Navigation Links
Mammogram sensitivity depends on menstrual cycle
Date:12/6/2010

SEATTLETry to schedule your screening mammogram during the first week of your menstrual cycle. It might make breast cancer screening more accurate for pre-menopausal women who choose to have regular mammograms. This recommendation comes from an article published online December 3 in Radiology by Diana Miglioretti, PhD, a senior investigator at Group Health Research Institute.

Dr. Miglioretti and her co-authors are working on an issue at the heart of recent controversies about breast cancer screening mammograms. In November 2009, new recommendationsincluding that women should discuss with their doctors whether to begin having regular screening mammograms at age 40 or wait till age 50were issued by the U.S. Preventive Services Task Force, an independent panel of health care providers who generate medical guidelines based on clinical research.

Some facts related to the new recommendations prompted the study by Dr. Miglioretti and colleagues:

  • Mammography can detect cancer in women in their 40s.
  • But these women are at higher risk than are older women for a false-negative result (missing a cancer that is present) or a false-positive result (recalling a woman for further workup when cancer is not present).
  • False positives lead to unnecessary tests, including biopsies.
  • Women in their 40s tend to have dense breast tissue, making their mammograms hard to interpret. Dense breast tissue shows up as white on a mammogram and can obscure abnormal findings, which are also white.
  • Breast density varies slightly with menstrual cycle.

Dr. Miglioretti's team asked whether mammography conducted at different times in the menstrual cycle, when breast density may be different, is more sensitive for finding breast cancers or more specific for ruling out cancer. They examined 387,218 screening mammograms from premenopausal women. Of these, 1,283 were linked to an actual case of breast cancer. The data were from the Breast Cancer Surveillance Consortium, a network of research sites nationwideincluding Group Health Research Institute, which has collected breast cancer screening data since 1994.

"Premenopausal women having regular screening mammography could benefit from scheduling their exams during the first week of their menstrual cycle," says Miglioretti. She and her collaborators found that in the first week, when breast tissue may be less dense and not engorged, mammography was more sensitive at detecting cancer. Specificity, which is the ability to reliably recognize the absence of breast cancer, did not change with menstrual cycle.

Miglioretti notes, however, that the increased sensitivity was only for women with a screen in the past two years, who were assumed to be having regular screens, and not for women being screened for the first time. Miglioretti says this result was "surprising," but offers some possible reasons. In general, when first screens find a tumor, it's relatively large. Low breast density is more important for detecting small tumors, so the menstrual cycle influence might not have been seen for first screens. "Larger tumors may be easier to see later in the menstrual cycle, but this needs to be studied," says Miglioretti. In addition, her findings do not apply to diagnostic mammography: mammography performed to work up a symptom such as a breast lump. If a woman finds a breast lump or has another breast concern, she should contact her doctor right away.

Dr. Miglioretti and her co-authors know that women can't always predict their cycle, but say if they can, scheduling during the first week may have an additional advantage. Many women experience breast tenderness in the second half of their cycle, so avoiding this time could reduce mammography discomfort.

Current recommendations are that women aged 50-74 have a routine screening mammogram every other year. Women are encouraged to consult with their health care providers to find a mammography schedule that fits their family history and personal preferences.


'/>"/>

Contact: Joan DeClaire
declaire.j@ghc.org
206-947-4560
Group Health Research Institute
Source:Eurekalert

Related medicine news :

1. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
2. Survey Finds Access to Mammograms Declining for Women Under Age 50
3. The American Association on Health and Disability (AAHD) and the Susan G. Komen for the Cure Partner to Increase Accessibility for Women with Disabilities at Mammogram Facilities in the DC Metro Area
4. Access to Mammograms Drops After Guidelines Change
5. Mammogram Plus MRI Seems Cost-Effective in High-Risk Women
6. Mammogram Plus MRI Cost-Effective in High-Risk Women
7. 89 Women Celebrate Mardi Gras with Mammograms
8. Mammograms May Not Boost Survival, Danish Study Suggests
9. Physicians who interpret mammograms may benefit from additional training
10. For Younger Women, Mammograms Not Too Effective: Study
11. Screening mammograms in younger women have low accuracy and detect few cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... Judy Buchanan, co-owner ... in Frederick, MD. Judy says, “I am passionate about sharing Reiki as a ... very difficult and challenging time.” , A Certified Medical Reiki™ Master trained by ...
(Date:3/24/2017)... ... ... “Vintage and Harvest A Cultivation of Christian Love” is the creation of published author, ... his wife, Anna Marie. He and his wife are the proud parents of four ... of “Shadow and Substance.” , “Love, the agape kind, is seen as more than ...
(Date:3/23/2017)... & Seattle, WA (PRWEB) , ... March 23, 2017 , ... ... health emergency and now estimates that there could be four million Zika-related cases in ... epidemics to date with numbers of US cases reported per year skyrocketing to an ...
(Date:3/23/2017)... Alexandria, Virginia (PRWEB) , ... March 23, 2017 ... ... quality public health services to their communities, 16 more public health departments have ... This week’s decisions bring another 4.5 million people into the expanding network of ...
(Date:3/23/2017)... ... 2017 , ... The IoT (Internet of Things) is revolutionizing the way the ... on businesses and individual consumers alike. Laboratories can maximize their profit margin by ... from $4 trillion to $11 trillion dollars by the year 2025. McKinsey expects the ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017 Abdominal Aortic Aneurysm Repair Devices ... by 2022, Globally, registering a CAGR of 5.1% from 2016 to 2022. The endovascular ... to dominate the market during the study period. Continue ... ... ...
(Date:3/24/2017)... Mar. 24, 2017 Research and Markets ... the U.S.: Consumer Strategies" report to their offering. ... Pain ... approach and treat their physical pain, emphasizing consumer survey analysis, ... pain sufferers and adults who have selected illnesses/conditions strongly associated ...
(Date:3/24/2017)... FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to gain popularity. A ... market will reach a value of USD 55.8 billion by 2025. ... growing industry. By the end of 2016, 28 states have now laws ... conservative states like Arkansas and North ...
Breaking Medicine Technology: