Navigation Links
Manchester team wins $1.9 million grant for 'cell control' study
Date:10/27/2010

A team investigating how genes respond to hormonal changes and inflammation has been awarded a Wellcome Trust grant of 1.24 million for a five-year study.

The research programme at the National Institute for Health Research's Manchester Biomedical Research Centre (BRC) is led by Professor Julian Davis, a consultant endocrinologist at Manchester Royal Infirmary and leader of The University of Manchester's Developmental Biomedicine Research Group.

He is working with Professor Mike White, who recently joined the University's Faculty of Life Sciences from Liverpool University. Also part of the team is Professor David Rand from the Department of Mathematics at the University of Warwick.

"The aim of the study is to learn more about how tissues control themselves and influence how the body reacts to changes such as puberty or external challenges such as inflammation," explained Professor Davis.

"In previous research we discovered that the activation of genes inside cells is much more dynamic and unstable than we thought, and we now want to look at how particular cells respond in different situations."

The team will study how the body produces an important hormone, prolactin, which is one of many hormones made by the pituitary gland in the brain.

Tumours in the pituitary gland are frequent causes of excessive prolactin and can lead to infertility.

Prolactin is also produced by various other tissues including immune cells, and is thought to be involved in the body's inflammatory response.

"By understanding how the prolactin gene is controlled in individual cells, and how that is influenced by the organisation of cells into tissues, we can understand better how the pituitary gland works, and ultimately how we might develop new treatments for pituitary tumours," said Professor Davis.

"We also hope to learn more about how these hormones are first produced as the pituitary gland develops before birth.

"Using the latest cell imaging techniques, we will measure the amount of light produced by prolactin-producing pituitary and immune cells.

"We aim to create mathematical models to understand how different cells within tissues may become co-ordinated, during embryonic development and during hormonal changes such as pregnancy.

"Studying these patterns will give us new insight into the way cells react to their environment, and in the long term should help with the development of better treatments."


'/>"/>

Contact: Kate Henry
kate.henry@cmft.nhs.uk
44-161-276-3281
University of Manchester
Source:Eurekalert

Related medicine news :

1. Amway One by One Campaign for Children Reaches 7 Million Kids
2. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
3. International Diabetes Federation awards $2 million to 9 global diabetes research projects
4. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
5. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
6. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
7. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
8. New Report: $1 Cigarette Tax Increase Would Raise $113.9 Million for Colorado and Cut Youth Smoking
9. New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking
10. Kaiser Permanente Approves $170 Million in Community Benefit Grants in 2009
11. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... Louis, MS (PRWEB) , ... December 08, 2016 , ... ... that serve commercial and residential clients in and around the Hancock County area, is ... for the Hancock County Food Pantry. , The Hancock County Food Pantry has worked ...
(Date:12/8/2016)... ... December 08, 2016 , ... Bill Mull Agencies, a ... in and around central Kansas, is joining the Youth Horizons organization for a ... , Headquartered in Wichita, Youth Horizons works to empower area children from unstable, ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... will have the unique opportunity to get hands-on experience in an emergency ... students an immersive experience to gain invaluable, real-life medical skills that are critical ...
(Date:12/7/2016)... ... December 07, 2016 , ... Kenall Manufacturing, a leader in sealed healthcare lighting ... MPCNGX is a multi-function, sealed, LED luminaire that meets the needs of everyone in ... it’s needed. , A 2’ x 4’ model features four modes: reading, ...
(Date:12/7/2016)... LA (PRWEB) , ... December 07, 2016 , ... ... used to treat wrinkles and deep lines by smoothing and tightening the skin ... invasive techniques out there to address facial aging with very little downtime, Silhouette ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Research and Markets has announced the addition of the ... Application, Usability - Forecast to 2025" report to their offering. ... , , ... grow at a CAGR of around 3.2% from 2015 to 2025. ... advancements in extracellular microelectrode arrays and intracellular microelectrodes, research in left-to-right ...
(Date:12/8/2016)... 2016 Bodycad announced it has been ... accuracy, reproducibility and speed for 3D constructs via ... bone orthopaedic applications. These patents are critical to ... restorations based on each patient,s distinct anatomy. ... harnesses the world,s first suite of orthopaedic CAD/CAM ...
(Date:12/8/2016)... , Dec. 8, 2016  A new study ... that the use of opioid therapy to treat chronic ... the likelihood of more harmful consequences, including death. ... M.D., and Zankhana Mehta , M.D., authored the ... on chronic opioid therapy. The study was published in ...
Breaking Medicine Technology: