Navigation Links
Manipulating Key Protein May Prevent Eczema
Date:12/17/2008

Study might lead to new treatments for itchy skin condition

WEDNESDAY, Dec. 17 (HealthDay News) -- The discovery of a protein that seems to contribute to the development of eczema may one day lead to preventive treatments for the itchy and often painful skin condition -- at least if new research with mice applies to people.

For the study, researchers worked with two groups of mice -- one that had a receptor for the protein called IL-21, and one that did not. Both groups were shaved and their skin irritated using sticky tape to mimic the effect that scratching or damaging the skin would have in humans. In humans prone to eczema, this type of irritation would likely lead to an aggravated immune response and a worsening of eczema.

Researchers found that the presence of IL-21 was essential to the inflammation characteristic of eczema.

"We used mice that were genetically deficient in the receptor for IL-21 and these mice did not develop the disease, so the receptor is one of the critical factors for the development of eczema," said study author Dr. Raif Geha, chief of the children's division of allergy/immunology at Children's Hospital Boston and Harvard Medical School.

Geha and his colleagues found that even mice with IL-21 receptors could be spared from developing eczema by pumping them with a decoy receptor to fool their immune system and keep it from attacking the inflamed area. The finding offers further evidence that IL-21 is important in the formation of the disease and could point the way to future treatments, he said.

But, Geha added, much more research with animals is needed before the approach could be tried with people.

"One limitation is that while the mice didn't develop any side effects, we don't know if the same strategy would have side effects in humans," he said. "The other limitation is that we don't know if the agent will work after the eczema sets in."

Geha said future treatments might target individuals prone to eczema before they begin to show symptoms, but, again, much research remains to be done.

The study findings were published in the December issue of the Journal of Clinical Investigation.

More information

To learn more about eczema, visit the U.S. National Library of Medicine.



SOURCES: Raif Geha, M.D., the James Gamble Professor of Pediatrics, Harvard Medical School, and chief, children's division of allergy/immunology, Children's Hospital, Boston; December 2008 Journal of Clinical Investigation


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Manipulating the immune system like a parasite
2. Draining away brains toxic protein to stop Alzheimers
3. Penn study finds pro-death proteins required to regulate healthy immune function
4. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
5. Emory researchers identify signaling protein for multiple myeloma
6. Human C-reactive protein regulates myeloma tumor cell growth and survival
7. Lowering Blood Protein Wont Help Kidney Patients
8. Blood protein detects lung cancer, even at earliest stage
9. Natural Protein Could Help Spot, Treat Liver Cancer
10. Heat shock proteins are co-opted for cancer
11. How adhesive protein causes malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... Utah (PRWEB) , ... April 21, 2017 , ... ... wilderness therapy treatment for adolescents and young adults, has kicked off its 4th ... April 23rd. This year’s theme is “Attachment Informed Therapy for Mental Health ...
(Date:4/21/2017)... ... 21, 2017 , ... The Patient Advocacy Community of The Beryl Institute presented ... Ruth Ravich Patient Advocacy Award in recognition of her extraordinary contributions to the ... award at The Beryl Institute’s annual Patient Experience Conference on March 20 ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Alive ... people who wish to overcome their mental health struggles. The Alive team uses ... LeBouthillier says: “Our approach in dealing with a mental health struggle is based on ...
(Date:4/21/2017)... ... ... Providing for loved ones before one’s passing is of paramount importance. However, ... “Now more than ever there are some questions that are far too critical to ... attorney Lisa Edgar Dickman, founder of the Law Offices of Lisa Edgar Dickman. ...
(Date:4/21/2017)... ... ... During April 21-23, Super-Sod will join the vendor market of the Sacred ... — from the avid gardener to the landscape admirer — during the three-day schedule. ... a grand venue, and we are certainly looking forward to participating in this year’s ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... April 20, 2017   ZappRx, Inc ., a digital ... prescribing process, today announced it closed $25 million in Series ... capital firm based in Seattle that ... Partners . The Series B round included participation from ... 2014, and GV (formerly Google Ventures). As part ...
(Date:4/20/2017)... -- Eyevensys, a private biotechnology company developing ... technology that enables the safe, local, sustained production of ... range of ophthalmic diseases, announces it has received approval ... (MHRA) to advance its technology into clinical development. ... The EyeCET platform ...
(Date:4/19/2017)... April 19, 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) ... & Co. Healthcare Investor Conference 2017 at the Sheraton Hotel in ... , Chief Executive Officer of the Company is scheduled to present ... Richard Bear and the Chairman of the Board, Tony ... ...
Breaking Medicine Technology: