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Mammographic density and risk of breast cancer
Date:4/21/2010

n trials to help us decide which interesting strategies should be carried further into very large Phase III studies with cancer incidence as an endpoint."

The AACR has highlighted the following abstracts on new research in mammographic density, which will be presented at the Annual Meeting:

4828. Longitudinal breast density and risk of breast cancer
Embargo: 3:55 p.m. ET., April 20, 2010

Women who have a decrease in breast density over a six-year period may have a decreased risk of developing breast cancer compared with women whose breast density remained stable.

"A decrease in breast density appears to be associated with a lower breast cancer risk, and importantly, this result takes into account baseline breast density, as well as changes in BMI that occurred between mammographic assessments," said lead researcher Celine M. Vachon, Ph.D., associate professor of epidemiology in the College of Medicine at the Mayo Clinic, Rochester, Minn.

Vachon and colleagues evaluated whether changes in breast density over time are associated with breast cancer risk using data collected as part of the Mayo Mammography Health Study, which included 19,924 women who had a mammogram at the Mayo Clinic between 2003 and 2006. Participants had never had breast cancer and were more than 35 years old at time of the mammogram.

Study variables were derived from clinical databases as well as self-administered questionnaires completed by the participants. The researchers performed linkages to Mayo and state cancer registries to identify new breast cancer events.

To examine the association between change in density with breast cancer, longitudinal analyses were conducted on the 219 breast cancer cases and 1,900 cancer-free cases that represented a random sample of the entire cohort.

Breast density was obtained from the earliest available historical mammogram, and from the mammogram that was obtained at the
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Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

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