Navigation Links
Manchester team wins $1.9 million grant for 'cell control' study
Date:10/27/2010

A team investigating how genes respond to hormonal changes and inflammation has been awarded a Wellcome Trust grant of 1.24 million for a five-year study.

The research programme at the National Institute for Health Research's Manchester Biomedical Research Centre (BRC) is led by Professor Julian Davis, a consultant endocrinologist at Manchester Royal Infirmary and leader of The University of Manchester's Developmental Biomedicine Research Group.

He is working with Professor Mike White, who recently joined the University's Faculty of Life Sciences from Liverpool University. Also part of the team is Professor David Rand from the Department of Mathematics at the University of Warwick.

"The aim of the study is to learn more about how tissues control themselves and influence how the body reacts to changes such as puberty or external challenges such as inflammation," explained Professor Davis.

"In previous research we discovered that the activation of genes inside cells is much more dynamic and unstable than we thought, and we now want to look at how particular cells respond in different situations."

The team will study how the body produces an important hormone, prolactin, which is one of many hormones made by the pituitary gland in the brain.

Tumours in the pituitary gland are frequent causes of excessive prolactin and can lead to infertility.

Prolactin is also produced by various other tissues including immune cells, and is thought to be involved in the body's inflammatory response.

"By understanding how the prolactin gene is controlled in individual cells, and how that is influenced by the organisation of cells into tissues, we can understand better how the pituitary gland works, and ultimately how we might develop new treatments for pituitary tumours," said Professor Davis.

"We also hope to learn more about how these hormones are first produced as the pituitary gland develops before birth.

"Using the latest cell imaging techniques, we will measure the amount of light produced by prolactin-producing pituitary and immune cells.

"We aim to create mathematical models to understand how different cells within tissues may become co-ordinated, during embryonic development and during hormonal changes such as pregnancy.

"Studying these patterns will give us new insight into the way cells react to their environment, and in the long term should help with the development of better treatments."


'/>"/>

Contact: Kate Henry
kate.henry@cmft.nhs.uk
44-161-276-3281
University of Manchester
Source:Eurekalert

Related medicine news :

1. Amway One by One Campaign for Children Reaches 7 Million Kids
2. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
3. International Diabetes Federation awards $2 million to 9 global diabetes research projects
4. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
5. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
6. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
7. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
8. New Report: $1 Cigarette Tax Increase Would Raise $113.9 Million for Colorado and Cut Youth Smoking
9. New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking
10. Kaiser Permanente Approves $170 Million in Community Benefit Grants in 2009
11. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... Alaska (PRWEB) , ... May 22, 2017 , ... Galena, ... near the Arctic Circle made big headlines when it was targeted to build a ... Energy in Bush Alaska,” former city manager Marvin L. Yoder describes the journey to ...
(Date:5/22/2017)... ... May 22, 2017 , ... WeightZone Factor a ... WeightZone Factor members to track their exercise patterns, monitor behavioral changes, employ biometric ... on their mobile phones. It also provides social networks for members with similar ...
(Date:5/21/2017)... ... , ... Chris Cornell, 52, was found dead on the night of Wednesday, May 17, 2017. ... singers in the rock industry would take his own life, but the extremely talented and ... illness played a role in the death of Chris Cornell . , Depression and ...
(Date:5/21/2017)... ID (PRWEB) , ... May 20, 2017 , ... ... financial integration systems between ABC Financial Services and financial systems. , ... link or exported files that are electronically processed through GetLinked into their club’s ...
(Date:5/21/2017)... WINTER PARK, FL (PRWEB) , ... May 20, 2017 , ... ... now sell it, find it, review it, and share its attributes like never before. ... online dispensary directory to connect cannabis enthusiasts to stores, strains, products – and for ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... and SAN DIEGO , May ... Gynecologists (ACOG) 2017 Annual Clinical and Scientific Meeting— OBP ... illuminating medical devices, today announced the launch of a ... OfficeSPEC and ER-SPEC vaginal specula. ... of extra-small and extra-large sizes makes OBP Medical,s line ...
(Date:5/3/2017)... , May 3, 2017  Kalorama Information notes ... nine percent next year and this is projected ... hematopoietic stem cell (HSCT) or bone marrow transplants ... technologies are well-suited for this task. This according ... publisher Kalorama Information. The various PCR-based methodologies, Sanger ...
(Date:5/2/2017)...  CIVCO Radiotherapy, the leading provider of high ... Nat Geissel has been named president. ... has served as vice president of marketing and ... manager, and most recently, executive vice president and ... of what CIVCO Radiotherapy and its predecessors have ...
Breaking Medicine Technology: