Navigation Links
Manchester team wins $1.9 million grant for 'cell control' study

A team investigating how genes respond to hormonal changes and inflammation has been awarded a Wellcome Trust grant of 1.24 million for a five-year study.

The research programme at the National Institute for Health Research's Manchester Biomedical Research Centre (BRC) is led by Professor Julian Davis, a consultant endocrinologist at Manchester Royal Infirmary and leader of The University of Manchester's Developmental Biomedicine Research Group.

He is working with Professor Mike White, who recently joined the University's Faculty of Life Sciences from Liverpool University. Also part of the team is Professor David Rand from the Department of Mathematics at the University of Warwick.

"The aim of the study is to learn more about how tissues control themselves and influence how the body reacts to changes such as puberty or external challenges such as inflammation," explained Professor Davis.

"In previous research we discovered that the activation of genes inside cells is much more dynamic and unstable than we thought, and we now want to look at how particular cells respond in different situations."

The team will study how the body produces an important hormone, prolactin, which is one of many hormones made by the pituitary gland in the brain.

Tumours in the pituitary gland are frequent causes of excessive prolactin and can lead to infertility.

Prolactin is also produced by various other tissues including immune cells, and is thought to be involved in the body's inflammatory response.

"By understanding how the prolactin gene is controlled in individual cells, and how that is influenced by the organisation of cells into tissues, we can understand better how the pituitary gland works, and ultimately how we might develop new treatments for pituitary tumours," said Professor Davis.

"We also hope to learn more about how these hormones are first produced as the pituitary gland develops before birth.

"Using the latest cell imaging techniques, we will measure the amount of light produced by prolactin-producing pituitary and immune cells.

"We aim to create mathematical models to understand how different cells within tissues may become co-ordinated, during embryonic development and during hormonal changes such as pregnancy.

"Studying these patterns will give us new insight into the way cells react to their environment, and in the long term should help with the development of better treatments."


Contact: Kate Henry
University of Manchester

Related medicine news :

1. Amway One by One Campaign for Children Reaches 7 Million Kids
2. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
3. International Diabetes Federation awards $2 million to 9 global diabetes research projects
4. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
5. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
6. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
7. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
8. New Report: $1 Cigarette Tax Increase Would Raise $113.9 Million for Colorado and Cut Youth Smoking
9. New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking
10. Kaiser Permanente Approves $170 Million in Community Benefit Grants in 2009
11. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... Sikka Software announced today ... Meeting. Their Ecosystem empowers dentists to make complex business decisions by providing the tools ... receive a free fee survey with 10 procedures customized by zip code. , ...
(Date:11/30/2015)... ... 30, 2015 , ... Scott Newman MD, FACS of New ... plastic surgeons in the New York City area to utilize the new, non-invasive ... heat-induced laser treatment for fat loss in the abdomen, flanks, and other areas ...
(Date:11/30/2015)... Atlanta, Georgia (PRWEB) , ... November 30, 2015 ... ... training for healthcare professionals worldwide today released the results of a survey of ... Middle East and Africa found a growing global demand for high quality online ...
(Date:11/30/2015)... Miami, FL (PRWEB) , ... November 30, 2015 ... ... manufacturer and engineer of patented products, announces the Unstoppable Swappables, a household invention ... Window Coverings Industry makes $2 billion a year and is growing at 2.6%," ...
(Date:11/29/2015)... Michigan (PRWEB) , ... November 29, 2015 , ... "I ... games. Things that as a Mother and Wife would love to do, I missed. ... that I just happened to call Dr. Zaidan first. They have changed my life ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... 29, 2015   Royal Philips  (NYSE: PHG, AEX: ... at the 2015 Radiological Society of North America Annual ... Place in Chicago . Visitors to ... company,s broad portfolio of integrated Diagnostic Imaging, Clinical Informatics, ... clinical performance, improve workflow and create a superior patient ...
(Date:11/29/2015)... Nov. 29, 2015   National Decision Support Company ... client base, including notable statewide implementations. As a ... solution, ACR Select, more than 1 million times ... workflow. ACR Select provides real-time feedback on the ... and has been implemented at over 100 healthcare ...
(Date:11/27/2015)... PHILADELPHIA , Nov. 27, 2015  Lannett ... that it has completed the acquisition of Kremers ... pharmaceuticals subsidiary of global biopharmaceuticals company UCB S.A. ... --> Lannett has acquired KU from UCB ... to certain adjustments, including a customary working capital ...
Breaking Medicine Technology: