Navigation Links
Male kidneys for men only?
Date:7/9/2008

The gender of donor and recipient plays a larger role in kidney transplants than previously assumed. Female donor kidneys do not function as well in men due to their smaller size. Women have a higher risk of rejecting a male donor kidney. Therefore, in the future, gender should be considered more in the allocation of donor kidneys, say researchers from Basel and Heidelberg.

These results are based on an analysis of the "Collaborative Transplant Study", the world's largest database with long-term results of organ transplants under the leadership of Professor Dr. Gerhard Opelz, Medical Director of the Department of Transplantation Immunology at the Institute of Immunology of Heidelberg University Hospital. Researchers Professor Dr. Alois Gratwohl, Basel University Hospital, and Professor Opelz published their analysis in the medical journal The Lancet (Vol. 372, p. 49).

Data from almost 200,000 kidney recipients analyzed

The researchers analyzed data from almost 200,000 organ recipients who received a kidney transplant between 1985 and 2004. Overall, transplanting a female kidney was less successful than a male kidney. This is attributed to the fact that due to their smaller size, female kidneys have fewer nephrons the active components of the kidneys that filter urine.

Immunological rejection problems occurred most frequently when women received a male kidney for them, the risk that the organ would be rejected was eleven percent higher in the first year after the operation than for other donor-recipient combinations. And even two to ten years after the operation, the risk of rejection was still 10 percent higher than for other groups.

Y chromosome likely responsible for rejection

"The higher rate of rejection is most likely caused by the gender-specific Y chromosome in men," explains Professor Opelz. In the future, gender should be one of the factors considered when making a decision on assigning an organ to a patient.

However, the higher risk of rejection in women is partially compensated by the effect of more nephrons in a male kidney, so that on average, female recipients of male kidneys do not have significantly poorer overall results.

Should kidneys be allocated based on gender in the future?

The allocation of organs for German patients is organized in coordination with five other European states by the computer of the organ distribution center Eurotransplant. Donor kidneys are assigned according to criteria (waiting time, compatibility, etc.) set by the commission for organ transplants of the German Medical Association. The computer program was also developed by the immunologists from Heidelberg.

Immune functions associated with the Y chromosome and which can lead to rejection of the organ need to be studied more closely in the future, emphasizes Connie L. Davis, kidney expert at the University of Washington in Seattle (USA) in an editorial in The Lancet. However, a recommendation to transplant only same-sex organs is not yet appropriate, because long-term success is good even if the donor and recipient are of the opposite sex, says Davis.


'/>"/>

Contact: Dr. Annette Tuffs
annette.tuffs@med.uni-heidelberg.de
49-622-156-4536
University Hospital Heidelberg
Source:Eurekalert

Related medicine news :

1. Low Lead Exposures Can Hurt Kidneys
2. Higher-risk kidneys may help solve organ shortage facing older adults
3. Study: Before a CT scan or angiogram, many people should take inexpensive drug to protect kidneys
4. Doctors See How Cancer Drug Can Damage Kidneys
5. Whats wrong with selling kidneys?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... York, New York (PRWEB) , ... January 24, 2017 , ... ... for Brazilian butt lifts is on the rise. According to the American Society ... augmentations since 2000. On average, these procedures are performed every 30 minutes of every ...
(Date:1/24/2017)... PA (PRWEB) , ... January 24, 2017 , ... ... showcase its newest technology offering, Processing Assurance Control Equipment (PACE), at the International ... 2, 2017. , PeroxyChem’s booth will highlight the new technology that is used ...
(Date:1/24/2017)... ... January 24, 2017 , ... Twelve startups have been ... 2017 Cupid's Cup Entrepreneurship Competition. Chaired by Under Armour Founder and CEO Kevin ... will showcase their businesses on February 6, 2017, at Under Armour’s global headquarters ...
(Date:1/24/2017)... ... January 24, 2017 , ... Bellus Medical, a leader in medical aesthetics, today ... his new role Dr. Dobke will provide physician oversight for in-house clinical studies and ... of Plastic Surgery and Associate Professor of Surgery at UC San Diego Health and ...
(Date:1/24/2017)... ... January 24, 2017 , ... Inspiration, ... , Well-meaning studies such as the Fordham Institute’s High Stakes for High ... students, such as including gifted or high-achieving students as a subgroup and reporting ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)...  In a major study released this weekend ... 1 ( http://www.multivu.com/players/English/7899551-nephrocheck-test-acute-kidney-injury-outcomes/ ), Astute ... identified patients at high risk of Acute Kidney ... randomized control trial led by Alexander Zarbock ... institution,s standard of care or a treatment per ...
(Date:1/24/2017)... Jan. 24, 2017 Data4Cure, Inc. today announced ... its Biomedical Intelligence® Cloud - a semantic data-driven discovery ... of genomic, molecular and clinical data that are accumulating ... a session hosted by Data4Cure at the Precision Medicine ... The company,s Biomedical Intelligence® Cloud ...
(Date:1/24/2017)... , Jan. 24, 2017 Regeneron Pharmaceuticals, Inc. ... Public today recognized 40 finalists in the Regeneron Science ... and math competition for high school seniors. Finalists were ... of their research projects. The finalists will ... from March 9-15 to undergo a rigorous judging process ...
Breaking Medicine Technology: