Navigation Links
Many HIV Patients Carry Strain With Drug-Resistant Mutation
Date:2/28/2011

MONDAY, Feb. 28 (HealthDay News) -- A new study estimates that between 10 percent and 15 percent of HIV patients in Europe and the United States are infected with a form of HIV that already has at least one drug-resistant mutation.

The researchers found that the risk of treatment failure in these patients is three times higher than normal, and said their findings confirm the need for drug resistance testing in new patients to determine which antiretroviral drugs are most likely to be successful.

For the study, 10,056 HIV patients who were beginning combination antiretroviral therapy (cART) for the first time were categorized into three resistance categories: 90.5 percent (9,102 patients) had no transmitted drug-resistance (TDR); 4.7 percent (475 patients) had at least one mutation and were receiving fully active cART; 4.8 percent (479 patients) had at least one mutation and were resistant to at least one prescribed drug.

Compared to patients without TDR, those with TDR and resistance to at least one prescribed drug were more than three times as likely to experience treatment failure, confirming "the need for at least three fully active antiretroviral drugs to optimize the virological response to a first-line regimen," the researchers wrote.

But the risk of treatment failure was not significantly different between patients without TDR and those with TDR taking a fully active cART regimen containing drugs not compromised by resistance.

The researchers also found that treatment failure was higher among patients with TDR who were taking two nucleotide reverse transcriptase inhibitors (NRTIs) plus one non-nucleotide reverse transcriptase inhibitor (NNRTI) and were predicted to be on a fully active treatment, compared to patients on protease inhibitor-based regimens whose risk of treatment failure was similar to patients with no TDR.

"If drug-resistant mutations are detected before treatment initiation, a ritonavir-boosted protease inhibitor can be included in the first treatment regimen, which, because of its higher genetic barrier, could better protect from the risk of virological failure than could NNRTI," Dr. Linda Wittkop, of INSERM, University Bordeaux Segalen in Bordeaux, France, and colleagues wrote.

"These findings confirm present treatment guidelines for HIV, which state that the initial treatment choice should be based on resistance testing in treatment-naive patients," they concluded.

The study is published in the Feb. 28 online edition of The Lancet Infectious Diseases.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV treatment.

-- Robert Preidt

SOURCE: The Lancet Infectious Diseases, news release, Feb. 27, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Doctors Can Influence Patients to Lose Weight: Studies
2. Heart Patients With Depression Often Find ER Delays
3. Experts call for greater pain assessment in hospitals as 65 percent of patients report problems
4. Fish Oil Seems to Help Cancer Patients Preserve Muscle
5. Standard Exams Might Not Catch Full Potential of Brain Damaged Patients
6. New way to identify patients at risk of dysphagia after head and neck cancer treatment
7. Type 1 Diabetes Patients Need New Kidney Therapies: Study
8. Many Dialysis Patients at Risk for High Radiation Exposure
9. Statins Might Help HIV Patients, Study Suggests
10. Most locked-in syndrome patients say they are happy
11. Lack of health insurance limits hepatitis C patients access to latest antiviral therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Many HIV Patients Carry Strain With Drug-Resistant Mutation
(Date:10/13/2017)... PITTSBURGH, Pa. (PRWEB) , ... October 13, 2017 , ... ... the dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a ... access to medication in darkness or restricted lighting. As such, it eliminates the need ...
(Date:10/13/2017)... ... , ... Lori R. Somekh, founder of the Law Office of Somekh ... law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up ... network with elder law attorneys nationwide,” said Somekh. , ElderCounsel was ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th ... Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, ... The fun run is geared towards children of all ages; it is a non-competitive, ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/22/2017)... SAN DIEGO , Sept. 22, 2017 ... ll medical device is now successfully helping those with ... Union. Fibromyalgia diagnosed Amanda in ... getting dressed and washing my hair, experiencing no sleep ... body in painful spasm… I cannot recommend [the AVACEN ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: