Navigation Links
Malignant brain tumors: Benefit of PET and PET/CT in the detection of recurrences is not assessable

This release is available in German.

Malignant gliomas are fast-growing brain tumours with poor prospects of recovery depending on disease stage. Experts hope that the examination of patients by means of positron emission tomography (PET) is more helpful in the choice of the right treatment than other procedures. In a final report the German Institute for Quality and Efficiency in Health Care (IQWiG) has now investigated the benefit of PET in the detection of recurrences. According to this report, no robust conclusions are possible on the advantages or disadvantages of PET.

Two research questions investigated

The Institute investigated two research questions:

First question: Does PET as a single device or as a combination of PET and computer tomography (CT) in one device (PET/CT) contribute to patients with recurrence of glioma surviving longer or experiencing fewer complications caused by their disease or treatment? This question could not be answered by IQWiG, as no robust study was found in the literature allowing any conclusions on the patient-relevant (additional) benefit of this intervention.

The Institute also investigated a second question: Can recurrence of glioma after treatment be detected more accurately with PET or PET/CT than with other methods? Twelve studies on PET conducted over a period of two decades were identified; however, the results for this procedure differed so substantially between studies that no general answer could be provided. Not a single study on PET/CT was found.

This lack of good studies is regrettable. PET has been applied in studies investigating patients with brain tumours since the early eighties; there would have been enough time to conduct meaningful studies. IQWiG therefore advocates that these missing studies be conducted as quickly as possible. As gliomas are relatively rare, ideally several hospitals should cooperate on an international level in order to obtain robust data within a reasonable period of time.

How does PET work?

CT and magnetic resonance imaging (MRI), also referred to as magnet resonance tomography (MRT), are procedures used to diagnose brain tumours. These devices can depict whole organs in a three-dimensional manner. If a patient with a brain tumour is treated with radiotherapy, it is often not possible to distinguish on images of the brain whether the visible residuals represent active cancer tissue or tissue residuals destroyed by radiation (radiation necroses).

PET is supposed to help solve this problem. For this purpose, patients are injected a contrast agent that emits weak and non-toxic radiation. As tumour tissue often has a more active metabolism than healthy or necrotic tissue, the radioactive contrast agent accumulates there. This "illuminating" tissue in the body can be measured by means of PET and blended into CT images, so that doctors can see the location and metabolic activity of any tissue abnormalities at the same time. In newer studies, PET and MRI are also combined.

Even if the PET examination provided more information, this would not necessarily mean that patients would benefit from it. The decisive question is whether PET or PET/CT improves the treatment of patients by, for example, helping doctors choose the best treatment for the individual patient.


Contact: Anna-Sabine Ernst
Institute for Quality and Efficiency in Health Care

Related medicine news :

1. Novel RNA interference screening technique identifies possible path for malignant glioma treatment
2. Huge pelvi-abdominal malignant inflammatory myofibroblastic tumor
3. Gadgets not related to teenagers brain pain
4. Dementia Rates Escalate as Brain Capacity Diminishes with Age
5. Researchers discover new way to kill pediatric brain tumors
6. Scientists Pinpoint Area of Brain That Fears Losing Money
7. Physical Changes in Brain Linked to Altered Spirituality
8. Pro Athletes Brains React at Olympic Speed
9. Neuroscientists reveal new links that regulate brain electrical activity
10. Brain Scan Shows What Beauty is Worth
11. Study supports alternative anti-seizure medication following acute brain injury
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... The Multiple System Atrophy Coalition has announced the ... System Atrophy (MSA) research, timed today to coincide with Giving Tuesday 2015, a global ... their ability to work and be productive, to do simple daily activities like walking ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... in rural West Tennessee to receive Gigabit Internet through a partnership this year ... America’s largest cities, Henderson is an attractive destination for entrepreneurs who want to ...
(Date:12/1/2015)... ... December 01, 2015 , ... Integrated Rental Services (“Integrated ... Industries International, LLC (“JII”). , With support from JII, Integrated Rental is poised ... hospitals, surgery centers, clinics, research labs and medical facilities across the United States. ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... and hematology continuing medical education (CME), today announced that the first annual School ... New York. , “The prevention, detection and treatment of gastrointestinal cancers are undergoing ...
(Date:12/1/2015)... ... December 01, 2015 , ... Dr. Paul Vitenas, one of the ... been named by MedEsthetics magazine as the Best Single Physician Practice in the nation. ... many elite aesthetic physicians honored by the industry publication. , Dr. Vitenas said ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... VANCOUVER , Dec. 1, 2015  Following an ... (NASDAQ: OGXI ) announced today that its Phase ... interim futility analysis of the intent-to-treat (ITT) population. In ... identified by the DMC. Both the DMC and OncoGenex ... expected in the second half of 2016, depending on ...
(Date:12/1/2015)... , Dec. 1, 2015 WellStar Health ... Dallas, Texas -based Tenet Healthcare,s five metro ... of Trustees approved the strategic move following the conclusion ... its proven clinical care models and patient safety programs ... to healthcare to new communities. --> ...
(Date:12/1/2015)... , Dec. 1, 2015   Nottingham Spirk ... today announced the publication of a free ... Direct-to-Consumer Medical Market". The whitepaper gives medical product ... successfully penetrating this lucrative segment. Nottingham ... products to manage their own health, save money ...
Breaking Medicine Technology: