March is National ... pack a punch when it comes to maintaining good health. Every day, two kidneys ... your kidneys filter every drop of your blood, eliminating waste, regulating fluid levels and ...
(Date:3/23/2017)... AZ (PRWEB) , ... March 23, 2017 , ... The ... people around the world to manage stress and anxiety. , “Buzzies change the ... neuropsychologist, inventor and co-founder of Buzzies. , Since its launch date in December 2016, ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... and GENEVA , March ... on World Tuberculosis Day revitalizes efforts to develop sutezolid ... On World Tuberculosis Day, TB Alliance and the ... the clinical development of sutezolid, an antibiotic drug candidate ... pertains to the development of sutezolid in combination with ...
(Date:3/23/2017)... DUBLIN , Mar. 23, 2017 Research ... Valve Devices Market: Analysis By Procedure, Replacement Procedure By Technique, Repair ... their offering. ... Global Heart Valve Devices Market is forecasted to grow at a ... heart valve devices is driven by rising aging population, growth in ...
(Date:3/23/2017)... , March 23, 2017  The U.S. Food and ... for the treatment of adults and pediatric patients 12 ... including those who have not received prior chemotherapy. This ... rare, aggressive form of skin cancer. "While ... patients with a rare form called Merkel cell cancer ...
Breaking Medicine Technology: