Navigation Links
Manipulating brain inflammation may help clear brain of amyloid plaques, Mayo Clinic researchers say
Date:10/22/2009

e had initiated these studies using our new in vivo model to confirm whether inducing inflammation in the brain would in fact exacerbate the disease," Dr. Das says.

The researchers used a technique known as "Somatic Brain Transgenesis" to increase expression of Interleukin-6 (IL-6), a cytokine that stimulates an inflammatory immune response in the brains of young mice predisposed to developing age-progressive amyloid plaques. This powerful technology allows researchers to express any gene of interest in specific parts of the body by tagging the gene onto Adeno-associated viruses, which are inert. In this way, they can study the function of any protein in the brain, and also test its potential therapeutic use.

They found that IL-6 triggered inflammation throughout the brain, and they expected to see a big buildup of plaque as well as damage to brain neurons. "Instead, to our surprise, we found that the inflammation prevented plaques from forming and cleared whatever plaque that was already there," Dr. Das says.

Given this unexpected result, they performed additional experiments using different strategies. "First, we expressed IL-6 in the brains of newly born mice that are yet to develop any amyloid plaques and, secondly, we expressed IL-6 in the brains of mice with pre-existing plaque pathology," he says. "In both these cases, we got similar results the presence of IL-6 leads to the clearance of amyloid plaques from the brain."

The researchers then performed experiments to determine how the amyloid plaques were removed from the brain. Their analysis revealed that the inflammation induced by IL-6 in the brain directed the microglia cells to remove the amyloid plaques from the brain. Microglial cells do this by phagocytosis. "They gobble up the plaque, which they 'see' as a foreign invader, and break it apart," Dr. Das says. Researchers also found that activated microglia cells were closely attached to the plaques and expressed pro
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Manipulating Key Protein May Prevent Eczema
2. Manipulating the immune system like a parasite
3. Brain Protein Tied to Retardation
4. The Brain Comes Alive With the Sounds of Music
5. If Hearing Loss is Not Treated, Brain Can Forget How to Hear and Understand Speech
6. More research needed on blast induced traumatic brain injury and vestibular pathology
7. Brain Yields Up Clues to Language
8. VCU Medical Center Surgeons Use Deep Brain Stimulation to Treat Movement Disorder Caused by Rare Pediatric Condition
9. Study Suggests Link Between Cell Phones and Brain Tumors
10. New Brain Stimulation Treatment May Offer Hope For Those With Treatment Resistant Depression
11. New brain stimulation treatment may offer hope for those with treatment resistant depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... 25, 2014 More than 50 Family ... Reception on Monday at the home of Jim and ... from guest speaker Dr. Winifred Lender on finding the ... Lender, a Santa Barbara psychologist, author and Noozhawk columnist, ... of living in the digital age. Our digital reality ...
(Date:10/25/2014)... Wisconsin (PRWEB) October 25, 2014 QueenBeeTickets.com ... for a great selection at affordable prices. Bob Seger ... Center Huntington Center and Nationwide Arena are going on ... , Click Here to browse the selection ... Band at QueenBeeTickets.com. , The famous singer is touring ...
(Date:10/25/2014)... supply to an arm or a leg before heart surgery ... to a new study. "During heart surgery we ... be able to operate on it. After some time without ... energy because it doesn,t get oxygen. When we shut off ... arm or a leg, the body prepares for an upcoming ...
(Date:10/25/2014)... 23, 2014 (HealthDay News) -- Current osteoporosis screening ... postmenopausal women at risk for osteoporosis-related fractures, a ... prevent fractures, we need tools that help us ... so that we can target these at-risk people ... professor of medicine in the division of general ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 On October ... Minds featuring skin diseases both fictional and real. ... (CEHMDF), a nonprofit organization committed to advocacy and philanthropy ... CBS will take the opportunity to impart truth and ... , There are many misconceptions about Morgellons ...
Breaking Medicine News(10 mins):Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 2Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 4Health News:QueenBeeTickets.com Features Bob Seger & The Silver Bullet Band Tickets for Charleston Civic Center, Huntington Center, and Nationwide Arena at Reduced Prices 2Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3
... International AIDS Society (IAS), conveners of the International AIDS ... People Living with HIV (GNP+), the International Council of ... with HIV/AIDS (ICW) and the United Nations Joint Programme ... civil society and local partners for the XIX International ...
... the effectiveness of a broad selection of popular slimming ... found no evidence that any of them facilitate weight ... today (Monday) at the International Congress on Obesity in ... than the fake supplements they were compared with. ...
... of nearly 150 randomized controlled trials on children all ... 60 percent of the studies either failed to take steps ... describe those measures. A report of the team,s findings ... experimental trials sponsored by pharmaceutical or medical-device makers, along with ...
... HealthDay Reporter , FRIDAY, July 9 (HealthDay News) -- ... the United States in recent years, are exposing patients to ... of its kind. , , But experts really don,t know ... long-term effects will be, according to new research published online ...
... 9, 2010) -- At the 52nd meeting of the ... from July 18 - 22, 2010 in Philadelphia, PA, ... to share the latest developments in medical imaging and ... discuss many of the ethical and regulatory issues that ...
... , FRIDAY, July 9 (HealthDay News) -- Researchers report ... addiction in rats and may have the same effect in ... of the journal Nature , are preliminary, but they ... of anti-addiction medications," said study senior author Paul J. Kenny, ...
Cached Medicine News:Health News:Civil society and local partners for XIX International AIDS Conference (AIDS 2012) announced 2Health News:Civil society and local partners for XIX International AIDS Conference (AIDS 2012) announced 3Health News:New research finds no evidence that popular slimming supplements facilitate weight loss 2Health News:New research finds no evidence that popular slimming supplements facilitate weight loss 3Health News:Pediatric clinical studies appear prone to bias, Hopkins review shows 2Health News:Pediatric clinical studies appear prone to bias, Hopkins review shows 3Health News:Cumulative Radiation Doses Seen in Cardiac Imaging 2Health News:Cumulative Radiation Doses Seen in Cardiac Imaging 3Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 2Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 3Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 4Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 5Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 6Health News:Rat Study Sheds Light on Cocaine Addiction 2
(Date:10/22/2014)... 21, 2014   BioNano Genomics , the ... research centers to purchase an Irys™ System . ... Cancer Institute (NCI), NIH Intramural Sequencing Center (NISC) and ... obtaining a comprehensive view of a genome was ... does not deliver the scalability or reliability to ...
(Date:10/22/2014)... ANAHEIM, Calif. , Oct. 21, 2014 Influenza ... with flu-associated deaths in the United States ... influenza viruses are thought to spread is from person to ... Ebola has a serve way of death, but kills ... of Ebola is also done by human fluids including sweat, ...
(Date:10/22/2014)... 22, 2014 Sanomedics International Holdings, Inc. (OTCQB: ... Global Research & Data Services, demand for thermometers is ... through 2018, as demand for more accurate digital thermometers ... the world,s largest market for thermometers, and one of ... Sanomedics International Holdings, Inc. Sanomedics International Holdings ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2
TG (Ab) RIA Thyroid Function 014-HD 27.1 Thyroglobulin...
Free T4 EIA Thyroid Function 025-BC-1008...
... immunoassay (EIA) test kit is to be ... estriol in human serum during the second ... is an enzyme immunoassay, which is based ... procedure, estriol is conjugated to the enzyme,horseradish ...
... The procedure follows the basic principle of ... competition between an unlabeled antigen and an ... sites of a specific antiserum . The ... estrone) bound to the antibody is inversely ...
Medicine Products: