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Mammographic density and risk of breast cancer
Date:4/21/2010

time of enrollment using the Breast Imaging-Reporting and Data System (BI-RADS) a quality assurance mammography tool designed to measure clinical density that, for breast composition categories, is classified as almost entirely fat, scattered density, heterogeneous density and extremely dense. The differences between the BI-RADS measures obtained from the two time periods were used to evaluate changes in density over time.

Results showed that cases were less likely to have experienced a reduction of one BI-RADS density category or more (37 percent vs. 38.6 percent) after their earliest mammogram.

"Women who experienced a reduction of at least one density category over the six years were at reduced risk of breast cancer (28 percent lower risk) compared to those whose density was unchanged," Vachon said. "And, women who increased by one or more BI-RADS categories over the time period had suggestion of increased risk."

5741. Change in mammographic density with estrogen and progestin therapy: A measure of breast cancer risk in the Women's Health Initiative
Embargo: 8:00 a.m. ET., April 21, 2010

Change in mammographic density may be a useful intermediate marker to explain the increased breast cancer risk among postmenopausal women using estrogen and progestin therapy (EPT), according to results of a case-control study conducted within the Women's Health Initiative (WHI) randomized trial of EPT.

Mammographic density is one of the strongest predictors of breast cancer risk.

"As breast density increases so does women's risk for breast cancer we were able to predict this risk in our study population," said lead researcher Celia Byrne, Ph.D., assistant professor of oncology at the Lombardi Comprehensive Cancer Center at Georgetown University.

Using data from the WHI, Byrne and colleagues evaluated the baseline and one-year follow-up mammograms from 97 women who developed invasive breast cance
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Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

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