Navigation Links
Manchester researchers announce new methods of beating breast cancer
Date:10/1/2007

University of Manchester researchers will reveal new ways of controlling and treating breast cancer at the National Cancer Research Institute conference in Birmingham today (Monday 1 October 2007).

Dr Robert Clarke and his team at the University's Cancer Studies research group have been investigating human breast cancers for the presence of stem cells - cells that generate new tumours and can cause the cancer to recur - in a series of studies funded by the charity Breast Cancer Campaign.

One third of women who are successfully treated for breast cancer find that the disease recurs some years later because some of these cancer cells survive the treatment and begin to grow again.

The team's research into these 'breast cancer stem cells' revealed that the cells are stimulated by the Notch gene. The team, who published the study in Journal of the National Cancer Institute, is now hoping to develop new drug therapies to target this gene and thus stop the growth of any surviving breast cancer stem cells.

One drug that is known to attack Notch is already used for the treatment of Alzheimer's Disease so, having undergone health and safety checks, its clinical trial for use on breast cancer patients could be speeded up and lead to a treatment in hospital clinics within a few years. Herceptin, by contrast, took more than 15 years to go from the discovery of its gene target to treatment.

The team is also aiming to identify other new pathways of controlling breast cancer stem cells by using a genetic library to shut down other genes at random to see how it affects them, in a study with Rene Bernards at the Netherlands Cancer Institute.

The team, along with Professor Tony Whetton, are using a state-of-the-art mass-spectrometry based proteomics facility at the Paterson Institute of Cancer Research to identify proteins that control breast cancer stem cells. The facility - one of only a few in the UK - enables them to break up breast cancer stem cell proteins and analyse the sequence of amino acids to identify novel proteins that control the cells' growth.

Dr Clarke says: "Our work has revealed the importance of several pathways not previously known to regulate stem cell survival and self-renewal, which is tremendously exciting. Inhibitors of signalling pathways that regulate cancer stem cells could represent a new therapeutic modality in breast cancer, to be used in combination with current treatments in the near future."


'/>"/>

Contact: Mikaela Sitford
07-768-980-942
University of Manchester
Source:Eurekalert

Related medicine news :

1. Unique Smoking Helpline Launched In Manchester
2. Unique Smoking Helpline Launched In Manchester
3. Distinguished Scientist Award Conferred on Manchester Dentist
4. Researchers urge caution in using ear tube surgery
5. Researchers Scale to assess the Severity of Epilepsy in Kids
6. Researchers identify the early makers of Neonatal Sepsis
7. OHSU Researchers Announce New Discovery
8. Researchers Identify Gene Connected To Bipolar Disorder
9. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
10. Researchers trick Alzheimers Enzyme
11. Researchers find new HIV hiding place
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... (PRWEB) , ... June 26, 2017 , ... ... group in the country, today announced the hiring of Richard Robinson as chief ... diverse leadership and operations experience, with a proven track record of simplifying business ...
(Date:6/26/2017)... ... June 26, 2017 , ... If the devil is in ... red these days. According to recent estimates, 75 – 80% of the medical ... Some studies point to Electronic Health Records (EHR) with automated features designed to ...
(Date:6/25/2017)... ... June 24, 2017 , ... Create a feel-good lyric music video in Final Cut Pro X ... the timeline and write in the lyrics to any song. ProLyric flies in the text ... of the text can be added modularly for optimal control. ProLyric makes editing any music ...
(Date:6/25/2017)... ... ... currently bearing down on Northern California pushing temperatures to the maximum, many people are heading ... laser hair removal. , The process of summer waxing and constantly shaving unwanted hair, ... to do is get out, dive in and cool off. There is a way to ...
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. Mitchell Mehlman and his ... Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine and emergency dental care. ... fit into their patients’ busy lifestyles. Dental365 also gladly work with most insurance ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... , May 30, 2017 Hill-Rom Holdings, Inc. ... Annual Global Healthcare Conference on Tuesday, June 13, 2017, ... John Greisch , Hill-Rom,s president and chief executive officer, is ... The live audio webcast can be accessed at http://ir.hill-rom.com/events.cfm ... conclusion of the live event through September 13, 2017. ...
(Date:5/29/2017)... May 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... which enables the functional selection of stem cells, today ... the first quarter ended March 31 st , 2017. ... accomplishments in the first quarter of 2017," said Dr. ... we announced the treatment of the first blood cancer ...
(Date:5/26/2017)... SANTA BARBARA, Calif. , May 25, 2017 /PRNewswire-USNewswire/ ... the United States , Direct Relief is working ... of overdose-reversing Naloxone available at no cost to community ... and other nonprofit providers nationwide. "Pfizer ... expanding access to medicines and ensuring patient safety through ...
Breaking Medicine Technology: