Navigation Links
Manipulating Key Protein May Prevent Eczema
Date:12/17/2008

Study might lead to new treatments for itchy skin condition

WEDNESDAY, Dec. 17 (HealthDay News) -- The discovery of a protein that seems to contribute to the development of eczema may one day lead to preventive treatments for the itchy and often painful skin condition -- at least if new research with mice applies to people.

For the study, researchers worked with two groups of mice -- one that had a receptor for the protein called IL-21, and one that did not. Both groups were shaved and their skin irritated using sticky tape to mimic the effect that scratching or damaging the skin would have in humans. In humans prone to eczema, this type of irritation would likely lead to an aggravated immune response and a worsening of eczema.

Researchers found that the presence of IL-21 was essential to the inflammation characteristic of eczema.

"We used mice that were genetically deficient in the receptor for IL-21 and these mice did not develop the disease, so the receptor is one of the critical factors for the development of eczema," said study author Dr. Raif Geha, chief of the children's division of allergy/immunology at Children's Hospital Boston and Harvard Medical School.

Geha and his colleagues found that even mice with IL-21 receptors could be spared from developing eczema by pumping them with a decoy receptor to fool their immune system and keep it from attacking the inflamed area. The finding offers further evidence that IL-21 is important in the formation of the disease and could point the way to future treatments, he said.

But, Geha added, much more research with animals is needed before the approach could be tried with people.

"One limitation is that while the mice didn't develop any side effects, we don't know if the same strategy would have side effects in humans," he said. "The other limitation is that we don't know if the agent will work after the eczema sets in."

'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Manipulating the immune system like a parasite
2. Draining away brains toxic protein to stop Alzheimers
3. Penn study finds pro-death proteins required to regulate healthy immune function
4. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
5. Emory researchers identify signaling protein for multiple myeloma
6. Human C-reactive protein regulates myeloma tumor cell growth and survival
7. Lowering Blood Protein Wont Help Kidney Patients
8. Blood protein detects lung cancer, even at earliest stage
9. Natural Protein Could Help Spot, Treat Liver Cancer
10. Heat shock proteins are co-opted for cancer
11. How adhesive protein causes malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... , ... August 27, 2015 , ... Mesa Community ... than 2,100 applicants worldwide, selected based on academic rigor, leadership and engagement, to receive ... a baccalaureate degree. , Sypher will receive a medallion and a $7,500 scholarship to ...
(Date:8/27/2015)... Billings, Montana (PRWEB) , ... August 27, 2015 ... ... Disorders Association, the average annual cost to treat a patient with hemophilia is ... engaged in finding a cure and improving treatment. The RMHBDA exists to help ...
(Date:8/27/2015)... , ... August 27, 2015 , ... According to an ... Conference on Abdominal Wall Hernia Surgery involved many conversations between hernia experts surrounding the ... there, the article notes that many different experts have different ideas about which is ...
(Date:8/27/2015)... ... August 27, 2015 , ... In an article published July ... the city of New Orleans, highlighting a security firm that is tasked with providing ... tech oriented entrepreneur who worked with the city to provide private security when it ...
(Date:8/27/2015)... ... August 27, 2015 , ... Allegheny General Hospital (AGH), part ... medical centers in the United States to receive international recognition for an advanced, ... Extracorporeal Life Support Organization (ELSO) , an international consortium of healthcare institutions dedicated ...
Breaking Medicine News(10 mins):Health News:Mesa Community College Graduate Andrew Sypher Receives Hites Transfer Scholarship 2Health News:Mesa Community College Graduate Andrew Sypher Receives Hites Transfer Scholarship 3Health News:Avitus Group Encourages Business & Employee Community Involvement; Senior Level Staff Leads Way With Support of Rocky Mountain Hemophilia & Bleeding Disorders Association 2Health News:Avitus Group Encourages Business & Employee Community Involvement; Senior Level Staff Leads Way With Support of Rocky Mountain Hemophilia & Bleeding Disorders Association 3Health News:Avitus Group Encourages Business & Employee Community Involvement; Senior Level Staff Leads Way With Support of Rocky Mountain Hemophilia & Bleeding Disorders Association 4Health News:Recent Article on Hernia Mesh Developments Highlights Viable Options, But Shows a Need for Further Research, notes Dr. Shirin Towfigh 2Health News:Article on New Orleans Security Force Highlights the Abilities and Flexibility of Private Security, says Spear Security Inc. 2Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 2Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 3Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 4
... Flomax Is Case Study of How Costly Drugs Drive Up ... According to a new report by Consumer Reports Best Buy ... widely advertised drug Flomax for treating the symptoms of enlarged prostate, and ... the 20 most commonly prescribed drugs in 2008. , ...
... 15 AMDL Inc. (NYSE ... China, announced today the second closing of a private placement offering ... The exclusive placement agent for the offering is Cantone Research ... 2009, AMDL sold $1,327,250 of 12% Series 2 convertible notes at ...
... gives a talk about his research, he begins with the ... supermodel died from severe sepsis in January after amputation of ... Martin, who is a fellow in allergy, pulmonary and ... Vanderbilt University that has come up with a high-tech approach ...
... yeast rice does well in small trial, but there are ... new study revives a running controversy about the purported cholesterol-lowering ... , Red yeast rice is produced when a yeast, ... used in Asian countries for more than a thousand years ...
... infections, heart problems, new advisory says , MONDAY, ... undergoing surgery are at greater risk of heart ... complications, according to a Scientific Advisory from the ... anesthesiologists and other health-care providers underestimate the seriousness ...
... This release is available in French . ... (BWF) has announced the recipients of the 2009 Investigators in ... Saleh was one of six recipients granted $500,000 over a ... of NLR-mediated innate immunity." "We are studying how the body ...
Cached Medicine News:Health News:Consumer Reports 'Best Buy Drug' for Enlarged Prostate Could Save Consumers Nearly $3,000 a Year 2Health News:Consumer Reports 'Best Buy Drug' for Enlarged Prostate Could Save Consumers Nearly $3,000 a Year 3Health News:Consumer Reports 'Best Buy Drug' for Enlarged Prostate Could Save Consumers Nearly $3,000 a Year 4Health News:AMDL Inc. Announces Second Closing of Private Placement of Series 2 Senior Notes 2Health News:AMDL Inc. Announces Second Closing of Private Placement of Series 2 Senior Notes 3Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 2Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 3Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 4Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 5Health News:A Substitute for Those Who Can't Take Statins? 2Health News:A Substitute for Those Who Can't Take Statins? 3Health News:Heart Association Warns of Surgery Risks in Obese 2Health News:MUHC researcher awarded $500,000 to study pathogenesis of infectious disease 2
(Date:8/27/2015)... Md. , Aug. 27, 2015  BioElectronics Corporation (OTC ... announced today that three abstracts featuring the use of ... at the 9 th Congress of the European ... 2-5 th September 2015. The Company will also ... Dr Gianluca Bagnato , department clinical and ...
(Date:8/27/2015)... 27, 2015  PinnacleHealth CardioVascular Institute enrolled the first patient ... the United States in a trial assessing ... for blockages in the main artery of the leg. The ... potentially less risk for stent fracture or re-narrowing after the ... multicenter clinical trial of the BioMimics 3D Stent System and ...
(Date:8/27/2015)... , Aug. 27, 2015   Americord Registry ... tissue , and placenta tissue banking company, ... blood banking e-commerce website. This new website makes the ... with an interactive shopping cart and checkout process. ... "Most cord blood banking websites make this service difficult ...
Breaking Medicine Technology:BioElectronics Selected to Present its Pain Research and Devices at the European Pain Federation Conference 2First Pennsylvania Patient Treated in Landmark Vascular Study 2Cord Blood Bank Revolutionizes Process of Online Cord Blood Banking 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: