Navigation Links
Male mice exposed to chronic social stress have anxious female offspring

BOSTON (August 22, 2012) A study in mice conducted by researchers at Tufts University School of Medicine (TUSM) suggests that a woman's risk of anxiety and dysfunctional social behavior may depend on the experiences of her parents, particularly fathers, when they were young. The study, published online in Biological Psychiatry, suggests that stress caused by chronic social instability during youth contributes to epigenetic changes in sperm cells that can lead to psychiatric disorders in female offspring across multiple generations.

"The long-term effects of stress can be pernicious. We first found that adolescent mice exposed to chronic social instability, where the cage composition of mice is constantly changing, exhibited anxious behavior and poor social interactions through adulthood. These changes were especially prominent in female mice," said first author Lorena Saavedra-Rodrguez, Ph.D., postdoctoral fellow in the Larry Feig laboratory at Tufts University School of Medicine (TUSM).

The researchers then studied the offspring of these previously-stressed mice and observed that again female, but not male, offspring exhibited elevated anxiety and poor social interactions. Notably, even though the stressed males did not express any of these altered behaviors, they passed on these behaviors to their female offspring after being mated to non-stressed females. Moreover, the male offspring passed on these behaviors to yet another generation of female offspring.

"We are presently searching for biochemical changes in the sperm of stressed fathers that could account for this newly appreciated form of inheritance" said senior author Larry A. Feig, Ph.D., professor of biochemistry at Tufts University School of Medicine and member of the biochemistry and neuroscience program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts University. "Hopefully, this work will stimulate efforts to determine whether similar phenomena occur in humans."

Contact: Siobhan Gallagher
Tufts University, Health Sciences Campus

Related medicine news :

1. U.S. Children Exposed to Hours of Background TV Daily
2. Women Exposed to Violence Might Have More Risky Sex
3. Study says children exposed to tobacco smoke face long-term respiratory problems
4. Children exposed to HIV in the womb at increased risk for hearing loss
5. No difference in death rates among patients exposed to common rheumatoid arthritis drugs
6. Chronicling pink slimes fall from grace
7. Adjusting Your Attitude About Chronic Pain May Help You Sleep
8. Chronic cocaine use triggers changes in brains neuron structure
9. Chronic Heartburn May Boost Risk for Esophageal Cancer
10. Should oxygen be used for patients with chronic heart failure?
11. Researchers identify a life-and-death molecule on chronic leukemia cells
Post Your Comments:
(Date:11/29/2015)... ... November 30, 2015 , ... Gift ... company, Sublime Beauty NATURALS®. All products are available on Amazon or its webstore. ... organic facial serums and USDA Certified Organic Sesame Oil for Oil Pulling," says ...
(Date:11/29/2015)... ... 2015 , ... NewsWatch featured X-wing as part of its monthly Tech Report, ... technology expert and special reporter for NewsWatch, conducted the review and shared with viewers ... the future because flying cars are about to become a reality. Where’s the idea ...
(Date:11/29/2015)... ... November 29, 2015 , ... ProStatic Analog Distortion from ... designed specially for Final Cut Pro X. FCPX users can now ... modification controls. Destoying and creating chaotic distortion is now quick and simple, putting ...
(Date:11/28/2015)... (PRWEB) , ... November 28, 2015 , ... Safe storage ... creativity of two inventors, one from Lakewood, New Jersey and the other from Bradley ... the patent-pending PROTECTOR to save the expense of having to replace NuvaRings more often ...
(Date:11/27/2015)... ... November 28, 2015 , ... There is only one major question facing all ... year? , This question has not been an easy question to answer. Especially when ... and the younger workforce don’t share the same discipline around working long hours. ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... -- The GE Health Cloud 1 was unveiled today at ... North America (RSNA) meeting in Chicago ... cloud ecosystem and its applications will connect radiologists and clinicians ... teams – both inside and outside the hospital setting. ... "As the digital industrial leader, we are betting big on ...
(Date:11/27/2015)... Une nouvelle approche consistant ... contre le cancer avancé.    --> ... au traitement photodynamique au Bremachlorin contre le cancer ... nouvelle approche consistant à combiner l,immunothérapie au traitement ...    Clinical Cancer Research . ...
(Date:11/27/2015)... , Nov. 27, 2015  Lannett Company, ... it has completed the acquisition of Kremers Urban ... subsidiary of global biopharmaceuticals company UCB S.A. (Euronext: ... Lannett has acquired KU from UCB for ... certain adjustments, including a customary working capital adjustment, ...
Breaking Medicine Technology: