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Male kidneys for men only?
Date:7/9/2008

The gender of donor and recipient plays a larger role in kidney transplants than previously assumed. Female donor kidneys do not function as well in men due to their smaller size. Women have a higher risk of rejecting a male donor kidney. Therefore, in the future, gender should be considered more in the allocation of donor kidneys, say researchers from Basel and Heidelberg.

These results are based on an analysis of the "Collaborative Transplant Study", the world's largest database with long-term results of organ transplants under the leadership of Professor Dr. Gerhard Opelz, Medical Director of the Department of Transplantation Immunology at the Institute of Immunology of Heidelberg University Hospital. Researchers Professor Dr. Alois Gratwohl, Basel University Hospital, and Professor Opelz published their analysis in the medical journal The Lancet (Vol. 372, p. 49).

Data from almost 200,000 kidney recipients analyzed

The researchers analyzed data from almost 200,000 organ recipients who received a kidney transplant between 1985 and 2004. Overall, transplanting a female kidney was less successful than a male kidney. This is attributed to the fact that due to their smaller size, female kidneys have fewer nephrons the active components of the kidneys that filter urine.

Immunological rejection problems occurred most frequently when women received a male kidney for them, the risk that the organ would be rejected was eleven percent higher in the first year after the operation than for other donor-recipient combinations. And even two to ten years after the operation, the risk of rejection was still 10 percent higher than for other groups.

Y chromosome likely responsible for rejection

"The higher rate of rejection is most likely caused by the gender-specific Y chromosome in men," explains Professor Opelz. In the future, gender should be one of the factors considered when making a decision
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Contact: Dr. Annette Tuffs
annette.tuffs@med.uni-heidelberg.de
49-622-156-4536
University Hospital Heidelberg
Source:Eurekalert

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