Navigation Links
Male kidneys for men only?
Date:7/9/2008

The gender of donor and recipient plays a larger role in kidney transplants than previously assumed. Female donor kidneys do not function as well in men due to their smaller size. Women have a higher risk of rejecting a male donor kidney. Therefore, in the future, gender should be considered more in the allocation of donor kidneys, say researchers from Basel and Heidelberg.

These results are based on an analysis of the "Collaborative Transplant Study", the world's largest database with long-term results of organ transplants under the leadership of Professor Dr. Gerhard Opelz, Medical Director of the Department of Transplantation Immunology at the Institute of Immunology of Heidelberg University Hospital. Researchers Professor Dr. Alois Gratwohl, Basel University Hospital, and Professor Opelz published their analysis in the medical journal The Lancet (Vol. 372, p. 49).

Data from almost 200,000 kidney recipients analyzed

The researchers analyzed data from almost 200,000 organ recipients who received a kidney transplant between 1985 and 2004. Overall, transplanting a female kidney was less successful than a male kidney. This is attributed to the fact that due to their smaller size, female kidneys have fewer nephrons the active components of the kidneys that filter urine.

Immunological rejection problems occurred most frequently when women received a male kidney for them, the risk that the organ would be rejected was eleven percent higher in the first year after the operation than for other donor-recipient combinations. And even two to ten years after the operation, the risk of rejection was still 10 percent higher than for other groups.

Y chromosome likely responsible for rejection

"The higher rate of rejection is most likely caused by the gender-specific Y chromosome in men," explains Professor Opelz. In the future, gender should be one of the factors considered when making a decision on assigning an organ to a patient.

However, the higher risk of rejection in women is partially compensated by the effect of more nephrons in a male kidney, so that on average, female recipients of male kidneys do not have significantly poorer overall results.

Should kidneys be allocated based on gender in the future?

The allocation of organs for German patients is organized in coordination with five other European states by the computer of the organ distribution center Eurotransplant. Donor kidneys are assigned according to criteria (waiting time, compatibility, etc.) set by the commission for organ transplants of the German Medical Association. The computer program was also developed by the immunologists from Heidelberg.

Immune functions associated with the Y chromosome and which can lead to rejection of the organ need to be studied more closely in the future, emphasizes Connie L. Davis, kidney expert at the University of Washington in Seattle (USA) in an editorial in The Lancet. However, a recommendation to transplant only same-sex organs is not yet appropriate, because long-term success is good even if the donor and recipient are of the opposite sex, says Davis.


'/>"/>

Contact: Dr. Annette Tuffs
annette.tuffs@med.uni-heidelberg.de
49-622-156-4536
University Hospital Heidelberg
Source:Eurekalert

Related medicine news :

1. Low Lead Exposures Can Hurt Kidneys
2. Higher-risk kidneys may help solve organ shortage facing older adults
3. Study: Before a CT scan or angiogram, many people should take inexpensive drug to protect kidneys
4. Doctors See How Cancer Drug Can Damage Kidneys
5. Whats wrong with selling kidneys?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... City, California (PRWEB) , ... February 10, 2016 ... ... Imaging Society (WMIS), known as the World Molecular Imaging Congress (WMIC), will be ... theme for the 2016 meeting is “Imaging Biology…Improving Therapy.” The congress will highlight ...
(Date:2/10/2016)... , ... February 10, 2016 , ... LaserShip, a regional ... to the Food Bank of Eastern Michigan last Friday in order to aid in ... into the Midwest to include a facility located in Clio, only 15 miles away ...
(Date:2/10/2016)... Fort Walton Beach, Florida (PRWEB) , ... February ... ... that the innovative weather-forecasting company is unveiling its revolutionary new 2.0 version at ... new platform, MetLoop has “put the power of the world's most advanced weather ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... American Academy of Emergency Medicine , an emergency medicine professional association, ... practice management services . , The American Academy of Emergency Medicine, or AAEM, ...
(Date:2/10/2016)... ... 10, 2016 , ... Emergency rooms provide emergency care to stabilize critical health ... patients with dental emergencies at risk of losing a tooth or their smiles. Dr. ... , Common dental emergencies include:, , Avulsed or knocked-out teeth ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... PRINCETON, New Jersey and OR AKIVA, ... Regentis Biomaterials Ltd., a leader ... of its Series D investment round on February 5, ... Haisco Pharmaceutical Group ("Haisco"), a leading Chinese pharmaceutical ... Medica Partners, SCP Vitalife Partners, Generali Financial Holdings and ...
(Date:2/10/2016)... SAN DIEGO , Feb. 10, 2016 ALSP, ... Hack , MD as Consultant for Medical Affairs in preparation ... Michael Pierschbacher , PhD, CEO, stated, "We are ... team. We look forward to working with an individual of ... (TBI). We look forward to drawing deeply on his broad ...
(Date:2/10/2016)... , February 10, 2016 ... market research report "Pharmaceutical Packaging Equipment Market by Package ... & Serialization), by Product Type (Tablet, Powder, Cream, Syrup, ... by MarketsandMarkets, studies the global market during the forecast period ... grow at a CAGR of 6.9% during the forecast ...
Breaking Medicine Technology: