Navigation Links
Many HIV Patients Carry Strain With Drug-Resistant Mutation
Date:2/28/2011

MONDAY, Feb. 28 (HealthDay News) -- A new study estimates that between 10 percent and 15 percent of HIV patients in Europe and the United States are infected with a form of HIV that already has at least one drug-resistant mutation.

The researchers found that the risk of treatment failure in these patients is three times higher than normal, and said their findings confirm the need for drug resistance testing in new patients to determine which antiretroviral drugs are most likely to be successful.

For the study, 10,056 HIV patients who were beginning combination antiretroviral therapy (cART) for the first time were categorized into three resistance categories: 90.5 percent (9,102 patients) had no transmitted drug-resistance (TDR); 4.7 percent (475 patients) had at least one mutation and were receiving fully active cART; 4.8 percent (479 patients) had at least one mutation and were resistant to at least one prescribed drug.

Compared to patients without TDR, those with TDR and resistance to at least one prescribed drug were more than three times as likely to experience treatment failure, confirming "the need for at least three fully active antiretroviral drugs to optimize the virological response to a first-line regimen," the researchers wrote.

But the risk of treatment failure was not significantly different between patients without TDR and those with TDR taking a fully active cART regimen containing drugs not compromised by resistance.

The researchers also found that treatment failure was higher among patients with TDR who were taking two nucleotide reverse transcriptase inhibitors (NRTIs) plus one non-nucleotide reverse transcriptase inhibitor (NNRTI) and were predicted to be on a fully active treatment, compared to patients on protease inhibitor-based regimens whose risk of treatment failure was similar to patients with no TDR.

"If drug-resistant mutations are detected before treatment initiation, a ritonavir-boosted protease inhibitor can be included in the first treatment regimen, which, because of its higher genetic barrier, could better protect from the risk of virological failure than could NNRTI," Dr. Linda Wittkop, of INSERM, University Bordeaux Segalen in Bordeaux, France, and colleagues wrote.

"These findings confirm present treatment guidelines for HIV, which state that the initial treatment choice should be based on resistance testing in treatment-naive patients," they concluded.

The study is published in the Feb. 28 online edition of The Lancet Infectious Diseases.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV treatment.

-- Robert Preidt

SOURCE: The Lancet Infectious Diseases, news release, Feb. 27, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Doctors Can Influence Patients to Lose Weight: Studies
2. Heart Patients With Depression Often Find ER Delays
3. Experts call for greater pain assessment in hospitals as 65 percent of patients report problems
4. Fish Oil Seems to Help Cancer Patients Preserve Muscle
5. Standard Exams Might Not Catch Full Potential of Brain Damaged Patients
6. New way to identify patients at risk of dysphagia after head and neck cancer treatment
7. Type 1 Diabetes Patients Need New Kidney Therapies: Study
8. Many Dialysis Patients at Risk for High Radiation Exposure
9. Statins Might Help HIV Patients, Study Suggests
10. Most locked-in syndrome patients say they are happy
11. Lack of health insurance limits hepatitis C patients access to latest antiviral therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Many HIV Patients Carry Strain With Drug-Resistant Mutation
(Date:1/18/2017)... ... January 18, 2017 , ... Park ... financial planning services to families and business owners in the greater Kansas City ... children with developmental disabilities. , The Lakemary Center is a comprehensive educational resource ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... communications company, launched a new website for its Center for Biosimilars, announced Michael ... include the latest developments in the field of biosimilars through thought leader interaction ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... Floundering on ... Heart Month and the perfect time for a reset. The U.S. Apple Association agrees ... to combat many of the factors that contribute to heart disease. , The U.S. ...
(Date:1/17/2017)... ... January 17, 2017 , ... In the crowded Ath-leisure market, ... stand-out company for several differences from other mainstream brands. , Firstly, in ... is called 'Agile' manufacturing - http://www.leanproduction.com/agile-manufacturing.html . It allows them to have ...
(Date:1/17/2017)... ... 2017 , ... SunView Software’s Service Smart Technology has been selected as a ... , Each year, Pink Elephant recognizes a new product or service developed by an ... problem or opportunity. The award highlights original innovations that were released in 2016, either ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... and KANSAS CITY, Mo. ... Neonatal Consortium (CHNC) has selected Velos and its ... data management and multicenter initiatives. CHNC ... of 32 Neonatal Intensive Care Units at leading ... . The consortium provides a benchmark of care ...
(Date:1/17/2017)... Following an initial analysis, the Senior ... and Drug Administration,s (FDA,s) final regulatory guidance regarding ... Pharmacies and Outsourcing Facilities." In its final guidance, ... -- which would have put patients at risk ... care (LTC) pharmacies.  The agency ...
(Date:1/17/2017)... a letter to President-elect Donald J. Trump , ... priorities for Americans age 50 and older including protecting ... care coverage, and lowering the cost of prescription drugs. ... Trump that "Our nearly 38 million members nationwide and ... their Medicare and Social Security benefits, protect their access ...
Breaking Medicine Technology: