Navigation Links
Mammography may increase breast cancer risk in some high-risk women
Date:12/1/2009

CHICAGO Low-dose radiation from annual mammography screening may increase breast cancer risk in women with genetic or familial predisposition to breast cancer, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

"For women at high risk for breast cancer, screening is very important, but a careful approach should be taken when considering mammography for screening young women, particularly under age 30," said Marijke C. Jansen-van der Weide, Ph.D., epidemiologist in the Department of Epidemiology and Radiology at University Medical Center Groningen in the Netherlands. "Further, repeated exposure to low-dose radiation should be avoided."

Women who are at high risk for breast cancer need to begin screening at a younger age, because they often develop cancer earlier than women at average risk. However, according to Dr. Jansen-van der Weide and colleagues, young women with familial or genetic predisposition to the disease may want to consider alternative screening methods to mammography, because the benefit of early tumor detection in this group of women may be offset by the potential risk of radiation-induced cancer.

According to the American Cancer Society, there is strong evidence supporting the benefits of mammography for women after age 40. However, there are conflicting reports regarding the benefits of mammography for women under 40. Alternative screening methods such as ultrasound and MRI may be made available to younger women, but are generally used as an adjunct to mammography.

The American Cancer Society recommends that some women at high risk (greater than 20 percent lifetime risk) should have MR imaging and mammography every year, typically beginning at age 30.

The researchers conducted an analysis of peer-reviewed, published medical research to determine if low-dose radiation exposure affects breast cancer risk among high-risk women. Out of 47 articles found on the topic, six were selected by the reviewers for inclusion in their analysis. Four studies looked at the effect of exposure to low-dose radiation among breast cancer gene mutation carriers, and two studies researched the effect of radiation on women with a family history of breast cancer. Using data from these studies, the researchers were able to calculate pooled odds ratios to estimate radiation-induced breast cancer risk.

The results showed that among all high-risk women in the study, average increased risk of breast cancer due to low-dose radiation exposure was 1.5 times greater than that of high-risk women not exposed to low-dose radiation. High-risk women exposed before age 20 or with five or more exposures were 2.5 times more likely to develop breast cancer than high-risk women not exposed to low-dose radiation.

"Our findings suggest that low-dose radiation increases breast cancer risk among these young high-risk women, and a careful approach is warranted," Dr. Jansen-van der Weide said.

She noted that this analysis is based on a small study sample and should be interpreted with caution. Dr. Jansen-van der Weide also pointed out that these results apply only to specific high-risk groups of women. Women at average risk were not assessed in this study.

In general, early detection with mammography and prompt treatment can significantly improve a woman's chances of survival. More than 90 percent of women whose breast cancer is found in an early stage will survive. For young, high-risk women and their doctors, it is important to weigh the benefits against any potential risk when making a decision about annual breast cancer screening with mammography.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Mammography May Increase Breast Cancer Risk in Some High-Risk Women
2. Guardian to Continue Following Its Current Coverage Guidelines for Mammography Screenings
3. USPSTF Mammography Recommendations Should Be Specifically Excluded From Health Care Reform Legislation
4. Statement by the Scientific Advisory Board of the Patient Advocate Foundation/National Patient Advocate Foundation on Changes to the USPSTF Mammography Guidelines
5. Breaking Through the Mammography Controversy
6. Task Force Member Defends Mammography Guidelines
7. Parascript Announces AccuDetect 3.0 Computer Aided Detection (CAD) Algorithms With Improved Performance for CAD Vendors and Manufacturers of Mammography Systems
8. Maurer Foundation for Breast Health Education Statement on USPSTF Guidelines for Mammography
9. Mammography: What to Do Now?
10. Lives Will Be Lost With Proposed Changes to Mammography Guidelines
11. USPSTF mammography recommendations will result in countless unnecessary breast cancer deaths each year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... ... February 28, 2017 , ... The role of females ... from military to civilian life. Body image dissatisfaction is largely unexamined among female ... and greater occurrence of chronic mental health conditions than female civilians. Female veterans ...
(Date:2/27/2017)... ... February 27, 2017 , ... Robert E. Burke, MD, PhD, had a ... impoverished upbringing and life experiences could have led him down a much different path. ... Tales of Parenting, Perseverance and Pediatrics,” Dr. Burke shares a personal account of the ...
(Date:2/27/2017)... ... February 27, 2017 , ... Orange County dentist, ... inflammatory gum condition that occurs when the bacteria in plaque infect the gums and ... as a scaling and root planing or SRP, and can include surgical therapies if ...
(Date:2/27/2017)... ... February 27, 2017 , ... ... alcohol treatment programs in British Columbia, Canada, at https://www.sunshinecoasthealthcentre.ca/ , is proud ... The new hire, Mackenzie Alsager, showcases the Centre's commitment to innovation in drug ...
(Date:2/26/2017)... ... 2017 , ... Today, A' Design Awards & Competition has ... Design Awards. , The 7th A' Social Design Award is open for ... with realized projects and conceptual works. , The first phase of the International ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... , Feb. 27, 2017 This report ... Teva and its partnering interests and activities since 2010. ... Description The Partnering Deals and Alliance since ... activity of one of the world,s leading life sciences ... upon purchase to ensure inclusion of the most up ...
(Date:2/27/2017)... The report "(CTMS)  Clinical Trial Management System Market ... Based), By Delivery Mode (Web, Cloud, On Premise), By End Use (Pharmaceutical ... Outlook (U.S., Canada , Germany , ... Russia , China , India ... , Taiwan , Brazil , ...
(Date:2/27/2017)... Feb. 27, 2017   Royal Philips ... global leader in health technology, today announced 510(k) ... (FDA) to market its ElastQ Imaging capability, further ... ultrasound systems. ElastQ Imaging enables simultaneous imaging of ... essential for the diagnosis of various liver conditions. ...
Breaking Medicine Technology: