Navigation Links
Manchester team wins $1.9 million grant for 'cell control' study
Date:10/27/2010

A team investigating how genes respond to hormonal changes and inflammation has been awarded a Wellcome Trust grant of 1.24 million for a five-year study.

The research programme at the National Institute for Health Research's Manchester Biomedical Research Centre (BRC) is led by Professor Julian Davis, a consultant endocrinologist at Manchester Royal Infirmary and leader of The University of Manchester's Developmental Biomedicine Research Group.

He is working with Professor Mike White, who recently joined the University's Faculty of Life Sciences from Liverpool University. Also part of the team is Professor David Rand from the Department of Mathematics at the University of Warwick.

"The aim of the study is to learn more about how tissues control themselves and influence how the body reacts to changes such as puberty or external challenges such as inflammation," explained Professor Davis.

"In previous research we discovered that the activation of genes inside cells is much more dynamic and unstable than we thought, and we now want to look at how particular cells respond in different situations."

The team will study how the body produces an important hormone, prolactin, which is one of many hormones made by the pituitary gland in the brain.

Tumours in the pituitary gland are frequent causes of excessive prolactin and can lead to infertility.

Prolactin is also produced by various other tissues including immune cells, and is thought to be involved in the body's inflammatory response.

"By understanding how the prolactin gene is controlled in individual cells, and how that is influenced by the organisation of cells into tissues, we can understand better how the pituitary gland works, and ultimately how we might develop new treatments for pituitary tumours," said Professor Davis.

"We also hope to learn more about how these hormones are first produced as the pituitary gland develops before birth.

"Using the latest cell imaging techniques, we will measure the amount of light produced by prolactin-producing pituitary and immune cells.

"We aim to create mathematical models to understand how different cells within tissues may become co-ordinated, during embryonic development and during hormonal changes such as pregnancy.

"Studying these patterns will give us new insight into the way cells react to their environment, and in the long term should help with the development of better treatments."


'/>"/>

Contact: Kate Henry
kate.henry@cmft.nhs.uk
44-161-276-3281
University of Manchester
Source:Eurekalert

Related medicine news :

1. Amway One by One Campaign for Children Reaches 7 Million Kids
2. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
3. International Diabetes Federation awards $2 million to 9 global diabetes research projects
4. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
5. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
6. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
7. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
8. New Report: $1 Cigarette Tax Increase Would Raise $113.9 Million for Colorado and Cut Youth Smoking
9. New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking
10. Kaiser Permanente Approves $170 Million in Community Benefit Grants in 2009
11. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... , ... February 08, 2016 , ... ... its newly redesigned website, federallabs.org . The site houses a wealth of ... available federal technologies through the process called technology transfer (T2). As a network ...
(Date:2/8/2016)... ... 2016 , ... Stephanie Hebert Insurance Agency, serving families of ... charity campaign. As part of their ongoing community involvement program, funds are now ... children deserve a voice, and in the spirit of neighbors helping neighbors in ...
(Date:2/8/2016)... ... February 08, 2016 , ... Brenton Engineering , ... bags, and flow wrapped products at WestPack 2015, February 9-11, in Anaheim, California. ... up to semi-automatic or fully-automatic case packing with a small footprint, rugged, highly ...
(Date:2/8/2016)... ... 08, 2016 , ... Steve Helwig & Associates Insurance & Financial, serving the ... has teamed up with Citizens Opposed to Domestic Abuse in support of its efforts ... all those victimized by the fear of violence in their own homes, donations may ...
(Date:2/8/2016)... CA (PRWEB) , ... February 08, 2016 , ... Delta ... $792,000 to help combat pancreatic cancer. , Gary D. Radine, who recently retired as ... was the American Cancer Society’s 2015 CEO of the Year , helped lead ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... -- This TforG report includes the Surgical Procedures Database ... system in South Korea . To ... provides written and numerical analysis on the current trends, ... the latest reforms of the local Healthcare system are ... The report helps businesses gain a unique insight ...
(Date:2/9/2016)... BRUNSWICK, N.J. , Feb. 9, 2016  Johnson ... the RBC Capital Markets Global Healthcare Conference on Tuesday, ... York City.  Dominic Caruso , Vice President, Finance ... Worldwide Chairman, Consumer will represent the Company in a ... www.investor.jnj.com . --> www.investor.jnj.com . ...
(Date:2/9/2016)... report "Global Anti-Bacterial Drugs Market Assessment & Forecast: 2015 - 2019" ... North America continued to lead global anti-bacterial ... into revenues worth US$ 16,907.3 million. North ... , Latin America , Middle-East ... market is inclined towards North America and ...
Breaking Medicine Technology: